Cyclopentylpyrazoles as N-type calcium channel blockers

ABSTRACT

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: 
                         
wherein R 1 , R 2 , R 3 , Q, and G are defined herein.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims priority of the benefits of the filing of U.S.Provisional Application Ser. No. 61/683,775, filed Aug. 16, 2012. Thecomplete disclosures of the aforementioned related U.S. patentapplication is/are hereby incorporated herein by reference for allpurposes.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

The research and development of the invention described below was notfederally sponsored.

BACKGROUND OF THE INVENTION

Calcium ions play a fundamental role in the physiology and biochemistryof organisms and of cells. The entry of calcium into cells through ionchannels mediates a variety of cellular and physiological responses,including gene expression, signal transduction, neurotransmitterrelease, muscle contraction and hormone secretion. Ion channels areclassified by gating, or what opens and closes the channel to the fluxof ions. Voltage-gated ion channels open or close depending on thevoltage gradient across the plasma membrane, whereas ligand-gated ionchannels open or close depending on the binding of ligands to thechannel. The classification of voltage-gated calcium channels dividesthem into three groups: (i) high voltage-activated channels, whichinclude L-, N-, P- and Q-type channels; (ii) intermediatevoltage-activated R-type channels; and (iii) low voltage-activatedT-type channels.

The N-type calcium channel is distributed mainly in central andperipheral neurons, being localized primarily to presynaptic nerveterminals. This channel regulates the calcium flux required fordepolarization-evoked release of neurotransmitters from synapticendings. The transmission of pain signals from the periphery to thecentral nervous system (CNS) is mediated, inter alia, by N-type calciumchannels located in the spinal cord. Inhibition of the N-type calciumchannel in the superficial dorsal horn leads to a decrease in membraneexcitability and neurotransmitter release, resulting in pain relief. Inaddition, knock-out mice lacking the N-type calcium channel exhibitreduced nociceptive behaviors in animal models of pain.

N-type calcium channels have been shown to mediate the development andmaintenance of the neuronal sensitization processes associated withneuropathic pain and therefore provide attractive targets for thedevelopment of analgesic drugs. Three N-type calcium channel modulatorsare currently approved for the treatment of pain: ω-conotoxin MVIIA(ziconotide), marketed as Prialt®, potently and selectively blocks theN-type calcium channel and is indicated for the management of severechronic pain; gabapentin, marketed as Neurontin®, and pregabalin,marketed as Lyrica®, bind with high affinity to the α2δ subunit of theN-type calcium channel and are indicated for the treatment offibromyalgia, diabetic nerve pain and/or post-herpetic neuralgia pain.

It is an object of the present invention to provide N-Type calciumchannel blockers. It is also an object of the invention to provide amethod of treating, ameliorating or preventing pain by theadministration of a compound of Formula (I). And, it is an object of theinvention to provide a pharmaceutical composition comprising a compoundof Formula (I), useful for treating, ameliorating or preventing pain.

SUMMARY OF THE INVENTION

The present invention is directed to a compound of Formula (I)

wherein

R¹ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,trifluoromethoxy, and trifluoromethyl;

R² is hydrogen; or, R² may be taken with R¹ and the phenyl ring to whichR¹ and R² are both attached to form 2,3-dihydrobenzofuran-7-yl;

R³ is hydrogen, chloro, or fluoro;

Q is selected from the group consisting of Q1, Q2, and Q3;

wherein

R⁴ is selected from the group consisting of hydrogen, C₁₋₄alkyl,C₁₋₄alkoxy, cyano, fluoro, chloro, hydroxy, di(C₁₋₄alkyl)amino,(C₁₋₄alkyl)amino, amino, C₁₋₄alkylcarbonyl, and C₁₋₄alkylsulfonyl;

R⁵ and R⁶ are each independently selected from the group consisting ofhydrogen, C₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino;

G is selected from the group consisting of C₁₋₆alkyl,hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, hydroxy, allyl, 2-methylprop-1-enyl,cyano, oxime, phenoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl,4,4-dimethyl-cyclohexyl, C₃₋₆cycloalkyl(C₁₋₄alkyl, C₃₋₆cycloalkyloxy,C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl,pyrrolidin-1-yl, pyridinyloxy, trimethylsilyloxy, oxo,(tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 6-(morpholin-4-yl)-pyrimidin-3-yl,4-methyl-piperidin-1-yl, (1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-ylcarbonyloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl,

pyridin-3-yl optionally substituted with one to two substituents eachindependently selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, chloro, cyclopropyl, morpholin-4-yl, and C₁₋₄alkoxycarbonyl;

1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, 2-hydroxypropan-2-yl, methoxymethyl, C₃₋₆cycloalkyl,C₁₋₄alkoxycarbonyl, C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl;

1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents;

and

a spirofused heterocyclyl independently selected from the groupconsisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;

provided that a compound of Formula (I) is other than

-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;    or-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];    and enantiomers, diastereomers, solvates and pharmaceutically    acceptable salts thereof.

The present invention also provides, inter alia, a pharmaceuticalcomposition comprising, consisting of and/or consisting essentially of apharmaceutically acceptable carrier, a pharmaceutically acceptableexcipient, and/or a pharmaceutically acceptable diluent, and a compoundof Formula (I), or a pharmaceutically acceptable salt form thereof.

Also provided are processes for making a pharmaceutical compositioncomprising, consisting of, and/or consisting essentially of admixing acompound of Formula (I) and a pharmaceutically acceptable carrier, apharmaceutically acceptable excipient, and/or a pharmaceuticallyacceptable diluent.

The present invention further provides, inter alia, methods for treatingor ameliorating a N-Type calcium channel-modulated disorder in asubject, including a human or other mammal in which the disease,syndrome, or condition is affected by the modulation of the N-Typecalcium channel, such as pain and the diseases that lead to such pain,using a compound of Formula (I).

The present invention also provides, inter alia, methods for producingthe instant compounds and pharmaceutical compositions and medicamentsthereof.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the antihyperalgesic effect of Compound 71 in a rat CFAradiant heat model of inflammatory pain.

DETAILED DESCRIPTION OF THE INVENTION

With reference to substituents, the term “independently” refers to thesituation where when more than one substituent is possible, thesubstituents may be the same or different from each other.

The term “alkyl” whether used alone or as part of a substituent group,refers to straight and branched carbon chains having 1 to 8 carbonatoms. Therefore, designated numbers of carbon atoms (e.g. C₁₋₈) referindependently to the number of carbon atoms in an alkyl moiety or to thealkyl portion of a larger alkyl-containing substituent. In substituentgroups with multiple alkyl groups such as (C₁₋₆alkyl)₂-amino-, theC₁₋₆alkyl groups of the dialkylamino may be the same or different.

The term “alkoxy” refers to an —O-alkyl group, wherein the term “alkyl”is as defined above.

The terms “alkenyl” and “alkynyl” refer to straight and branched carbonchains having 2 or more carbon atoms, wherein an alkenyl chain containsat least one double bond and an alkynyl chain contains at least onetriple bond.

The term “cycloalkyl” refers to saturated or partially saturated,monocyclic or polycyclic hydrocarbon rings of 3 to 14 carbon atoms.Examples of such rings include cyclopropyl, cyclobutyl, cyclopentyl,cyclohexyl, cycloheptyl and adamantyl.

The term “benzo-fused cycloalkyl” refers to a 5- to 8-memberedmonocyclic cycloalkyl ring fused to a benzene ring. The carbon atom ringmembers that form the cycloalkyl ring may be fully saturated orpartially saturated.

The term “heterocyclyl” refers to a nonaromatic monocyclic or bicyclicring system having 3 to 10 ring members and which contains carbon atomsand from 1 to 4 heteroatoms independently selected from the groupconsisting of N, O, and S. Included within the term heterocyclyl is anonaromatic cyclic ring of 5 to 7 members in which 1 to 2 members arenitrogen, or a nonaromatic cyclic ring of 5 to 7 members in which 0, 1or 2 members are nitrogen and up to 2 members are oxygen or sulfur andat least one member must be either nitrogen, oxygen or sulfur; wherein,optionally, the ring contains zero to one unsaturated bonds, and,optionally, when the ring is of 6 or 7 members, it contains up to 2unsaturated bonds. The carbon atom ring members that form a heterocyclering may be fully saturated or partially saturated. The term“heterocyclyl” also includes two 5 membered monocyclic heterocycloalkylgroups bridged to form a bicyclic ring. Such groups are not consideredto be fully aromatic and are not referred to as heteroaryl groups. Whena heterocycle is bicyclic, both rings of the heterocycle arenon-aromatic and at least one of the rings contains a heteroatom ringmember. Examples of heterocycle groups include, and are not limited to,pyrrolinyl (including 2H-pyrrole, 2-pyrrolinyl or 3-pyrrolinyl),pyrrolidinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl,piperidinyl, morpholinyl, thiomorpholinyl, and piperazinyl. Unlessotherwise noted, the heterocycle is attached to its pendant group at anyheteroatom or carbon atom that results in a stable structure.

The term “benzo-fused heterocyclyl” refers to a 5 to 7 memberedmonocyclic heterocycle ring fused to a benzene ring. The heterocyclering contains carbon atoms and from 1 to 4 heteroatoms independentlyselected from the group consisting of N, O, and S. The carbon atom ringmembers that form the heterocycle ring may be fully saturated orpartially saturated. Unless otherwise noted, benzo-fused heterocyclering is attached to its pendant group at a carbon atom of the benzenering.

The term “aryl” refers to an unsaturated, aromatic monocyclic orbicyclic ring of 6 to 10 carbon members. Examples of aryl rings includephenyl and naphthalenyl.

The term “heteroaryl” refers to an aromatic monocyclic or bicyclicaromatic ring system having 5 to 10 ring members and which containscarbon atoms and from 1 to 4 heteroatoms independently selected from thegroup consisting of N, O, and S. Included within the term heteroaryl arearomatic rings of 5 or 6 members wherein the ring consists of carbonatoms and has at least one heteroatom member. Suitable heteroatomsinclude nitrogen, oxygen, and sulfur. In the case of 5 membered rings,the heteroaryl ring preferably contains one member of nitrogen, oxygenor sulfur and, in addition, up to 3 additional nitrogens. In the case of6 membered rings, the heteroaryl ring preferably contains from 1 to 3nitrogen atoms. For the case wherein the 6 membered ring has 3nitrogens, at most 2 nitrogen atoms are adjacent. Examples of heteroarylgroups include furyl, thienyl, pyrrolyl, oxazolyl, thiazolyl,imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl,thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, indolyl,isoindolyl, benzofuryl, benzothienyl, indazolyl, benzimidazolyl,benzothiazolyl, benzoxazolyl, benzisoxazolyl, benzothiadiazolyl,benzotriazolyl, quinolinyl, isoquinolinyl and quinazolinyl. Unlessotherwise noted, the heteroaryl is attached to its pendant group at anyheteroatom or carbon atom that results in a stable structure.

The term “halogen” or “halo” refers to fluorine, chlorine, bromine andiodine.

The term “formyl” refers to the group —C(═O)H.

The term “oxo” refers to the group (═O).

Whenever the term “alkyl” or “aryl” or either of their prefix rootsappear in a name of a substituent (e.g., arylalkyl, alkylamino) the nameis to be interpreted as including those limitations given above for“alkyl” and “aryl.” Designated numbers of carbon atoms (e.g., C₁-C₆)refer independently to the number of carbon atoms in an alkyl moiety, anaryl moiety, or in the alkyl portion of a larger substituent in whichalkyl appears as its prefix root. For alkyl and alkoxy substituents, thedesignated number of carbon atoms includes all of the independentmembers included within a given range specified. For example C₁₋₆ alkylwould include methyl, ethyl, propyl, butyl, pentyl and hexylindividually as well as sub-combinations thereof (e.g., C₁₋₂, C₁₋₃,C₁₋₄, C₁₋₅, C₂₋₆, C₃₋₆, C₄₋₆, C₅₋₆, C₂₋₅, etc.).

In general, under standard nomenclature rules used throughout thisdisclosure, the terminal portion of the designated side chain isdescribed first followed by the adjacent functionality toward the pointof attachment. Thus, for example, a “C₁-C₆ alkylcarbonyl” substituentrefers to a group of the formula:

The term “R” at a stereocenter designates that the stereocenter ispurely of the R-configuration as defined in the art; likewise, the term“S” means that the stereocenter is purely of the S-configuration. Asused herein, the terms “*R” or “*S” at a stereocenter are used todesignate that the stereocenter is of pure but unknown configuration. Asused herein, the term “RS” refers to a stereocenter that exists as amixture of the R- and S-configurations. Similarly, the terms “*RS” or“*SR” refer to a stereocenter that exists as a mixture of the R- andS-configurations and is of unknown configuration relative to anotherstereocenter within the molecule.

Compounds containing one stereocenter drawn without a stereo bonddesignation are a mixture of 2 enantiomers. Compounds containing 2stereocenters both drawn without stereo bond designations are a mixtureof 4 diastereomers. Compounds with 2 stereocenters both labeled “RS” anddrawn with stereo bond designations are a 2-component mixture withrelative stereochemistry as drawn. Compounds with 2 stereocenters bothlabeled “*RS” and drawn with stereo bond designations are a 2-componentmixture with relative stereochemistry unknown. Unlabeled stereocentersdrawn without stereo bond designations are a mixture of the R- andS-configurations. For unlabeled stereocenters drawn with stereo bonddesignations, the absolute stereochemistry is as depicted.

Unless otherwise noted, it is intended that the definition of anysubstituent or variable at a particular location in a molecule beindependent of its definitions elsewhere in that molecule. It isunderstood that substituents and substitution patterns on the compoundsof Formula (I) can be selected by one of ordinary skill in the art toprovide compounds that are chemically stable and that can be readilysynthesized by techniques known in the art as well as those methods setforth herein.

The term “subject” refers to an animal, preferably a mammal, mostpreferably a human, who has been the object of treatment, observation orexperiment.

The term “therapeutically effective amount” refers to an amount of anactive compound or pharmaceutical agent, including a compound of thepresent invention, which elicits the biological or medicinal response ina tissue system, animal or human that is being sought by a researcher,veterinarian, medical doctor or other clinician, which includesalleviation or partial alleviation of the symptoms of the disease,syndrome, condition, or disorder being treated.

The term “composition” refers to a product that includes the specifiedingredients in therapeutically effective amounts, as well as any productthat results, directly, or indirectly, from combinations of thespecified ingredients in the specified amounts.

The term “N-Type calcium channel blocker” is intended to encompass acompound that interacts with the N-Type calcium channel to substantiallyreduce or eliminate its functional activity, thereby decreasing the flowof calcium ions through the channel and the rise of intracellularcalcium concentrations.

The term “N-Type calcium channel-modulated” is used to refer to thecondition of being affected by the modulation of the N-Type calciumchannel, including the condition of being affected by the inhibition ofthe N-Type calcium channel, such as, for example, pain, the diseasesthat lead to such pain and treatments that lead to the reduction of suchpain.

As used herein, unless otherwise noted, the term “affect” or “affected”(when referring to a disease, syndrome, condition or disorder that isaffected by the inhibition of N-Type calcium channel) shall include areduction in the frequency and/or severity of one or more symptoms ormanifestations of said disease, syndrome, condition or disorder and/orinclude the prevention of the development of one or more symptoms ormanifestations of said disease, syndrome, condition or disorder or thedevelopment of the disease, condition, syndrome or disorder.

The compounds of Formula (I) are useful in methods for treating,ameliorating and/or preventing a disease, a syndrome, a condition or adisorder that is affected by the inhibition of N-Type calcium channel.Such methods comprise, consist of and/or consist essentially ofadministering to a subject, including an animal, a mammal, and a humanin need of such treatment, amelioration and/or prevention, atherapeutically effective amount of a compound of Formula (I), or anenantiomer, diastereomer, solvate or pharmaceutically acceptable saltform thereof. In particular, the compounds of Formula (I) are useful fortreating, ameliorating and/or preventing pain as well as diseases,syndromes, conditions or disorders causing such pain. More particularly,the compounds of Formula (I) are useful for treating, amelioratingand/or preventing acute pain, inflammatory pain and/or neuropathic pain,comprising administering to a subject in need thereof a therapeuticallyeffective amount of a compound of Formula (I), as herein defined.

Acute pain, as used herein, refers to pain that comes on quickly, can beof varying severity but is self-limiting and of relatively shortduration. Examples of acute pain include, but are not limited to,post-operative pain, post-surgical pain, toothache, burn, sunburn,insect/animal bites and stings, headache and/or any pain associated withacute trauma or injury.

Inflammatory pain refers to pain arising from an inflammatory disease,condition, syndrome or disorder, including but not limited toinflammatory bowel disease, irritable bowel syndrome, visceral pain,migraine, post-operative pain, osteoarthritis, rheumatoid arthritis,back pain, low back pain, joint pain, abdominal pain, chest pain, laborpain, musculoskeletal diseases, skin diseases, toothache, pyresis, burn,sunburn, snake bite, venomous snake bite, spider bite, insect sting,neurogenic or overactive bladder, interstitial cystitis, urinary tractinfection, rhinitis, contact dermatitis/hypersensitivity, itch, eczema,pharyngitis, mucositis, enteritis, irritable bowel syndrome,cholecystitis, pancreatitis, postmastectomy pain syndrome, menstrualpain, endometriosis, pain due to physical trauma, headache, sinusheadache, tension headache or arachnoiditis.

A further embodiment of the present invention is directed to a methodfor treating, ameliorating and/or preventing neuropathic pain.Neuropathic pain refers to a disease, syndrome, condition and/ordisorder involving damage to the peripheral or central nervous system,including cancer pain, neurological disorders, spine and peripheralnerve surgery, brain tumor, traumatic brain injury (TBI),chemotherapy-induced pain, pain chronification, radicular pain, HIVpain, spinal cord trauma, chronic pain syndrome, fibromyalgia, chronicfatigue syndrome, lupus, sarcoidosis, peripheral neuropathy, bilateralperipheral neuropathy, diabetic neuropathy, central pain, neuropathiesassociated with spinal cord injury, stroke, amyotrophic lateralsclerosis (ALS), Parkinson's disease, multiple sclerosis, sciaticneuritis, mandibular joint neuralgia, peripheral neuritis, polyneuritis,stump pain, phantom limb pain, bony fractures, oral neuropathic pain,Charcot's pain, complex regional pain syndrome I and II (CRPS I/II),radiculopathy, Guillain-Barre syndrome, meralgia paresthetica,burning-mouth syndrome, optic neuritis, postfebrile neuritis, migratingneuritis, segmental neuritis, Gombault's neuritis, neuronitis,cervicobrachial neuralgia, cranial neuralgia, geniculate neuralgia,glossopharyngial neuralgia, migrainous neuralgia, idiopathic neuralgia,intercostals neuralgia, mammary neuralgia, Morton's neuralgia,nasociliary neuralgia, occipital neuralgia, post-herpetic neuralgia,causalgia, red neuralgia, Sluder's neuralgia, splenopalatine neuralgia,supraorbital neuralgia, trigeminal neuralgia, vulvodynia, or vidianneuralgia.

Embodiments of the present invention include a compound of Formula (I)

wherein

-   -   a) R¹ is selected from the group consisting of C₁₋₄alkyl,        C₁₋₄alkoxy, and trifluoromethoxy;    -   b) R¹ is selected from the group consisting of C₁₋₄alkoxy, and        trifluoromethoxy;    -   c) R² is hydrogen;    -   d) R³ is hydrogen or chloro;    -   e) R³ is hydrogen;    -   f) R⁴ is selected from the group consisting of C₁₋₄alkyl,        C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino;    -   g) R⁶ is chloro;    -   h) G is selected from the group consisting of C₁₋₆alkyl,        hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, 2-methylprop-1-enyl, cyano,        phenoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl,        4,4-dimethyl-cyclohexyl, C₃₋₆cycloalkyl(C₁₋₄)alkyl,        C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,        di(C₁₋₄alkyl)aminocarbonyloxy,        di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,        C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,        C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,        di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,        C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,        C₁₋₄alkylsulfonylamino-C₁₋₄alkyl,        C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,        di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl,        trifluoromethylcarbonylamino,        trifluoromethylcarbonylamino-C₁₋₄alkyl,        2,5-dioxo-pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl,        3,3-difluoro-pyrrolidin-1-yl, 3,3-diethyl-pyrrolidin-1-yl,        3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy, trimethylsilyloxy,        oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,        2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,        morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,        (1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,        tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy,        1,2,3,4-tetrahydroquinolin-3-yl, aminocarbonyl,        -   pyridin-3-yl optionally substituted with one to two            substituents each independently selected from the group            consisting of C₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl,            and C₁₋₄alkoxycarbonyl;        -   1H-1,2,3-triazol-1-yl optionally substituted with one to two            substituents each independently selected from the group            consisting of C₁₋₄alkyl, C₃₋₆-cycloalkyl,            C₁₋₄alkoxycarbonyl, C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and            trimethylsilyl;        -   1H-imidazol-1-yl optionally independently substituted with            one to three C₁₋₃alkyl substituents;        -   and        -   a spirofused heterocyclyl independently selected from the            group consisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,            4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,            4,6-dimethyl-1,3-dioxan-2-yl,            (3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,            5,5-dimethyl-1,3-dioxan-2-yl, and            (3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;    -   i) G is selected from the group consisting of C₁₋₆alkyl,        C₁₋₆alkoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyloxy,        C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,        di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,        C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄alkoxy,        C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,        di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,        C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,        C₁₋₄alkylsulfonylamino-C₁₋₄alkyl,        C₁₋₄alkylcarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,        2,5-dioxo-pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl,        3,3-difluoro-pyrrolidin-1-yl, 3,3-diethyl-pyrrolidin-1-yl,        3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy, trimethylsilyloxy,        oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,        2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,        morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,        (1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,        tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy,        -   pyridin-3-yl optionally substituted with a substituent            independently selected from the group consisting of            C₁₋₄alkyl, cyclopropyl, and C₁₋₄alkoxycarbonyl;        -   1H-1,2,3-triazol-1-yl optionally substituted with one to two            substituents each independently selected from the group            consisting of C₁₋₄alkyl, C₃₋₆-cycloalkyl,            C₁₋₄alkoxycarbonyl, and trimethylsilyl;        -   1H-imidazol-1-yl optionally independently substituted with            one to three C₁₋₃alkyl substituents;        -   and        -   a spirofused heterocyclyl independently selected from the            group consisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,            4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,            4,6-dimethyl-1,3-dioxan-2-yl,            (3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,            5,5-dimethyl-1,3-dioxan-2-yl, and            (3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;

and any combination of embodiments a) through i) above, provided that itis understood that combinations in which different embodiments of thesame substituent would be combined are excluded;

and enantiomers, diastereomers, solvates and pharmaceutically acceptablesalts thereof.

An embodiment of the present invention is directed to a compound ofFormula (I)

wherein

R¹ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy, andtrifluoromethoxy;

R² is hydrogen; or, R² may be taken with R¹ and the phenyl ring to whichR¹ and R² are both attached to form 2,3-dihydrobenzofuran-7-yl;

R³ is hydrogen or chloro;

Q is selected from the group consisting of Q1, Q2, and Q3;

R⁴ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,cyano, chloro, and di(C₁₋₄alkyl)amino;

R⁵ and R⁶ are each independently selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino;

G is selected from the group consisting of C₁₋₆alkyl,hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, 2-methylprop-1-enyl, cyano, phenoxy,C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl, 4,4-dimethyl-cyclohexyl,C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl,

pyridin-3-yl optionally substituted with morpholin-4-yl or one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl, and C₁₋₄alkoxycarbonyl;

1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄-alkoxycarbonyl,C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl;

1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents;

and

a spirofused heterocyclyl independently selected from the groupconsisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;

provided that a compound of Formula (I) is other than

-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;    or-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];    and enantiomers, diastereomers, solvates and pharmaceutically    acceptable salts thereof.

An embodiment of the present invention is directed to a compound ofFormula (I)

wherein

R¹ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy, andtrifluoromethoxy;

R² is hydrogen; or, R² may be taken with R¹ and the phenyl ring to whichR¹ and R² are both attached to form 2,3-dihydrobenzofuran-7-yl;

R³ is hydrogen;

Q is selected from the group consisting of Q1, Q2, and Q3;

R⁴ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,cyano, chloro, and di(C₁₋₄alkyl)amino;

R⁵ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,cyano, chloro, and di(C₁₋₄alkyl)amino;

R⁶ is chloro;

G is selected from the group consisting of C₁₋₆alkyl,hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, 2-methylprop-1-enyl, cyano, phenoxy,C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl, 4,4-dimethyl-cyclohexyl,C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl,

pyridin-3-yl optionally substituted with one to two substituents eachindependently selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, chloro, cyclopropyl, and C₁₋₄alkoxycarbonyl;

1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl,C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl;

1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents;

and

a spirofused heterocyclyl independently selected from the groupconsisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;

provided that a compound of Formula (I) is other than

-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;    or-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];    and enantiomers, diastereomers, solvates and pharmaceutically    acceptable salts thereof.

An embodiment of the present invention is directed to a compound ofFormula (I)

wherein

R¹ is selected from the group consisting of C₁₋₄alkoxy andtrifluoromethoxy;

R² is hydrogen;

R³ is hydrogen;

Q is selected from the group consisting of Q1, Q2, and Q3;

R⁴ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,cyano, chloro, and di(C₁₋₄alkyl)amino;

R⁵ is selected from the group consisting of C₁₋₄alkyl, C₁₋₄alkoxy,cyano, chloro, and di(C₁₋₄alkyl)amino;

R⁶ is chloro;

G is selected from the group consisting of C₁₋₆alkyl, C₁₋₆alkoxy,C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,trifluoromethylcarbonylamino, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄alkoxy,

pyridin-3-yl optionally substituted with a substituent independentlyselected from the group consisting of C₁₋₄alkyl, cyclopropyl, andC₁₋₄alkoxycarbonyl;

1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl, and trimethylsilyl;

1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents;

and

a spirofused heterocyclyl independently selected from the groupconsisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl;

provided that a compound of Formula (I) is other than

-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;    or-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];    and enantiomers, diastereomers, solvates and pharmaceutically    acceptable salts thereof.

Further embodiments of the present invention are directed to a compoundof Formula (I)

selected from the group consisting of

-   2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethanol;-   2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl    morpholine-4-carboxylate;-   2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl    dimethylcarbamate;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-prop-2-en-1-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   ethyl    3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxylate;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxamide;-   N-{[2-(2-methoxyphenyl)-3-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;-   N-{[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;-   2-(2-methoxyphenyl)-3-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carbonitrile;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carbonitrile;-   N-{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}methanesulfonamide;-   N-{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}acetamide;-   tert-butyl{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}carbamate;-   ethyl    3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxylate;-   tert-butyl{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methylidene}carbamate;-   tert-butyl{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}carbamate;-   [3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl    diethylcarbamate;-   N-{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;-   N-{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}-2,2,2-trifluoroacetamide;-   tert-butyl(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)carbamate;-   N-(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)methanesulfonamide;-   3-(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)-1,1-dimethylurea;-   3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    dimethylcarbamate;-   3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylmorpholine-4-carboxylate;-   3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ol;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ol;-   3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    dimethylcarbamate;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    morpholine-4-carboxylate;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    dimethylcarbamate;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    morpholine-4-carboxylate;-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methanesulfonamide;-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]propane-2-sulfonamide;-   N′-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N-dimethylsulfamide;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;-   N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N-methylmethanesulfonamide;-   1-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyrrolidine-2,5-dione;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   1-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyrrolidin-2-one;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-1,2,3-triazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]propane-2-sulfonamide;-   N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-2,2,2-trifluoroacetamide;-   N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;-   N′-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N-dimethylsulfamide;-   N-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;-   (5R)-3-(4-chlorophenyl)-5-methoxy-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   N-[(5S)-3-(4-chlorophenyl)-2-(2,3-dihydro-1-benzofuran-7-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;-   N-[(5S)-3-(4-chlorophenyl)-2-(2,3-dihydro-1-benzofuran-7-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N-methylpropane-2-sulfonamide;-   2-(4-Chloro-2-methoxyphenyl)-3-(4-chlorophenyl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   (5Z)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one    oxime;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   (5R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    2-ethylbutanoate;-   N-[(5R)-2-(2-Methoxyphenyl)-3-(6-methoxypyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;-   N-{(5R)-2-(2-Methoxyphenyl)-3-[6-(1-methylethoxy)pyridin-3-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}-N,N′,N′-trimethylsulfamide;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-phenoxy-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-[6-(1-methylethoxy)pyridin-3-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(pyridin-2-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(6-morpholin-4-ylpyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-pyridin-3-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-5-(4,4-dimethylcyclohexyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1,2,3,4-tetrahydroquinoline;-   Ethyl    5-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyridine-3-carboxylate;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(1-methylethoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-morpholin-4-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-[(trimethylsilyl)oxy]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    2-ethylbutanoate;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   (5S)-3-(4-chlorophenyl)-5-(2-ethylbutoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(6-methylpyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-5-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   5-[2-Chloro-6-(1-methylethyl)pyridin-3-yl]-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(tetrahydro-2H-pyran-2-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-   3-(4-chlorophenyl)-5-(6-cyclopropylpyridin-3-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    cyclohexanecarboxylate;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    cyclopentanecarboxylate;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    cyclobutanecarboxylate;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    2-methylpropanoate;-   (5S)-3-(4-chlorophenyl)-5-(cyclohexylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-5-(cyclopentylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-5-(cyclobutylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(2-methylpropoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl    tetrahydro-2H-pyran-4-carboxylate;-   (5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-5-(cyclohexyloxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-5-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   (5S)-3-(4-chlorophenyl)-5-(cyclopentyloxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   4-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]benzonitrile;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(1-methylethyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   4-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]-N,N-dimethylaniline;-   3-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   2-(2-methoxyphenyl)-5′,5′-dimethyl-3-(6-methylpyridin-3-yl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   2-(2-methoxyphenyl)-3-(6-methoxypyridin-3-yl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   5-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]-N,N-dimethylpyridin-2-amine;-   (4′R,5′R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];    (4′S,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   (4′R,6′R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,6′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   (4′S,6′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,6′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   (4′R,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   (4′R,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   3-(4-chlorophenyl)-5-cyclohexyl-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   4-[2-(2-methoxyphenyl)-5-(2-methylpropyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[5-(cyclohexylmethyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]-N,N-dimethylaniline;-   3-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-3-(6-methylpyridin-3-yl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   5-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]-N,N-dimethylpyridin-2-amine;-   4-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]benzonitrile;-   (3aR,7aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,3a,4,5,6,6′,7,7a-octahydro-4′H-spiro[1,3-benzodioxole-2,5′-cyclopenta[c]pyrazole];-   (3aS,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];-   (3aR,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];-   (3aR,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];-   3-(4-chlorophenyl)-5-(2,6-dimethylmorpholin-4-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(4-methylpiperidin-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-5-(3,3-diethylpyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-5-(3,3-dimethylpyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(5-chlorothiophen-2-yl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];-   3-(5-chlorothiophen-2-yl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];-   3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-pyrrolidin-1-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   3-(4-chlorophenyl)-5-(3,3-difluoropyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;-   4-[(5S)-5-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   methyl    1-[(5S)-3-(4-cyanophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1H-1,2,3-triazole-4-carboxylate;-   4-[(5S)-5-[4-(1-hydroxy-1-methylethyl)-1H-1,2,3-triazol-1-yl]-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-{(5S)-2-(2-methoxyphenyl)-5-[4-(2-methylpropyl)-1H-1,2,3-triazol-1-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl}benzonitrile;-   {1-[(5S)-3-(4-cyanophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1H-1,2,3-triazol-4-yl}methyl    acetate;-   4-[(5S)-5-[4-(methoxymethyl)-1H-1,2,3-triazol-1-yl]-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(4-tert-butyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(4,5-dimethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-2-(2-methoxyphenyl)-5-(2,4,5-trimethyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(2-ethyl-4,5-dimethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(2-ethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-2-(2-methoxyphenyl)-5-(2-methyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(4,5-diethyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-2-(2-methoxyphenyl)-5-(2,4,5-triethyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(4,5-diethyl-2-methyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;-   4-[(5S)-5-(4,5-diethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;    and pharmaceutically acceptable salt forms thereof.

For use in medicine, salts of compounds of Formula (I) refer tonon-toxic “pharmaceutically acceptable salts.” Other salts may, however,be useful in the preparation of compounds of Formula (I) or of theirpharmaceutically acceptable salts thereof. Suitable pharmaceuticallyacceptable salts of compounds of Formula (I) include acid addition saltswhich can, for example, be formed by mixing a solution of the compoundwith a solution of a pharmaceutically acceptable acid such ashydrochloric acid, sulfuric acid, fumaric acid, maleic acid, succinicacid, acetic acid, benzoic acid, citric acid, tartaric acid, carbonicacid or phosphoric acid. Furthermore, where the compounds of Formula (I)carry an acidic moiety, suitable pharmaceutically acceptable saltsthereof may include alkali metal salts, such as sodium or potassiumsalts; alkaline earth metal salts, such as calcium or magnesium salts;and salts formed with suitable organic ligands, such as quaternaryammonium salts. Thus, representative pharmaceutically acceptable saltsinclude acetate, benzenesulfonate, benzoate, bicarbonate, bisulfate,bitartrate, borate, bromide, calcium edetate, camsylate, carbonate,chloride, clavulanate, citrate, dihydrochloride, edetate, edisylate,estolate, esylate, fumarate, gluceptate, gluconate, glutamate,glycollylarsanilate, hexylresorcinate, hydrabamine, hydrobromide,hydrochloride, hydroxynaphthoate, iodide, isothionate, lactate,lactobionate, laurate, malate, maleate, mandelate, mesylate,methylbromide, methylnitrate, methylsulfate, mucate, napsylate, nitrate,N-methylglucamine ammonium salt, oleate, pamoate (embonate), palmitate,pantothenate, phosphate/diphosphate, polygalacturonate, salicylate,stearate, sulfate, subacetate, succinate, tannate, tartrate, teoclate,tosylate, triethiodide and valerate.

Representative acids and bases that may be used in the preparation ofpharmaceutically acceptable salts include acids including acetic acid,2,2-dichloroactic acid, acylated amino acids, adipic acid, alginic acid,ascorbic acid, L-aspartic acid, benzenesulfonic acid, benzoic acid,4-acetamidobenzoic acid, (+)-camphoric acid, camphorsulfonic acid,(+)-(1S)-camphor-10-sulfonic acid, capric acid, caproic acid, caprylicacid, cinnamic acid, citric acid, cyclamic acid, dodecylsulfuric acid,ethane-1,2-disulfonic acid, ethanesulfonic acid,2-hydroxy-ethanesulfonic acid, formic acid, fumaric acid, galactaricacid, gentisic acid, glucoheptonic acid, D-gluconic acid, D-glucoronicacid, L-glutamic acid, α-oxo-glutaric acid, glycolic acid, hippuricacid, hydrobromic acid, hydrochloric acid, (+)-L-lactic acid,(±)-DL-lactic acid, lactobionic acid, maleic acid, (−)-L-malic acid,malonic acid, (±)-DL-mandelic acid, methanesulfonic acid,naphthalene-2-sulfonic acid, naphthalene-1,5-disulfonic acid,1-hydroxy-2-naphthoic acid, nicotinic acid, nitric acid, oleic acid,orotic acid, oxalic acid, palmitic acid, pamoic acid, phosphoric acid,L-pyroglutamic acid, salicylic acid, 4-amino-salicylic acid, sebaicacid, stearic acid, succinic acid, sulfuric acid, tannic acid,(+)-L-tartaric acid, thiocyanic acid, p-toluenesulfonic acid andundecylenic acid; and bases including ammonia, L-arginine, benethamine,benzathine, calcium hydroxide, choline, deanol, diethanolamine,diethylamine, 2-(diethylamino)-ethanol, ethanolamine, ethylenediamine,N-methylglucamine, hydrabamine, 1H-imidazole, L-lysine, magnesiumhydroxide, 4-(2-hydroxyethyl)-morpholine, piperazine, potassiumhydroxide, 1-(2-hydroxyethyl)-pyrrolidine, sodium hydroxide,triethanolamine, tromethamine and zinc hydroxide.

Embodiments of the present invention include prodrugs of compounds ofFormula (I). In general, such prodrugs will be functional derivatives ofthe compounds that are readily convertible in vivo into the requiredcompound. Thus, in the methods of treating or preventing embodiments ofthe present invention, the term “administering” encompasses thetreatment or prevention of the various diseases, conditions, syndromesand disorders described with the compound specifically disclosed or witha compound that may not be specifically disclosed, but which converts tothe specified compound in vivo after administration to a patient.Conventional procedures for the selection and preparation of suitableprodrug derivatives are described, for example, in “Design of Prodrugs”,ed. H. Bundgaard, Elsevier, 1985.

Where the compounds according to embodiments of this invention have atleast one chiral center, they may accordingly exist as enantiomers.Where the compounds possess two or more chiral centers, they mayadditionally exist as diastereomers. It is to be understood that allsuch isomers and mixtures thereof are encompassed within the scope ofthe present invention. Furthermore, some of the crystalline forms forthe compounds may exist as polymorphs and as such are intended to beincluded in the present invention. In addition, some of the compoundsmay form solvates with water (i.e., hydrates) or common organicsolvents, and such solvates are also intended to be encompassed withinthe scope of this invention. The skilled artisan will understand thatthe term compound as used herein, is meant to include solvated compoundsof Formula (I).

Where the processes for the preparation of the compounds according tocertain embodiments of the invention give rise to mixture ofstereoisomers, these isomers may be separated by conventional techniquessuch as preparative chromatography. The compounds may be prepared inracemic form, or individual enantiomers may be prepared either byenantiospecific synthesis or by resolution. The compounds may, forexample, be resolved into their component enantiomers by standardtechniques, such as the formation of diastereomeric pairs by saltformation with an optically active acid, such as(−)-di-p-toluoyl-d-tartaric acid and/or (+)-di-p-toluoyl-l-tartaric acidfollowed by fractional crystallization and regeneration of the freebase. The compounds may also be resolved by formation of diastereomericesters or amides, followed by chromatographic separation and removal ofthe chiral auxiliary. Alternatively, the compounds may be resolved usinga chiral HPLC column.

One embodiment of the present invention is directed to a composition,including a pharmaceutical composition, comprising, consisting of,and/or consisting essentially of the (+)-enantiomer of a compound ofFormula (I) wherein said composition is substantially free from the(−)-isomer of said compound. In the present context, substantially freemeans less than about 25%, preferably less than about 10%, morepreferably less than about 5%, even more preferably less than about 2%and even more preferably less than about 1% of the (−)-isomer calculatedas.

${{\%( + )} - {enantiomer}} = {\frac{\left( {{{mass}( + )} - {enantiomer}} \right)}{\left( {{{mass}( + )} - {enantiomer}} \right) + \left( {{{mass}( - )} - {enantiomer}} \right)} \times 100.}$

Another embodiment of the present invention is a composition, includinga pharmaceutical composition, comprising, consisting of, and consistingessentially of the (−)-enantiomer of a compound of Formula (I) whereinsaid composition is substantially free from the (+)-isomer of saidcompound. In the present context, substantially free from means lessthan about 25%, preferably less than about 10%, more preferably lessthan about 5%, even more preferably less than about 2% and even morepreferably less than about 1% of the (+)-isomer calculated as

${{\%( - )} - {enantiomer}} = {\frac{\left( {{{mass}( - )} - {enantiomer}} \right)}{\left( {{{mass}( + )} - {enantiomer}} \right) + \left( {{{mass}( - )} - {enantiomer}} \right)} \times 100.}$

During any of the processes for preparation of the compounds of thevarious embodiments of the present invention, it may be necessary and/ordesirable to protect sensitive or reactive groups on any of themolecules concerned. This may be achieved by means of conventionalprotecting groups, such as those described in Protective Groups inOrganic Chemistry, Second Edition, J. F. W. McOmie, Plenum Press, 1973;T. W. Greene & P. G. M. Wuts, Protective Groups in Organic Synthesis,John Wiley & Sons, 1991; and T. W. Greene & P. G. M. Wuts, ProtectiveGroups in Organic Synthesis, Third Edition, John Wiley & Sons, 1999. Theprotecting groups may be removed at a convenient subsequent stage usingmethods known from the art.

Even though the compounds of embodiments of the present invention(including their pharmaceutically acceptable salts and pharmaceuticallyacceptable solvates) can be administered alone, they will generally beadministered in admixture with a pharmaceutically acceptable carrier, apharmaceutically acceptable excipient and/or a pharmaceuticallyacceptable diluent selected with regard to the intended route ofadministration and standard pharmaceutical or veterinary practice. Thus,particular embodiments of the present invention are directed topharmaceutical and veterinary compositions comprising compounds ofFormula (I) and at least one pharmaceutically acceptable carrier,pharmaceutically acceptable excipient, and/or pharmaceuticallyacceptable diluent.

By way of example, in the pharmaceutical compositions of embodiments ofthe present invention, the compounds of Formula (I) may be admixed withany suitable binder(s), lubricant(s), suspending agent(s), coatingagent(s), solubilizing agent(s), and combinations thereof.

Solid oral dosage forms, such as tablets or capsules, containing thecompounds of the present invention may be administered in at least onedosage form at a time, as appropriate. It is also possible to administerthe compounds in sustained release formulations.

Additional oral forms in which the present inventive compounds may beadministered include elixirs, solutions, syrups, and suspensions; eachoptionally containing flavoring agents and coloring agents.

Alternatively, compounds of Formula (I) can be administered byinhalation (intratracheal or intranasal) or in the form of a suppositoryor pessary, or they may be applied topically in the form of a lotion,solution, cream, ointment or dusting powder. For example, they can beincorporated into a cream comprising, consisting of, and/or consistingessentially of an aqueous emulsion of polyethylene glycols or liquidparaffin. They can also be incorporated, at a concentration of betweenabout 1% and about 10% by weight of the cream, into an ointmentcomprising, consisting of, and/or consisting essentially of a white waxor white soft paraffin base together with any stabilizers andpreservatives as may be required. An alternative means of administrationincludes transdermal administration by using a skin or transdermalpatch.

The pharmaceutical compositions of the present invention (as well as thecompounds of the present invention alone) can also be injectedparenterally, for example intracavernosally, intravenously,intramuscularly, subcutaneously, intradermally or intrathecally. In thiscase, the compositions will also include at least one of a suitablecarrier, a suitable excipient, and a suitable diluent.

For parenteral administration, the pharmaceutical compositions of thepresent invention are best used in the form of a sterile aqueoussolution that may contain other substances, for example, enough saltsand monosaccharides to make the solution isotonic with blood.

For buccal or sublingual administration, the pharmaceutical compositionsof the present invention may be administered in the form of tablets orlozenges, which can be formulated in a conventional manner.

By way of further example, pharmaceutical compositions containing atleast one of the compounds of Formula (I) as the active ingredient canbe prepared by mixing the compound(s) with a pharmaceutically acceptablecarrier, a pharmaceutically acceptable diluent, and/or apharmaceutically acceptable excipient according to conventionalpharmaceutical compounding techniques. The carrier, excipient, anddiluent may take a wide variety of forms depending upon the desiredroute of administration (e.g., oral, parenteral, etc.). Thus for liquidoral preparations, such as suspensions, syrups, elixirs and solutions,suitable carriers, excipients and diluents include water, glycols, oils,alcohols, flavoring agents, preservatives, stabilizers, coloring agentsand the like; for solid oral preparations, such as powders, capsules andtablets, suitable carriers, excipients and diluents include starches,sugars, diluents, granulating agents, lubricants, binders,disintegrating agents and the like. Solid oral preparations also may beoptionally coated with substances, such as, sugars, or beenterically-coated so as to modulate the major site of absorption anddisintegration. For parenteral administration, the carrier, excipientand diluent will usually include sterile water, and other ingredientsmay be added to increase solubility and preservation of the composition.Injectable suspensions or solutions may also be prepared utilizingaqueous carriers along with appropriate additives, such as solubilizersand preservatives.

A therapeutically effective amount of a compound of Formula (I) or apharmaceutical composition thereof includes a dose range from about 0.1mg to about 3000 mg, or any particular amount or range therein, inparticular from about 1 mg to about 1000 mg, or any particular amount orrange therein; or, more particularly, from about 10 mg to about 500 mg,or any particular amount or range therein, of active ingredient in aregimen of about 1 to about 4 times per day for an average (70 kg)human; although, it is apparent to one skilled in the art that thetherapeutically effective amount for a compound of Formula (I) will varyas will the diseases, syndromes, conditions, and disorders beingtreated.

For oral administration, a pharmaceutical composition is preferablyprovided in the form of tablets containing about 0.01, about 10, about50, about 100, about 150, about 200, about 250, and about 500 milligramsof a compound of Formula (I).

Advantageously, a compound of Formula (I) may be administered in asingle daily dose, or the total daily dosage may be administered individed doses of two, three and four times daily.

Optimal dosages of a compound of Formula (I) to be administered may bereadily determined and will vary with the particular compound used, themode of administration, the strength of the preparation and theadvancement of the disease, syndrome, condition or disorder. Inaddition, factors associated with the particular subject being treated,including subject gender, age, weight, diet and time of administration,will result in the need to adjust the dose to achieve an appropriatetherapeutic level and desired therapeutic effect. The above dosages arethus exemplary of the average case. There can be, of course, individualinstances wherein higher or lower dosage ranges are merited, and suchare within the scope of this invention.

Compounds of Formula (I) may be administered in any of the foregoingcompositions and dosage regimens or by means of those compositions anddosage regimens established in the art whenever use of a compound ofFormula (I) is required for a subject in need thereof.

As N-Type calcium channel blockers, the compounds of Formula (I) areuseful in methods for treating and/or preventing a disease, a syndrome,a condition or a disorder in a subject, including an animal, a mammaland a human in which the disease, the syndrome, the condition or thedisorder is affected by the modulation of the N-Type calcium channel.Such methods comprise, consist of and/or consist essentially ofadministering to a subject, including an animal, a mammal, and a humanin need of such treatment or prevention a therapeutically effectiveamount of a compound, salt or solvate of Formula (I). In particular, thecompounds of Formula (I) are useful for preventing or treating pain,such as inflammatory pain or neuropathic pain, or diseases, syndromes,conditions or disorders causing such pain.

General Synthetic Methods

Representative compounds of the present invention can be synthesized inaccordance with the general synthetic methods described below andillustrated in the schemes and examples that follow. Since the schemesare an illustration, the invention should not be construed as beinglimited by the chemical reactions and conditions described in theschemes. The various starting materials used in the schemes and examplesare commercially available or may be prepared by methods well within theskill of persons versed in the art. The variables are as defined herein.

Abbreviations used in the instant specification, particularly theschemes and examples, are as follows:

-   -   ACN acetonitrile    -   AcOH glacial acetic acid    -   aq. aqueous    -   Bn or Bzl benzyl    -   Boc tert-butyloxycarbonyl    -   conc. concentrated    -   DBU 1,8-diazabicyclo[5.4.0]undec-7-ene    -   DCC N,N′-dicyclohexyl-carbodiimide    -   DCE 1,2-dichloroethane    -   DCM dichloromethane    -   DIBALH diisobutylaluminum hydride    -   DIPEA or DIEA diisopropyl-ethyl amine    -   DMF N,N-dimethylformamide    -   DMSO dimethylsulfoxide    -   EA ethyl acetate    -   EDCI 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide    -   EGTA ethylene glycol tetraacetic acid    -   ESI electrospray ionization    -   EtOAc or EA ethyl acetate    -   EtOH ethanol    -   h or hr(s) hour or hours    -   HEK human embryonic kidney    -   HEPES (4-(2-hydroxyethyl)-1-piperazineethane sulfonic acid    -   HPLC high performance liquid chromatography    -   LAH lithium aluminum hydride    -   LDA lithium diisopropylamide    -   LHMDS lithium bis(trimethylsilyl)amide    -   mCPBA meta-chloroperoxybenzoic acid    -   MeOH methanol    -   MHz megahertz    -   min minute or minutes    -   MS mass spectrometry    -   Ms methanesulfonyl    -   NMM N-methylmorpholine    -   NMR nuclear magnetic resonance    -   PCC pyridinium chlorochromate    -   RP reverse-phase    -   RT room temperature    -   R_(t) retention time    -   Sec second or seconds    -   TBDMS t-butyldimethylsilyl    -   TEA or Et₃N triethylamine    -   TFA trifluoroacetic acid    -   THF tetrahydrofuran    -   TIPS triisopropylsilyl    -   TLC thin layer chromatography    -   TMS tetramethylsilane

Scheme A illustrates a route for the synthesis of compounds of Formula(I)-A, -A1, and -A2 wherein Q, R¹, R², and R³ are as defined herein, andG is a functionalized ethyl group.

A compound of formula A1 is either commercially available or may beprepared by methods known in the scientific literature. A compound offormula A1 may be alkylated with an unsaturated alkyl bromide of formulaA2, in the presence of a base such as LHMDS, to afford a compound offormula A3. A compound of formula A3 may be undergo a reduction in thepresence of a hydride source such as DIBALH or LAH, or the like, toafford a compound of formula A4. Nucleophilic addition to aQ-substituted aldehyde of formula A5 affords the alcohol of formula A6.The alcohol of a compound of formula A6 may be oxidized to thecorresponding ketone of formula A7 by the action of an oxidizing agentsuch as Dess-Martin periodinane, PCC, Swern reagent, or the like.Reduction of the α/β-unsaturation may be achieved in the presence of ahydride source such as lithium tri-t-butoxide aluminum hydride or thelike, to afford a compound of formula A8. Cyclization with a hydrazineof formula A9 affords a pyrrolocyclopentyl ring of formula A10.Oxidation of the terminal alkenyl group of formula A10 in the presenceof osmium tetraoxide affords the corresponding aldehyde of formula A11.Reduction of the aldehyde by the action of a reducing agent such assodium borohydride or lithium aluminum hydride, or the like, affords acompound of formula (I)-A. The alcohol of formula (I)-A may be acylatedby various conventional methods known to one of skill in the art toafford a compound of formula (I)-A1. For example, a compound of formula(I)-A may be acylated with an acid chloride of formula A12 (whereinR^(A) is morpholin-4-yl or dimethylamino) to afford a compound offormula (I)-A1. A compound of formula A11 may also be treated witht-butylcarbamate in the presence of a hydride source such astriethylsilane or an acid such as TFA, to afford a carbamate of formula(I)-A2 of the present invention.

Scheme B illustrates a route for the synthesis of compounds of Formula(I)-B, -B1, and -B2, wherein Q, R¹, R², and R³ are as defined herein,and G is a functionalized methylene group.

A compound of formula B1 is either commercially available or may beprepared by methods known in the scientific literature. A compound offormula B1 may be treated under basic conditions with an acid chlorideof formula B2 to afford a compound of formula B3. Cyclization with ahydrazine of formula A9 affords pyrazolocyclopentyl ring of formula B4.Treatment with lithium amide affords the primary amide of formula (I)-B.Reduction of the amide in the presence of a hydride source such aslithium aluminum hydride or the like, affords a compound of formula B5,which subsequently may be treated with an alkylsulfonyl chloride, suchas methanesulfonyl chloride, to afford a compound of formula (I)-B1.Alternatively, a compound of formula (I)-B may be treated with cyanuricchloride to afford the corresponding cyanide of formula (I)-B2.

Scheme C illustrates a route for the synthesis of compounds of Formula(I)-C and -C1, wherein Q, R¹, R², and R³ are as defined herein, and G isan alcohol or carbamate.

A compound of formula C1 is either commercially available or may beprepared by methods known in the scientific literature. A compound offormula C1 may be treated with a base such as an organolithium base, inthe presence of a Lewis acid such as diethylaluminum chloride or borontrifluoride, followed by the addition of a compound of formula C2 toafford a compound of formula C3. The alcohol functional group may beprotected, wherein “P” is a conventional alcohol protecting group suchas TIPS, TBDMS, or benzyl, to afford a compound of formula C4. Treatmentwith hydroxide anion effected the saponification and removal of the TMSgroup to afford a compound of formula C5. A compound of formula C5 maybe brominated in the presence of N-bromosuccinimide and silver nitrateto afford a compound of formula C6. Compound C6 may be treated with NMMin the presence of isobutylchloroformate or other amide-type couplingreagent, such as EDCI, and a compound of formula A9 to afford a compoundof formula C7. The addition of carbon tetrachloride and polymer-boundtriphenylphosphine to a compound of formula C7 afforded the compound offormula C8, which may be heated in the presence of a tertiary aminebase, such as triethylamine or DIEA, to afford the cyclized product offormula C9. A compound of formula C9 may be cross-coupled with a boronicacid of formula C10 in the presence of the a transition metal catalyst,appropriate ligands, and in the presence of an inorganic base such assodium carbonate to afford a compound of formula (I)-C. Acylation with acompound of formula A11 affords compounds of formula (I)-C1 of thepresent invention.

Scheme D illustrates a route for the synthesis of compounds of Formula(I)-D, wherein Q, R¹, R², and R³ are as defined herein, and G is asulfonamide as defined herein.

A compound of formula (I)-C may be treated with methanesulfonyl chlorideto afford a compound of formula D1. Treatment with sodium azide effectsthe nucleophilic displacement to the mesylate to afford thecorresponding azide of formula D2. Azide reduction may be accomplishedby conventional catalytic hydrogenation or by treatment withtriphenylphosphine to afford the amine of formula D3. A compound offormula D3 may be acylated with an appropriately substituted sulfonylchloride (wherein R^(D) is methyl, isopropyl, or dimethylamino, forexample) to afford compounds of formula (I)-D of the present invention.

Scheme E illustrates a route for the synthesis of compounds of Formula(I)-E and -E1, wherein Q, R¹, R², and R³ are as defined herein, and G is1,2,3,4-tetrahydroquinolin-3-yl, an optionally substituted pyridinyl(wherein R^(E) is hydrogen, C₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl,morpholin-4-yl, or C₁₋₄alkoxycarbonyl), or C₃₋₆cycloalkyl as definedherein. For illustrative purposes only, Scheme E shows a cross-couplingwith an optionally substituted pyridinylboronic ester.

A compound of formula (I)-C may be oxidized by the action of anoxidizing agent such as Dess-Martin periodinane, PCC, Swern reagent, orthe like, to afford the corresponding ketone of formula (I)-E. Treatmentwith a base such as KHMDS, DBU, LDA, or the like, andN-phenyl-bis(trifluoromethanesulfonimide) or other triflating reagentaffords a compound of formula E1. A compound of formula E1 may becross-coupled with a boronic ester of formula E2 in the presence of apalladium catalyst, appropriate ligands, and an inorganic base, followedby conventional hydrogenation, to afford a compound of formula (I)-E1.

Scheme F illustrates a route for the synthesis of compounds of Formula(I)-F, wherein Q, R¹, R², and R³ are as defined herein, and G is aspirofused heterocyclyl as defined herein.

A compound of formula (I)-E may be treated with a compound of formula F1(wherein the carbon atoms of F1 are optionally substituted with one tofour methyl substituents) in the presence of a Lewis acid such as borontrifluoride-etherate to afford a ketal of formula (I)-F.

Scheme G illustrates a route for the synthesis of compounds of Formula(I)-F, wherein Q, R¹, R², and R³ are as defined herein, and G is ringG1, a cyclic amine such as morpholinyl or an optionally substitutedpiperidinyl or pyrrolidinyl ring.

A compound of formula (I)-E may be treated with a compound of formula G1(in the presence of a hydride source such as sodium cyanoborohydride,sodium triacetoxyborohydride, or the like, to afford an amine of formula(I)-G.

Scheme H illustrates a route for the synthesis of compounds of Formula(I)-H, wherein Q, R¹, R², and R³ are as defined herein, and G is analkyl substituent, R^(H), wherein R^(H) is an optionally substitutedC₁₋₆alkyl, C₃₋₆cycloalkyl(C₁₋₄alkyl, or C₃₋₆cycloalkyl.

A compound of formula (I)-E may be treated with an alkylmagnesiumbromide of formula H1 to form a compound of formula H2. A compound offormula H2 may undergo dehydration in the presence of the Burgessreagent (methyl N-triethylammoniumsulfonyl) carbamate) to afford acompound of formula H3. Reduction of the alkenyl functionality may beachieved by conventional palladium-catalyzed hydrogenation to afford acompound of formula (I)-H.

SPECIFIC EXAMPLES Example 1

A. To a solution of LHMDS (36.8 mL of a 1 M solution in THF, 36.8 mmol,1.1 eq) in THF (70 mL) at −78° C. under Ar was added a solution of3-ethoxy-2-cyclopentenone (1a) (4.0 mL, 33.45 mmol, 1 eq) in THF (40 mL)dropwise over 1 hr. After 20 min, a solution of allyl bromide (1b) (3.19mL, 36.8 mmol, 1.1 eq) in THF (40 mL) was added over 10 min. After 3 hrsat −78° C., water and NH₄Cl were added, the aqueous extracted withether, the organics combined, dried over MgSO₄ and concentrated.Purification by chromatography (80 g), eluting with 15 to 40%EA/hexanes, gave compound 1c (3.05 g, 55%). ¹H NMR (CHLOROFORM-d) δ:5.68-5.82 (m, J=16.9, 10.2, 6.8, 6.8 Hz, 1H), 5.25 (s, 1H), 5.01-5.12(m, 2H), 4.04 (q, J=7.1 Hz, 2H), 2.65-2.75 (m, 1H), 2.57 (qd, J=6.6, 4.0Hz, 2H), 2.28-2.39 (m, 1H), 2.11-2.23 (m, 1H), 1.41 (t, J=7.1 Hz, 3H).ESI-MS (m/z): Calcd. for C15H15ClO2: 167.1 (M+1). found: 167.1.

B. To a solution of compound 1c (3.05 g, 18.4 mmol, 1 eq) in THF (30 mL)at 0° C. was added diisobutylaluminum hydride (36.7 mL of a 1 M solutionin hexanes, 36.7 mmol, 2 eq) over 1 hr. After 1 hr, 1 N HCl was addeddropwise while at 0° C., then the reaction was warmed to rt over 2 hrs.The aqueous layer was extracted with ether, dried over MgSO₄ andconcentrated to give compound 1d (2.2 g crude). Purification of compound1d (1.0 g) by chromatography (40 g), eluting with 10 to 40% EA/hexanes,gave purified compound 1d (587 mg, 90%). ¹H NMR (CHLOROFORM-d) δ: 7.64(dd, J=5.7, 2.4 Hz, 1H), 6.18 (dd, J=5.7, 1.9 Hz, 1H), 5.69-5.86 (m,J=17.2, 9.9, 7.0, 7.0 Hz, 1H), 5.05-5.21 (m, 2H), 2.97-3.12 (m, 1H),2.52 (dd, J=18.8, 6.4 Hz, 1H), 2.16-2.38 (m, J=37.7, 14.1, 6.9, 6.9 Hz,2H), 2.00-2.12 (m, 1H).

C. To a solution of compound 1d (587 mg, 4.81 mmol, 1 eq) and4-chlorobenzaldehyde (le) (541 mg, 3.85 mmol, 0.8 eq) in methanol (25mL) at rt was added a solution of sodium carbonate (255 mg, 2.41 mmol,0.5 eq) in water (10 mL). After 1 hr, 1 N HCl was added, and themethanol was evaporated. The aqueous solution was extracted with DCM,and the organic phase was dried over MgSO₄, filtered, and concentrated.Purification by chromatography (60 g), eluting with 10 to 25%EA/hexanes, gave compound 1f (721 mg, 71%). ¹H NMR (CHLOROFORM-d) δ:7.28-7.36 (m, 4H), 7.13-7.21 (m, 1H), 5.65-5.79 (m, 1H), 5.53 (s, 1H),5.03-5.12 (m, 2H), 3.45 (br. s., 1H), 2.89-2.99 (m, 1H), 2.56-2.67 (m,1H), 2.28 (dt, J=13.6, 7.0 Hz, 1H), 2.10-2.23 (m, 2H). ESI-MS (m/z):Calcd. for C15H15ClO2: 245.1 (M−17). found: 245.0.

D. To a solution of compound 1f (1.18 g, 4.48 mmol, 1 eq) in DCM (40 mL)at 0° C. was added Dess-Martin periodinane (2.09 g, 4.93 mmol, 1.1 eq).After 1 hr, saturated NaHCO₃ and saturated sodium thiosulfate were addedand the mixture was stirred for 30 min. The reaction mixture wasextracted with DCM, dried over MgSO₄, filtered, and concentrated.Purification by chromatography (60 g), eluting with 15 to 25%EA/hexanes, gave compound 1g (660 mg, 57%). ¹H NMR (CHLOROFORM-d) δ:7.95 (d, J=2.5 Hz, 1H), 7.72-7.79 (m, 2H), 7.41-7.47 (m, 2H), 5.74-5.89(m, 1H), 5.12-5.22 (m, 2H), 3.14-3.23 (m, 1H), 2.78 (dd, J=19.2, 6.6 Hz,1H), 2.28-2.50 (m, 3H). ESI-MS (m/z): Calcd. for C15H13ClO2: 261.1(M+1). found: 261.0.

E. To a solution of compound 1g (660 mg, 2.53 mmol, 1 eq) in THF (20 mL)at 0° C. was added lithium tri-t-butoxide aluminum hydride (3.8 mL of a1 M solution in THF, 3.8 mmol, 1.5 eq). After 30 min, 1 N HCl was added,the solution was extracted with ethyl acetate, the organic phase wasdried over MgSO₄, filtered, and concentrated to give compound 1h, ˜80%pure (653 mg, 98%).

F. To a solution of compound 1h (415 mg, 1.58 mmol, 1 eq) in acetic acid(20 mL) at 80° C. was added 2-methoxyphenylhydrazine (1i) (252 mg, 1.82mmol, 1.15 eq). After 1 hr, the solution was cooled to rt andconcentrated. Purification by chromatography (40 g), eluting with 5 to30% EA/hexanes, gave compound 1j (2^(nd) major peak, 1^(st) peak wasundesired regioisomer, 227 mg, 39%). ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd,J=7.7, 1.6 Hz, 1H), 7.29-7.36 (m, 1H), 7.16-7.22 (m, 2H), 7.04-7.10 (m,2H), 7.01 (td, J=7.6, 1.0 Hz, 1H), 6.88 (d, J=8.3 Hz, 1H), 5.81-5.94 (m,J=17.1, 10.2, 6.8, 6.8 Hz, 1H), 5.01-5.15 (m, 2H), 3.49 (s, 3H),2.90-3.07 (m, 3H), 2.47-2.64 (m, 2H), 2.31-2.45 (m, 2H). ESI-MS (m/z):Calcd. for C22H21ClN2O: 365.1 (M+1). found: 365.3.

G. To a solution of compound 1j (116 mg, 0.32 mmol, 1 eq) in THF (7 mL)at 0° C. was added osmium tetraoxide (0.4 mL of a 2.5% solution int-butanol, 0.032 mmol, 0.1 eq) followed by a solution of sodiumperiodate (411 mg, 1.92 mmol, 6 eq) in water (5 mL). After 1 hr, asaturated solution of sodium thiosulfate was added and the mixture wasstirred for 30 min. The solution was then extracted with ether, theorganic phase was dried over MgSO₄, filtered, and concentrated to givecompound 1k. ¹H NMR (CHLOROFORM-d) δ: 9.86 (t, J=1.5 Hz, 1H), 7.31-7.40(m, 2H), 7.17-7.22 (m, 2H), 7.04-7.09 (m, 2H), 7.01 (td, J=7.6, 1.3 Hz,1H), 6.88 (dd, J=8.3, 1.3 Hz, 1H), 3.50 (s, 3H), 3.35-3.45 (m, 1H),3.06-3.18 (m, 2H), 2.81 (ddd, J=7.1, 5.3, 1.5 Hz, 2H), 2.46-2.62 (m,2H). ESI-MS (m/z): Calcd. for C21H19ClN2O2: 367.1 (M+1). found: 367.1.

H. To a solution of compound 1k in methanol (2 mL) was added sodiumborohydride (20 mg, 0.52 mmol, 1.7 eq). After 1 hr, water and NH₄Cl wereadded, the aqueous layer was extracted with ethyl acetate. The organicphase was dried over MgSO₄, filtered, and concentrated. Purification bychromatography (24 g), eluting with 40 to 100% EA/hexanes, gave compound1 (61 mg, 52%). ¹H NMR (CHLOROFORM-d/MeOH) δ: 7.33-7.41 (m, 2H),7.19-7.24 (m, 2H), 7.06-7.11 (m, 2H), 7.04 (td, J=7.7, 1.3 Hz, 1H),6.90-6.96 (m, 1H), 3.71 (t, J=6.8 Hz, 2H), 3.51 (s, 3H), 2.96-3.13 (m,3H), 2.55 (dd, J=15.2, 7.8 Hz, 2H), 1.91 (q, J=6.8 Hz, 2H). ESI-MS(m/z): Calcd. for C21H21ClN2O2: 369.1 (M+1). found: 369.1.

I. To a solution of compound 1 (17 mg, 0.045 mmol, 1 eq) in THF (2 mL)at rt was added NaHMDS (0.23 mL of 1 M solution in THF, 0.23 mmol, 5eq). After 30 min, 4-morpholinecarbonyl chloride (0.026 mL, 0.23 mmol, 5eq) was added and the solution was stirred overnight. The solution wasadded to a 5 mL diatomaceous earth extraction tube loaded with aqueousammonium chloride, and DCM was added, collected and concentrated.Purification by chromatography (8 g), eluting with 40 to 100%EA/hexanes, gave compound 2 (9.1 mg, 42%). ¹H NMR (CHLOROFORM-d) δ:7.31-7.40 (m, 2H), 7.17-7.22 (m, 2H), 7.04-7.09 (m, 2H), 7.01 (td,J=7.6, 1.3 Hz, 1H), 6.88 (dd, J=8.3, 1.0 Hz, 1H), 4.20-4.27 (m, 2H),3.66 (br. s., 5H), 3.44-3.51 (m, 7H), 2.94-3.09 (m, 3H), 2.56 (dd,J=16.4, 7.1 Hz, 2H), 1.96-2.04 (m, 2H). ESI-MS (m/z): Calcd. forC26H28ClN3O4: 482.2 (M+1). found: 482.2.

Following the procedure described above for Example 1 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compound was prepared:

Cpd 3: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.34 (td,J=7.9, 1.6 Hz, 1H), 7.17-7.22 (m, 2H), 7.05-7.09 (m, 2H), 7.01 (td,J=7.6, 1.3 Hz, 1H), 6.88 (dd, J=8.2, 1.1 Hz, 1H), 4.20 (t, J=6.6 Hz,2H), 3.49 (s, 3H), 2.96-3.09 (m, 3H), 2.92 (s, 6H), 2.49-2.64 (m, 2H),1.93-2.04 (m, 2H). ESI-MS (m/z): Calcd. for C24H26ClN3O3: 440.2 (M+1).found: 440.2.

Example 2

To a solution of compound 1k (23 mg, 0.06 mmol, 1 eq) in acetonitrile (2mL) was added t-butylcarbamate (37 mg, 0.31 mmol, 4.95 eq),triethylsilane (0.05 mL, 0.32 mmol, 5.1 eq) and trifluoroacetic acid(0.016 mL, 0.21 mmol, 3.3 eq). The solution was heated to 50° C.overnight in a vial. The solution was cooled, ethyl acetate added, andthe solution was washed sequentially with NaHCO₃ and brine. The organicphase was dried over MgSO₄, filtered, and concentrated. Purification bychromatography (8 g), eluting with 30 to 50% EA/hexanes, gave compound13 (19 mg, 65%). ¹H NMR (CHLOROFORM-d) δ: 7.36-7.41 (m, 1H), 7.34 (t,J=8.0 Hz, 1H), 7.19 (d, J=8.6 Hz, 2H), 7.06 (d, J=8.3 Hz, 2H), 7.01 (t,J=7.6 Hz, 1H), 6.88 (d, J=8.3 Hz, 1H), 4.58 (br. s., 1H), 3.49 (s, 3H),3.24 (d, J=6.1 Hz, 2H), 2.89-3.08 (m, 3H), 2.48-2.61 (m, 2H), 1.77-1.91(m, 2H), 1.46 (s, 9H). ESI-MS (m/z): Calcd. for C26H30ClN3O3: 468.2(M+1). found: 468.2.

Following the procedure described above for Example 2, substitutingacetamide for t-butylcarbamate, the following compound was prepared:

Cpd 12: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.40 (m, 2H), 7.17-7.24 (m, 2H),7.04-7.11 (m, 2H), 6.97-7.04 (m, 1H), 6.90 (d, J=7.6 Hz, 1H), 5.56 (br.s., 1H), 3.52 (s, 3H), 3.34-3.43 (m, 2H), 2.92-3.13 (m, 3H), 2.47-2.65(m, 2H), 2.02 (s, 3H), 1.6-1.8 (m, 2H). ESI-MS (m/z): Calcd. forC23H24ClN3O2: 410.2 (M+1). found: 410.2.

Example 3

A. A solution of compound 13 (13 mg, 0.03 mmol, 1 eq) in DCM (5 mL) andtrifluoroacetic acid (1 mL) was stirred for 2 hrs and concentrated. DCMwas added, the organics washed with NaHCO₃, dried over MgSO₄, filtered,and concentrated to give compound 3a (11 mg, 100%). ¹H NMR(CHLOROFORM-d) δ: 8.11 (br. s., 2H), 7.38 (t, J=7.8 Hz, 1H), 7.28 (d,J=7.6 Hz, 1H), 7.16-7.24 (m, J=8.3 Hz, 2H), 7.01-7.09 (m, J=8.3 Hz, 2H),6.98 (t, J=7.5 Hz, 1H), 6.90 (d, J=8.3 Hz, 1H), 3.52 (s, 3H), 2.83-3.21(m, 5H), 2.49 (br. s., 2H), 1.83-2.08 (m, 2H). Calcd. for C21H22ClN3O:368.2 (M+1). found: 368.2.

B. To a solution of compound 3a (10 mg, 0.027 mmol, 1 eq) in DCM (2 mL)was added triethylamine (0.019 mL, 0.14 mmol, 5 eq) and methanesulfonylchloride (0.01 mL, 0.14 mmol, 5 eq). After 1 hr, the solution wasconcentrated. Purification by chromatography (8 g), eluting with 50 to100% EA/hexanes, gave compound 11 (3 mg, 25%). ¹H NMR (CHLOROFORM-d) δ:7.30-7.41 (m, 2H), 7.17-7.23 (m, 2H), 7.04-7.10 (m, 2H), 6.97-7.04 (m,1H), 6.88 (d, J=8.3 Hz, 1H), 4.23-4.33 (m, 1H), 3.49 (s, 3H), 3.26 (q,J=6.7 Hz, 2H), 2.94-3.09 (m, 6H), 2.46-2.62 (m, 2H), 1.93 (q, J=6.7 Hz,2H). ESI-MS (m/z): Calcd. for C22H24ClN3O3S: 446.1 (M+1). found: 446.1.

Following the procedure described above for Example 3 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 20: ¹H NMR (CHLOROFORM-d) δ: 7.75-7.81 (m, 1H), 7.49-7.57 (m, 2H),7.16-7.25 (m, 3H), 6.97-7.03 (m, 2H), 4.58 (br. s., 1H), 3.24 (br. s.,2H), 2.90-3.08 (m, 3H), 2.55 (dd, J=14.7, 7.1 Hz, 2H), 1.84 (q, J=6.8Hz, 2H), 1.46 (s, 9H). ESI-MS (m/z): Calcd. for C26H27ClF3N3O2: 506.2(M+1). found: 506.2.

Cpd 22: ¹H NMR (CHLOROFORM-d) δ: 7.75-7.82 (m, 1H), 7.49-7.57 (m, 2H),7.15-7.25 (m, 3H), 6.96-7.03 (m, 2H), 4.42 (br. s., 1H), 3.31-3.41 (m,2H), 2.93-3.09 (m, 3H), 2.92 (s, 6H), 2.49-2.62 (m, 2H), 1.82-1.93 (m,2H). ESI-MS (m/z): Calcd. for C24H24ClF3N4O: 477.2 (M+1). found: 477.2.

Example 4

A. To a solution of LHMDS (15.8 mL of a 1 M solution in THF, 15.8 mmol,1.6 eq) in THF (15 mL) at −78° C. under Ar was added ethyl3-oxocyclopentanecarboxylate (4a) (1.55 g, 9.9 mmol, 1 eq) in THF (15mL) dropwise over 30 min. After 30 additional minutes, a solution of4-chlorobenzoyl chloride (4b) (1.25 mL, 9.9 mmol, 1 eq) in THF (10 mL)was added. After 1 hr, water and NH₄Cl were added and the reactionmixture was stirred overnight. The aqueous layer was extracted withether, the organics combined, dried over MgSO₄, filtered, andconcentrated. Purification by chromatography (80 g), eluting with 10 to40% EA/hexanes, gave compound 4c (83 mg, 3%). ¹H NMR (tautomeric mix,MeOH-d4) δ: 7.67-7.74 (m, 2H), 7.43-7.52 (m, 2H), 4.15-4.28 (m, 2H),3.06-3.24 (m, 3H), 2.48-2.94 (m, 2H), 1.25-1.35 (m, 3H). Calcd. forC15H15ClO4: 295.1 (M+1). found: 294.9.

B. To a solution of compound 4c (83 mg, 0.28 mmol, 1 eq) in acetic acid(3 mL) at 80° C. was added 2-methoxyphenylhydrazine free base (11) (43mg, 0.31 mmol, 1.1 eq). After 30 min, the solution was concentrated.Purification by chromatography (8 g), eluting with 10 to 25% EA/hexanes,gave compound 5 (62 mg, 56%). ¹H NMR (CHLOROFORM-d) δ: 7.31-7.40 (m,2H), 7.17-7.23 (m, 2H), 7.05-7.10 (m, 2H), 7.01 (td, J=7.7, 1.3 Hz, 1H),6.88 (dd, J=8.3, 1.0 Hz, 1H), 4.22 (q, J=7.1 Hz, 2H), 3.72-3.82 (m, 1H),3.50 (s, 3H), 3.07-3.22 (m, 4H), 1.31 (t, J=7.2 Hz, 3H). ESI-MS (m/z):Calcd. for C22H21ClN2O3: 397.1 (M+1). found: 397.1.

C. To lithium amide (45 mg, 1.95 mmol, 13 eq) in a vial was added asolution of compound 5 (60 mg, 0.15 mmol, 1 eq) in THF (2 mL) and thesuspension was heated to 65° C. overnight. Methanol, water and 1 N HClwere added and the reaction mixture was extracted with ethyl acetate.The organics were combined, dried over MgSO₄, filtered, andconcentrated. Purification by chromatography (8 g), eluting with 2 to 5%methanol/DCM, gave compound 6 (23 mg, 42%). ¹H NMR (CHLOROFORM-d) δ:7.31-7.40 (m, 2H), 7.17-7.23 (m, 2H), 7.04-7.09 (m, 2H), 7.01 (td,J=7.7, 1.3 Hz, 1H), 6.88 (dd, J=8.3, 1.0 Hz, 1H), 5.66 (br. s., 2H),3.61-3.74 (m, 1H), 3.50 (s, 3H), 3.02-3.23 (m, 4H). ESI-MS (m/z): Calcd.for C20H18ClN3O2: 368.1 (M+1). found: 368.1.

D. To a solution of compound 6 (22 mg, 0.06 mmol, 1 eq) in THF at rt wasadded LAH (0.18 mL of a 1 M solution in THF, 0.18 mmol, 3 eq). After 1hr, additional LAH (0.18 mL) was added. After 3 hrs, added saturatedsodium potassium tartrate, stirred 30 min, and added water. The reactionmixture was extracted with ether, dried over MgSO₄, filtered, andconcentrated. Purification by chromatography (8 g), eluting with 2 to10% methanol/DCM and NH₃ (1%) gave compound 4d as a mixture of thedesired product and loss of Cl (5 mg, 24%).

E. To a solution of compound 4d (5 mg, 0.014 mmol, 1 eq) in DCM (2 mL)was added triethylamine (0.01 mL, 0.07 mmol, 5 eq) and methanesulfonylchloride (0.006 mL, 0.07 mmol, 5 eq). After stirring overnight, thesolution was concentrated. Purification by HPLC, eluting with 20 to 80to 100% acetonitrile/water, gave compound 8 (1 mg, 17%). ¹H NMR(CHLOROFORM-d) δ: 7.40 (dd, J=15.9, 1.8 Hz, 1H), 7.32 (dd, J=7.8, 1.5Hz, 1H), 7.21-7.25 (m, 2H), 7.05-7.10 (m, 2H), 7.01 (td, J=7.6, 1.1 Hz,1H), 6.89-6.94 (m, 1H), 4.46 (br. s., 1H), 3.55 (s, 3H), 3.32-3.40 (m,2H), 3.02-3.26 (m, 2H), 3.01 (s, 3H), 2.71 (ddd, J=15.4, 9.6, 5.6 Hz,2H). ESI-MS (m/z): Calcd. for C21H22ClN3O3S: 432.1 (M+1). found: 432.1.

F. To a solution of compound 6 (7 mg, 0.02 mmol, 1 eq) in DMF (2 mL) wasadded cyanuric chloride (11 mg, 0.06 mmol, 3 eq). After 1 hr, addedwater was added and the reaction mixture was extracted with DCM. Theorganic phase was dried over MgSO₄, filtered, and concentrated.Purification by HPLC, eluting with 20 to 80 to 100% acetonitrile/water,gave compound 10 (2 mg, 29%). ¹H NMR (CHLOROFORM-d) δ: 7.36-7.42 (m,1H), 7.34 (dd, J=7.7, 1.6 Hz, 1H), 7.21-7.26 (m, 2H), 6.99-7.08 (m, 3H),6.91 (dd, J=8.3, 1.0 Hz, 1H), 3.75 (quin, J=7.9 Hz, 1H), 3.54 (s, 3H),3.34-3.43 (m, 1H), 3.15-3.34 (m, 3H). ESI-MS (m/z): Calcd. forC20H16ClN3O: 350.1 (M+1). found: 350.1.

Following the procedure described above for Example 4 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 14: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.39 (m, 1H), 7.30 (d, J=6.8 Hz,1H), 7.15-7.25 (m, 4H), 6.99-7.04 (m, 2H), 4.23 (q, J=7.2 Hz, 2H), 3.79(quin, J=8.4 Hz, 1H), 3.11-3.25 (m, 4H), 2.36 (q, J=7.7 Hz, 2H), 1.32(t, J=7.1 Hz, 3H), 1.00 (t, J=7.6 Hz, 3H). ESI-MS (m/z): Calcd. forC23H23ClN2O2: 395.2 (M+1). found: 395.2.

Cpd 16: ¹H NMR (CHLOROFORM-d) δ: 7.50-7.88 (m, 1H), 7.39-7.48 (m, 1H),7.27-7.36 (m, 3H), 7.18-7.25 (m, 2H), 7.00-7.07 (m, 2H), 2.96-3.46 (m,5H), 2.56-2.78 (m, 2H), 2.27 (br. s., 2H), 1.38-1.55 (m, 9H), 0.98 (t,J=7.6 Hz, 3H). ESI-MS (m/z): Calcd. for C26H30ClN3O2: 452.2 (M+1).found: 452.2.

Cpd 17: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.39 (m, 1H), 7.30 (d, J=6.6 Hz,1H), 7.15-7.25 (m, 4H), 6.98-7.04 (m, 2H), 4.17-4.29 (m, 2H), 3.15-3.39(m, 5H), 3.02 (ddd, J=15.7, 8.5, 2.1 Hz, 2H), 2.69 (ddd, J=15.6, 13.8,6.2 Hz, 2H), 2.36 (q, J=7.6 Hz, 2H), 1.12 (br. s., 6H), 1.00 (t, J=7.6Hz, 3H). ESI-MS (m/z): Calcd. for C26H30ClN3O2: 452.2 (M+1). found:452.2.

Cpd 18: ¹H NMR (CHLOROFORM-d) δ: 7.36 (td, J=7.3, 1.8 Hz, 1H), 7.30 (d,J=6.6 Hz, 1H), 7.16-7.25 (m, 4H), 6.97-7.04 (m, 2H), 4.49 (t, J=6.3 Hz,1H), 3.36 (t, J=6.7 Hz, 2H), 3.12-3.24 (m, 1H), 3.02-3.11 (m, 2H), 3.00(s, 3H), 2.65 (ddd, J=22.4, 15.8, 6.1 Hz, 2H), 2.35 (q, J=7.6 Hz, 2H),1.00 (t, J=7.6 Hz, 3H). ESI-MS (m/z): Calcd. for C22H24ClN3O2S: 430.1(M+1). found: 430.1.

Cpd 19: ¹H NMR (CHLOROFORM-d) δ: 7.33-7.40 (m, 1H), 7.28-7.33 (m, 1H),7.14-7.25 (m, 4H), 6.96-7.04 (m, 2H), 6.69 (br. s., 1H), 3.57 (tq,J=13.1, 6.7 Hz, 2H), 3.14-3.26 (m, 1H), 3.05 (ddd, J=15.5, 8.1, 2.9 Hz,2H), 2.61 (ddd, J=15.3, 9.2, 5.8 Hz, 2H), 2.35 (q, J=7.6 Hz, 2H), 1.00(t, J=7.6 Hz, 3H). ESI-MS (m/z): Calcd. for C23H21ClF3N3O: 448.1 (M+1).found: 448.1.

Example 5

A. To a solution of trimethylsilyl acetylene (5a) (1.41 mL, 10.14 mmol,1.1 eq) in toluene (24 mL) at −45° C. under Ar was added n-BuLi (4.06 mLof a 2.5 M solution in hexanes, 10.14 mmol, 1.1 eq). A suspensionformed, and after 10 min, the mixture was warmed to 0° C. After 10 min,diethylaluminum chloride (10.14 mL of a 1 M solution in hexanes, 10.14mmol, 1.1 eq) was added. After 1 hr, (R)-ethyloxiranyl acetate (5b) (1.0mL, 9.22 mmol, 1 eq) in toluene (10 mL) was added and the mixturestirred at 0° C. for 1 hr. To the suspension at 0° C. was added dropwise3 mL saturated NH₄Cl, followed by the dropwise addition of 4 mL 1 N HClto precipitate the aluminum salts. After stirring overnight, thesuspension was filtered through diatomaceous earth, with ethyl acetatewashings. The filtrate was washed with brine, dried over MgSO₄,filtered, and concentrated. Purification by column chromatography (40g), eluting with 10 to 20% EA/hexanes, gave compound 5c (1.28 g, 61%).¹H NMR (CHLOROFORM-d) δ: 4.11-4.24 (m, 3H), 3.03 (d, J=4.5 Hz, 1H),2.63-2.72 (m, 1H), 2.41-2.59 (m, 3H), 1.29 (t, J=7.2 Hz, 3H), 0.16 (s,9H).

B. To a solution of compound 5c (1.28 g, 5.58 mmol, 1 eq) in DCM (20 mL)at 0° C. was added diisopropylethylamine (1.36 mL, 7.82 mmol, 1.4 eq)followed by triisopropylsilyl trifluoromethanesulfonate (1.81 mL, 6.7mmol, 1.2 eq). Upon addition of water, the reaction mixture wasextracted with DCM, dried over MgSO₄, filtered, and concentrated tocompound 5d. To a solution of compound 5d in ethanol (20 mL) was added 1N NaOH (10 mL) and the reaction heated to 50° C. overnight, followed byadditional heating at 80° C. for 4 hr. The reaction mixture was madeacidic by the addition of 1N HCl. The ethanol was removed, the aqueousmixture was extracted with DCM, the organics combined, dried over MgSO₄,filtered, and concentrated. Purification by column chromatography (80g), eluting with 0 to 40% EA/hexanes, gave compound 5e (1.51 g, 95%). ¹HNMR (CHLOROFORM-d) δ: 4.37-4.45 (m, 1H), 2.83 (dd, J=15.4, 5.3 Hz, 1H),2.68 (dd, J=15.5, 5.9 Hz, 1H), 2.51-2.56 (m, 2H), 2.03-2.05 (m, 1H),1.03-1.10 (m, 21H).

C. To a solution of compound 5e (1100 mg, 3.87 mmol, 1 eq) in acetone(20 mL) at rt was added silver nitrate (66 mg, 0.39 mmol, 0.1 eq)followed by N-bromosuccinimide (757 mg, 4.25 mmol, 1.1 eq). After 3 hrs,water and 1N HCl were sequentially added to the solution. The resultantprecipitate was dissolved in DCM, washed with water, and the organicphase was dried, filtered, and concentrated to compound 5f (1.53 g, ˜90%pure, 98% yield). ¹H NMR (CHLOROFORM-d) δ: 4.39 (t, J=5.9 Hz, 1H),2.59-2.84 (m, 3H), 2.54 (d, J=6.1 Hz, 1H), 0.96-1.15 (m, 21H).

D. To a solution of compound 5f (1.53 g, 3.79 mmol, 1 eq) in DCM (20 mL)at rt under Ar was added N-methylmorpholine (0.44 mL, 3.98 mmol, 1.05eq) followed by isobutylchloroformate (0.52 mL, 3.98 mmol, 1.05 eq).After 20 min, a solution of compound 1i-HCl (794 mg, 4.55 mmol, 1.2 eq)and N-methylmorpholine (0.50 mL, 4.55 mmol, 1.2 eq) in DCM (10 mL) wasadded and the solution stirred for 60 min. Water and 1 N HCl weresequentially added, the reaction mixture was extracted with DCM, theorganics combined, washed with NaHCO₃ and brine, dried over MgSO₄,filtered, and concentrated. Purification by column chromatography (80g), eluting with 10 to 20 to 25% EA/hexanes, gave compound 5g (1.42 g,78%). ESI-MS (m/z): Calcd. for C22H35BrN2O3Si: 483.2 (M+1). found:483.0.

E. In a 1-L 3-neck round bottom flask equipped with an overhead stirrer,heating mantel, septa, and temperature probe was added(S)-6-bromo-N′-(2-methoxyphenyl)-3-(triisopropylsilyloxy)hexanes-5-ynehydrazide(5g) (26.27 g, 54.3 mmol, 1 eq), acetonitrile (550 mL) and carbontetrachloride (21.0 mL, 217 mmol, 4 eq). One portion of polymer-boundtriphenylphosphine (3 mmol/g P, 73.6 g, 221 mmol, 4 eq) was added atroom temperature and the suspension was stirred for 1 h. The color ofthe polymer remained brown (unchanged) and no reaction was detected byTLC (30% EtOAc in heptane). The reaction was heated to 50° C. for 30min, then the reaction was allowed to cool to room temperature for 1 h,filtered through silica gel (150 g) and washed with acetonitrile (600mL), whereby a whitish substance came through the filter pad. Afterfiltration and evaporation there was collected an orange oil that wasstill cloudy; EtOAc (100 mL) was added, dried with Na₂SO₄, filtered andevaporated to provide compound 5h (21 g) as an orange oil in 75% yield.The crude product was carried on to the next reaction without furtherpurification. ¹H NMR (CHLOROFORM-d) δ: 8.07 (s, 1H), 7.32 (d, J=7.6 Hz,1H), 6.92 (dt, J=8.2, 4.2 Hz, 1H), 6.84 (d, J=3.7 Hz, 2H), 4.39 (quin,J=5.8 Hz, 1H), 3.89 (s, 3H), 2.85-3.00 (m, 2H), 2.46-2.60 (m, 2H),1.01-1.12 (m, 21H). ESI-MS (m/z): Calcd. for C22H34BrClN2O2Si: 464.1(M-36). found: 464.3.

F. Compound 5h (385 mg, 0.77 mmol, 1 eq) and triethylamine (0.43 mL,3.07 mmol, 4 eq) in dioxane (10 mL) were heated at 90° C. for 20 hrs.Water was added to the reaction mixture, and the mixture was extractedwith DCM, dried over MgSO₄, filtered, and concentrated. Purification bycolumn chromatography (40 g), eluting with 5 to 10% EA/hexanes, gavecompound 5i (300 mg, 65%). ¹H NMR (CHLOROFORM-d) δ: 7.42 (td, J=8.0, 1.8Hz, 1H), 7.28-7.34 (m, 1H), 6.99-7.06 (m, 2H), 5.05 (t, J=6.2 Hz, 1H),3.82 (s, 3H), 3.18 (dd, J=15.7, 7.3 Hz, 1H), 3.04 (dd, J=15.0, 7.2 Hz,1H), 2.83 (dd, J=15.8, 6.2 Hz, 1H), 2.66 (dd, J=15.0, 5.9 Hz, 1H),1.05-1.18 (m, 21H). ESI-MS (m/z): Calcd. for C22H33BrN2O2Si: 465.2(M+1). found: 465.2.

F. To a solution of compound 5i (197 mg, 0.42 mmol, 1 eq) in dioxane (5mL) was added 1 N HCl (1 mL), and the reaction was heated to 80° C. for3 hrs. The solution was extracted with DCM, dried over MgSO₄, filtered,and concentrated to give compound 5j (124 mg, 95%). ¹H NMR(CHLOROFORM-d) δ: 7.43 (t, J=7.9 Hz, 1H), 7.32 (d, J=7.3 Hz, 1H),7.00-7.08 (m, 2H), 4.94-5.04 (m, 1H), 3.83 (s, 3H), 3.21 (dd, J=16.3,6.5 Hz, 1H), 3.08 (dd, J=15.6, 6.4 Hz, 1H), 2.82 (dd, J=16.4, 3.9 Hz,1H), 2.66 (dd, J=15.7, 3.7 Hz, 1H), 1.97 (d, J=6.1 Hz, 1H). ESI-MS(m/z): Calcd. for C13H13BrN2O2: 309.2 (M+1). found: 309.0.

G. To a solution of 4-chlorophenylboronic acid (5k) (76 mg, 0.49 mmol,1.5 eq) in dimethoxyethane (1 mL) was added 2 M Na₂CO₃ (0.1 mL),compound 5j (100 mg, 0.32 mmol, 1 eq), and (Ph₃P)₄Pd (19 mg, 0.016 mmol,0.05 eq). The solution was degassed by bubbling Argon through thesolution, then heated to 85° C. for 3 days. Water and brine were addedto the reaction mixture which was then extracted with ethyl acetate. Thecombined organic phases were dried over MgSO₄, filtered, andconcentrated. Purification by column chromatography (12 g), eluting with50 to 100% EA/hexanes, gave compound 5l (80 mg, 71%). ¹H NMR(CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.31-7.37 (m, 1H),7.17-7.25 (m, J=8.3 Hz, 2H), 7.05-7.11 (m, J=8.3 Hz, 2H), 7.02 (td,J=7.6, 1.1 Hz, 1H), 6.88 (d, J=8.1 Hz, 1H), 4.97-5.11 (m, 1H), 3.49 (s,3H), 3.14-3.29 (m, 2H), 2.70-2.90 (m, 2H), 2.08 (d, J=5.3 Hz, 1H).ESI-MS (m/z): Calcd. for C19H17ClN2O2: 341.1 (M+1). found: 341.2.

Example 6

A. Compound 25 was prepared according to the procedures described inExample 5, substituting (2-(trifluoromethoxy)phenyl)hydrazine forcompound 1i in Step D.

B. To a solution of compound 25 (22 mg, 0.056 mmol, 1 eq) in THF (1.5mL) was added NaHMDS (0.28 mL of a 1 M solution in THF, 0.28 mmol, 5 eq)followed by dimethylcarbamoyl chloride (0.026 mL, 0.28 mmol, 5 eq).After 2 hrs, saturated NH₄Cl was added and the solution was poured ontoa 5 mL extraction tube filled with diatomaceous earth, washed throughwith DCM, dried, filtered, and concentrated. Purification bychromatography (8 g), eluting with 20 to 40% EA/hexanes, gave compound23 (14.9 mg, 57%). ¹H NMR (CHLOROFORM-d) δ: 7.52-7.58 (m, 1H), 7.33-7.46(m, 2H), 7.19-7.28 (m, 3H), 7.01-7.08 (m, 2H), 5.77 (tt, J=7.2, 3.6 Hz,1H), 3.25-3.37 (m, 2H), 2.83-3.01 (m, 8H). ESI-MS (m/z): Calcd. forC22H19ClF3N3O3: 466.1 (M+1). found: 466.1.

Following the procedure described above for Example 6 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 24: ¹H NMR (CHLOROFORM-d) δ: 7.55 (dd, J=7.5, 1.9 Hz, 1H), 7.34-7.46(m, 2H), 7.20-7.29 (m, 3H), 7.00-7.07 (m, 2H), 5.80 (tt, J=7.0, 3.7 Hz,1H), 3.40-3.76 (m, 8H), 3.33 (dd, J=16.7, 7.1 Hz, 2H), 2.84-3.00 (m,2H). ESI-MS (m/z): Calcd. for C24H21ClF3N3O4: 508.1 (M+1). found: 508.1.

Cpd 28: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.35 (td,J=8.0, 1.8 Hz, 1H), 7.17-7.22 (m, 2H), 7.05-7.10 (m, 2H), 7.02 (td,J=7.6, 1.3 Hz, 1H), 6.89 (dd, J=8.3, 1.0 Hz, 1H), 5.73-5.80 (m, 1H),3.50 (s, 3H), 3.29-3.39 (m, 2H), 2.84-3.00 (m, 8H). ESI-MS (m/z): Calcd.for C22H22ClN3O3: 412.1 (M+1). found: 412.1.

Cpd 29: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.42 (m, 2H), 7.17-7.23 (m, 2H),7.05-7.10 (m, 2H), 7.02 (td, J=7.7, 1.3 Hz, 1H), 6.90 (dd, J=8.3, 1.0Hz, 1H), 5.80 (dt, J=7.3, 3.6 Hz, 1H), 3.66 (br. s., 4H), 3.50 (s, 7H),3.29-3.40 (m, 2H), 2.85-3.01 (m, 2H). ESI-MS (m/z): Calcd. forC24H24ClN3O4: 454.2 (M+1). found: 454.2.

Cpd 30: ¹H NMR (CHLOROFORM-d) δ: 7.49 (dd, J=7.8, 1.8 Hz, 1H), 7.32 (td,J=8.0, 1.8 Hz, 1H), 7.16-7.23 (m, 2H), 7.06-7.13 (m, 2H), 7.04 (td,J=7.6, 1.1 Hz, 1H), 6.80-6.86 (m, 1H), 5.72-5.81 (m, 1H), 3.71 (br. s.,2H), 3.33 (dd, J=16.5, 7.2 Hz, 2H), 2.80-3.02 (m, 8H), 0.98 (t, J=6.9Hz, 3H). ESI-MS (m/z): Calcd. for C23H24ClN3O3: 426.2 (M+1). found:426.2.

Cpd 31: ¹H NMR (CHLOROFORM-d) δ: 7.49 (dd, J=7.8, 1.5 Hz, 1H), 7.33 (td,J=7.9, 1.6 Hz, 1H), 7.16-7.23 (m, 2H), 7.06-7.11 (m, 2H), 7.04 (td,J=7.6, 1.1 Hz, 1H), 6.80-6.87 (m, 1H), 5.80 (tt, J=7.1, 3.8 Hz, 1H),3.57-3.91 (m, 6H), 3.49 (br. s., 4H), 3.27-3.42 (m, 2H), 2.81-3.02 (m,2H), 0.98 (t, J=7.1 Hz, 3H). ESI-MS (m/z): Calcd. for C25H26ClN3O4:468.2 (M+1). found: 468.2.

Example 7

A. Compound 26 was prepared according to the procedures described inExample 5, substituting the appropriate racemic starting materials.

B. To compound 26 (200 mg, 0.53 mmol, 1 eq) in DCM (5 mL) at rt wasadded triethylamine (0.15 mL, 1.06 mmol, 2 eq) followed bymethanesulfonyl chloride (0.062 mL, 0.79 mmol, 1.5 eq). After stirringfor 2 hrs, DCM was added. The organic phase was washed with water, driedover MgSO₄, filtered, and concentrated. Purification by columnchromatography (24 g), eluting with 30 to 60% EA/hexanes, gave compound7a (230 mg, 99%). ¹H NMR (CHLOROFORM-d) δ: 7.32-7.41 (m, 2H), 7.19-7.24(m, 2H), 6.99-7.09 (m, 3H), 6.89 (d, J=8.3 Hz, 1H), 5.73-5.83 (m, 1H),3.50 (s, 3H), 3.38 (ddd, J=16.5, 6.8, 3.8 Hz, 2H), 3.15 (dt, J=16.5, 4.4Hz, 2H), 3.08 (s, 3H). ESI-MS (m/z): Calcd. for C20H19ClN2O4S: 419.1(M+1). found: 419.1.

C. To compound 7a (220 mg, 0.53 mmol, 1 eq) in DMF (5 mL) at rt wasadded sodium azide (52 mg, 0.79 mmol, 1.5 eq) and the solution waswarmed to 100° C. After 1 hr the reaction was cooled, water was added,and the aqueous phase was extracted with DCM. The combined organicphases were dried over MgSO₄, filtered, and concentrated to compound 7b(184 mg, 95%). ¹H NMR (CHLOROFORM-d) δ: 7.31-7.42 (m, 2H), 7.22 (d,J=8.6 Hz, 2H), 6.99-7.10 (m, 3H), 6.88 (d, J=7.8 Hz, 1H), 4.61-4.73 (m,1H), 3.50 (s, 3H), 3.16-3.30 (m, 2H), 2.83-2.98 (m, 2H). ESI-MS (m/z):Calcd. for C19H16ClN5O: 366.1 (M+1). found: 366.1.

D. To a solution of compound 7b (184 mg, 0.50 mmol) in ethyl acetate (10mL) and ethanol (5 mL) was added 10% Pd/C (50 mg), under a hydrogen gasatmosphere. After 16 hrs, the suspension was filtered throughdiatomaceous earth, washed with EA, dried and concentrated to compound7c (164 mg, 96%). ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.8, 1.8 Hz, 1H),7.31-7.37 (m, 1H), 7.17-7.23 (m, 2H), 7.05-7.10 (m, 2H), 6.97-7.04 (m,1H), 6.88 (d, J=8.3 Hz, 1H), 4.23 (quin, J=6.4 Hz, 1H), 3.49 (s, 3H),3.19 (td, J=15.9, 7.1 Hz, 2H), 2.51-2.67 (m, 2H). ESI-MS (m/z): Calcd.for C19H18ClN3O: 340.1 (M+1). found: 340.1.

E. To a solution of compound 7c (29 mg, 0.084 mmol, 1 eq) in DCM (1 mL)was added triethylamine (0.035 mL, 0.25 mmol, 3 eq) and methanesulfonylchloride (0.013 mL, 0.17 mmol, 2 eq). After 2 hrs, saturated NaHCO₃ wasadded, the reaction mixture was poured onto a 5 mL extraction tubefilled with diatomaceous earth, washed through with DCM, andconcentrated. Purification by chromatography (8 g), eluting with 40 to100% EA/hexanes, gave compound 32 (33 mg, 94%). ¹H NMR (CHLOROFORM-d) δ:7.32-7.40 (m, 2H), 7.18-7.24 (m, 2H), 6.98-7.08 (m, 3H), 6.88 (d, J=8.3Hz, 1H), 5.04 (d, J=9.1 Hz, 1H), 4.59-4.72 (m, 1H), 3.50 (s, 3H),3.27-3.39 (m, 2H), 3.04 (s, 3H), 2.74-2.87 (m, 2H). ESI-MS (m/z): Calcd.for C20H20C1N3O3S: 418.1 (M+1). found: 418.1.

Following the procedure described above for Example 7 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 33: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.40 (m, 2H), 7.18-7.24 (m, 2H),6.99-7.08 (m, 3H), 6.89 (d, J=8.3 Hz, 1H), 4.58-4.70 (m, 1H), 4.52 (d,J=9.9 Hz, 1H), 3.50 (s, 3H), 3.28-3.39 (m, 2H), 3.22 (quin, J=6.9 Hz,1H), 2.76-2.86 (m, 2H), 1.42 (dd, J=6.8, 1.3 Hz, 6H). ESI-MS (m/z):Calcd. for C22H24ClN3O3S: 446.1 (M+1). found: 446.1.

Cpd 34: ¹H NMR (CHLOROFORM-d) δ: 7.31-7.39 (m, 2H), 7.18-7.24 (m, 2H),6.99-7.08 (m, 3H), 6.88 (d, J=8.3 Hz, 1H), 4.81 (d, J=9.3 Hz, 1H),4.48-4.61 (m, 1H), 3.49 (s, 3H), 3.30 (dd, J=15.9, 7.8 Hz, 2H),2.75-2.87 (m, 8H). ESI-MS (m/z): Calcd. for C21H23ClN4O3S: 447.1 (M+1).found: 447.1.

Cpd 44: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.23-7.29(m, 1H), 7.11-7.16 (m, 2H), 6.93-7.03 (m, 3H), 6.77 (d, J=7.3 Hz, 1H),4.50-4.64 (m, 1H), 4.39 (d, J=9.3 Hz, 1H), 3.64 (br. s., 2H), 3.27 (dd,J=15.9, 7.8 Hz, 2H), 3.15 (quin, J=6.8 Hz, 1H), 2.66-2.82 (m, 2H), 1.36(dd, J=6.8, 1.3 Hz, 6H), 0.92 (t, J=6.9 Hz, 3H). ESI-MS (m/z): Calcd.for C23H26ClN3O3S: 460.1 (M+1). found: 460.1.

Cpd 45: ¹H NMR (CHLOROFORM-d) δ: 7.41 (dd, J=7.7, 1.6 Hz, 1H), 7.24-7.31(m, 1H), 7.12-7.17 (m, 2H), 6.94-7.03 (m, 3H), 6.78 (d, J=7.6 Hz, 1H),6.61 (br. s., 1H), 5.07 (d, J=7.6 Hz, 1H), 3.66 (br. s., 2H), 3.23-3.43(m, 2H), 2.65-2.80 (m, 2H), 0.92 (t, J=7.1 Hz, 3H). ESI-MS (m/z): Calcd.for C22H19ClF3N3O2: 450.1 (M+1). found: 450.1.

Cpd 47: ¹H NMR (CHLOROFORM-d) δ: 7.46 (dd, J=7.7, 1.6 Hz, 1H), 7.33 (td,J=7.8, 1.8 Hz, 1H), 7.18-7.23 (m, 2H), 7.00-7.10 (m, 3H), 6.84 (dd,J=8.3, 1.0 Hz, 1H), 4.53 (br. s., 2H), 3.55-3.88 (m, 2H), 3.26-3.38 (m,2H), 2.76-2.88 (m, 8H), 0.99 (t, J=6.9 Hz, 3H). ESI-MS (m/z): Calcd. forC22H25ClN4O3S: 461.1 (M+1). found: 461.1.

Example 8

To a solution of compound 32 (21 mg, 0.05 mmol, 1 eq) in THF (2 mL) wasadded NaHMDS (0.3 mL of a 1 M solution in THF, 0.3 mmol, 6 eq) followedby iodomethane (0.019 mL, 0.3 mmol, 6 eq). After stirring overnight,NH₄Cl was added, the solution was poured onto a 5 mL extraction tubefilled with diatomaceous earth, washed through with DCM, andconcentrated. Purification by chromatography (8 g), eluting with 35 to70% EA/hexanes, gave compound 37 (8.2 mg, 38%). ¹H NMR (CHLOROFORM-d) δ:7.31-7.42 (m, 2H), 7.19-7.24 (m, 2H), 6.99-7.10 (m, 3H), 6.89 (d, J=8.3Hz, 1H), 5.21-5.31 (m, 1H), 3.50 (s, 3H), 3.15 (dd, J=16.0, 8.7 Hz, 2H),2.84-3.02 (m, 8H). ESI-MS (m/z): Calcd. for C21H22ClN3O3S: 432.1 (M+1).found: 432.1.

Following the procedure described above for Example 8 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 46: ¹H NMR (CHLOROFORM-d) δ: 7.48 (dd, J=7.8, 1.5 Hz, 1H), 7.30-7.37(m, 1H), 7.17-7.24 (m, 2H), 7.07-7.12 (m, J=8.6 Hz, 2H), 7.04 (td,J=7.6, 1.0 Hz, 1H), 6.84 (d, J=7.6 Hz, 1H), 5.13 (br. s., 1H), 3.71 (br.s., 2H), 3.07-3.22 (m, 2H), 2.90-3.04 (m, 2H), 2.84 (s, 9H), 0.99 (t,J=6.9 Hz, 3H). ESI-MS (m/z): Calcd. for C23H27ClN4O3S: 475.2 (M+1).found: 475.2.

Cpd 48: ¹H NMR (CHLOROFORM-d) δ: 7.47 (dd, J=7.7, 1.6 Hz, 1H), 7.29-7.36(m, 1H), 7.18-7.24 (m, 2H), 7.06-7.11 (m, 2H), 7.04 (td, J=7.7, 1.3 Hz,1H), 6.83 (dd, J=8.3, 1.0 Hz, 1H), 5.06-5.18 (m, 1H), 3.70 (br. s., 2H),3.08-3.21 (m, 2H), 2.90-3.03 (m, 2H), 2.84 (s, 9H), 0.99 (t, J=6.9 Hz,3H). ESI-MS (m/z): Calcd. for C23H27ClN4O3S: 475.2 (M+1). found: 475.2.

Cpd 50: ¹H NMR (CHLOROFORM-d) δ: 7.21-7.26 (m, 2H), 7.18 (dd, J=7.3, 1.0Hz, 1H), 7.09-7.15 (m, 2H), 6.99-7.05 (m, 1H), 6.81-6.87 (m, 1H),5.05-5.16 (m, 1H), 4.43 (t, J=8.7 Hz, 2H), 3.21 (t, J=8.7 Hz, 2H), 3.13(ddd, J=15.9, 11.2, 8.5 Hz, 2H), 2.89-3.01 (m, 2H), 2.80-2.85 (m, 9H).ESI-MS (m/z): Calcd. for C23H25ClN4O3S: 473.1 (M+1). found: 473.1.

Cpd 51: ¹H NMR (CHLOROFORM-d) δ: 7.22-7.26 (m, 2H), 7.16-7.21 (m, 1H),7.09-7.15 (m, 2H), 7.02 (d, J=7.8 Hz, 1H), 6.84 (t, J=7.7 Hz, 1H),5.11-5.23 (m, 1H), 4.43 (t, J=8.7 Hz, 2H), 3.07-3.28 (m, 5H), 2.90-3.05(m, 5H), 1.39 (d, J=6.8 Hz, 6H). ESI-MS (m/z): Calcd. for C24H26ClN3O3S:472.1 (M+1). found: 472.1.

Cpd 57: ¹H NMR (CHLOROFORM-d) δ: 8.03 (d, J=2.3 Hz, 1H), 7.32-7.41 (m,2H), 7.24-7.32 (m, 1H), 7.02 (td, J=7.6, 1.1 Hz, 1H), 6.91 (d, J=8.6 Hz,1H), 6.61 (d, J=8.8 Hz, 1H), 5.13 (t, J=7.7 Hz, 1H), 3.90 (s, 3H), 3.56(s, 3H), 3.14 (dt, J=16.0, 7.9 Hz, 2H), 2.89-3.04 (m, 2H), 2.85 (s, 3H),2.83 (s, 6H). ESI-MS (m/z): Calcd. for C22H27N5O4S: 458.2 (M+1). found:458.2.

Cpd 58: ¹H NMR (CHLOROFORM-d) δ: 8.01 (d, J=2.5 Hz, 1H), 7.31-7.39 (m,2H), 7.22-7.26 (m, 1H), 7.01 (td, J=7.6, 1.1 Hz, 1H), 6.91 (dd, J=8.8,1.0 Hz, 1H), 6.53 (d, J=8.6 Hz, 1H), 5.24 (quin, J=6.2 Hz, 1H), 5.12 (t,J=7.8 Hz, 1H), 3.56 (s, 3H), 3.07-3.19 (m, 2H), 2.87-3.03 (m, 2H), 2.85(s, 3H), 2.83 (s, 6H), 1.31 (d, J=6.1 Hz, 6H). ESI-MS (m/z): Calcd. forC24H31N5O4S: 486.2 (M+1). found: 486.2.

Example 9

A. Compound 9a was prepared according to the procedures described inExamples 5 and 7, substituting the appropriate reagents, startingmaterials and purification methods known to those skilled in the art.

B. To a solution of compound 9a (21 mg, 0.06 mmol, 1 eq) in toluene (1mL) was added triethylamine (0.05 mL, 0.36 mmol, 6 eq) and succinicanhydride (7 mg, 0.066 mmol, 1.1 eq) and the reaction mixture wasstirred for 3 days at 110° C. The solution was concentrated.Purification by chromatography (8 g), eluting with 40 to 100%EA/hexanes, gave compound 38 (19.3 mg, 74%). ¹H NMR (CHLOROFORM-d) δ:7.49 (dd, J=7.8, 1.8 Hz, 1H), 7.32 (td, J=8.0, 1.8 Hz, 1H), 7.15-7.23(m, 2H), 7.07 (d, J=8.6 Hz, 2H), 7.03 (td, J=7.6, 1.3 Hz, 1H), 6.83 (dd,J=8.3, 1.0 Hz, 1H), 5.27-5.44 (m, 1H), 3.71 (br. s., 2H), 3.43 (dd,J=14.8, 9.5 Hz, 2H), 3.06 (dd, J=15.2, 9.1 Hz, 2H), 2.75 (s, 4H), 1.01(t, J=6.9 Hz, 3H). ESI-MS (m/z): Calcd. for C24H22ClN3O3: 436.1 (M+1).found: 436.1.

Example 10

To a solution of compound 9a (21 mg, 0.06 mmol, 1 eq) in chloroform (1mL) was added 4-chlorobutyryl chloride (0.014 mL, 0.12 mmol, 2 eq) and20% aqueous potassium carbonate (1 mL). After 3 hrs, the reactionmixture was poured onto a 5 mL extraction tube filled with diatomaceousearth, washed through with DCM, and concentrated. To a solution of thisintermediate in THF (2 mL) in a vial was added NaHMDS (0.3 mL of a 1 Msolution in THF, 0.3 mmol, 5 eq), and the solution was warmed to 65° C.After 4 hrs, NH₄Cl was added, the solution was poured onto a 5 mLextraction tube filled with diatomaceous earth, washed through with DCM,and concentrated. Purification by chromatography (8 g), eluting with EAgave compound 40 (3.2 mg, 13%). ¹H NMR (CHLOROFORM-d) δ: 7.49 (dd,J=7.8, 1.8 Hz, 1H), 7.30-7.36 (m, 1H), 7.18-7.23 (m, 2H), 7.06-7.11 (m,2H), 7.04 (td, J=7.7, 1.3 Hz, 1H), 6.80-6.86 (m, 1H), 5.40-5.52 (m, 1H),3.71 (br. s., 2H), 3.26-3.47 (m, 2H), 3.05-3.22 (m, 2H), 2.85 (dd,J=16.0, 6.2 Hz, 2H), 2.38-2.47 (m, 2H), 1.98-2.10 (m, 2H), 0.99 (t,J=6.9 Hz, 3H). ESI-MS (m/z): Calcd. for C24H24ClN3O2: 422.2 (M+1).found: 422.2.

Example 11

A. Compound 11a was prepared according to the procedures described inExample 5, substituting (S)-ethyloxiranyl acetate for (R)-ethyloxiranylacetate (5b) in Step A, and substituting 4-cyanophenylboronic acid forcpd 5k in Step G.

B. Compound 11b was prepared according to the procedures described inExample 7, Steps B and C, substituting compound 11a for Cpd 26.

C. To a solution of compound 11b (25 mg, 0.07 mmol, 1 eq) in THF (1 mL)was added 4-methyl-1-pentyne (11e) (0.011 mL, 0.11 mmol, 1.5 eq), CuI (7mg, 0.035 mmol, 0.5 eq) and diisopropylethylamine (0.06 mL, 0.35 mmol, 5eq) and the suspension was stirred overnight at rt. DCM was added, thesolution decanted and concentrated. Purification by columnchromatography (8 g) in 40 to 80% EA/hexanes gave compound 128. ¹H NMR(CHLOROFORM-d) δ: 7.54 (d, J=8.3 Hz, 2H), 7.45 (dd, J=7.7, 1.6 Hz, 1H),7.38-7.43 (m, 1H), 7.36 (s, 1H), 7.25 (d, J=8.3 Hz, 2H), 7.08 (t, J=7.7Hz, 1H), 6.91 (d, J=8.3 Hz, 1H), 5.77-5.88 (m, 1H), 3.59 (dt, J=16.3,8.3 Hz, 2H), 3.49 (s, 3H), 3.32 (dd, J=16.3, 6.2 Hz, 2H), 2.60 (d, J=7.1Hz, 2H), 1.91-2.03 (m, 1H), 0.95 (d, J=6.6 Hz, 6H). ESI-MS (m/z): Calcd.for C26H26N6O: 439.2 (M+1). found: 439.2.

Following the procedure described above for Example 11 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 41: ¹H NMR (CHLOROFORM-d) δ: 7.60 (s, 1H), 7.51 (dd, J=7.7, 1.6 Hz,1H), 7.36 (td, J=7.9, 1.6 Hz, 1H), 7.18-7.24 (m, 2H), 7.02-7.12 (m, 3H),6.86 (d, J=7.6 Hz, 1H), 5.91 (t, J=6.7 Hz, 1H), 3.44-3.90 (m, 4H), 3.30(dd, J=16.2, 6.1 Hz, 2H), 1.02 (t, J=6.9 Hz, 3H), 0.32 (s, 9H). ESI-MS(m/z): Calcd. for C25H28ClN5OSi: 478.2 (M+1). found: 478.2.

Cpd 42: ¹H NMR (CHLOROFORM-d) δ: 7.73 (s, 1H), 7.64 (s, 1H), 7.51 (dd,J=7.7, 1.6 Hz, 1H), 7.32-7.40 (m, 1H), 7.18-7.25 (m, 2H), 7.02-7.12 (m,3H), 6.86 (d, J=8.3 Hz, 1H), 5.84-5.98 (m, 1H), 3.43-3.92 (m, 4H), 3.29(dd, J=16.0, 5.4 Hz, 2H), 1.02 (t, J=6.9 Hz, 3H). ESI-MS (m/z): Calcd.for C22H20ClN5O: 406.1 (M+1). found: 406.1.

Cpd 124: ¹H NMR (CHLOROFORM-d) δ: 7.54 (d, J=8.3 Hz, 2H), 7.45 (d, J=7.6Hz, 1H), 7.38-7.44 (m, 1H), 7.35 (s, 1H), 7.25 (d, J=8.3 Hz, 2H), 7.08(t, J=7.6 Hz, 1H), 6.91 (d, J=8.1 Hz, 1H), 5.82 (quin, J=7.1 Hz, 1H),3.58 (dt, J=16.2, 8.2 Hz, 2H), 3.49 (s, 3H), 3.32 (dd, J=16.2, 6.3 Hz,2H), 3.19 (quin, J=8.0 Hz, 1H), 2.05-2.18 (m, 2H), 1.60-1.84 (m, 6H).ESI-MS (m/z): Calcd. for C27H26N6O: 451.2 (M+1). found: 451.2.

Cpd 125: ¹H NMR (CHLOROFORM-d) δ: 8.18 (s, 1H), 7.55 (d, J=8.3 Hz, 2H),7.47 (d, J=7.6 Hz, 1H), 7.38-7.45 (m, 1H), 7.24 (d, J=8.3 Hz, 2H), 7.09(t, J=7.6 Hz, 1H), 6.92 (d, J=8.3 Hz, 1H), 5.86-5.97 (m, 1H), 3.96 (s,3H), 3.57-3.72 (m, 2H), 3.50 (s, 3H), 3.21-3.37 (m, 2H). ESI-MS (m/z):Calcd. for C24H20N6O3: 441.2 (M+1). found: 441.2.

Cpd 128: ¹H NMR (CHLOROFORM-d) δ: 7.71 (s, 1H), 7.51-7.57 (m, 2H), 7.46(dd, J=7.8, 1.7 Hz, 1H), 7.38-7.44 (m, 1H), 7.22-7.27 (m, 2H), 7.04-7.11(m, 1H), 6.88-6.94 (m, 1H), 5.77-5.89 (m, 1H), 5.22 (s, 2H), 3.54-3.67(m, 2H), 3.49 (s, 3H), 3.27-3.39 (m, 2H), 2.08 (s, 3H). ESI-MS (m/z):Calcd. for C25H22N6O3: 455.2 (M+1). found: 455.2.

Cpd 130: ¹H NMR (CHLOROFORM-d) δ: 7.51-7.56 (m, 2H), 7.45 (dd, J=7.7,1.6 Hz, 1H), 7.41 (td, J=7.9, 1.7 Hz, 1H), 7.35 (s, 1H), 7.25 (d, J=8.6Hz, 2H), 7.08 (td, J=7.6, 1.1 Hz, 1H), 6.89-6.94 (m, 1H), 5.76-5.87 (m,1H), 3.58 (dt, J=16.5, 8.4 Hz, 2H), 3.49 (s, 3H), 3.28-3.39 (m, 2H),1.36 (s, 9H). ESI-MS (m/z): Calcd. for C26H26N6O: 439.2 (M+1). found:439.2.

Cpd 136: ¹H NMR (CHLOROFORM-d) δ: 7.53 (d, J=8.6 Hz, 2H), 7.44 (dd,J=7.7, 1.6 Hz, 1H), 7.40 (td, J=7.8, 1.7 Hz, 1H), 7.22-7.26 (m, 2H),7.07 (td, J=7.6, 1.1 Hz, 1H), 6.90 (d, J=8.3 Hz, 1H), 5.50 (t, J=8.2 Hz,1H), 3.54-3.72 (m, 2H), 3.50 (s, 3H), 3.34-3.49 (m, 2H), 2.70 (dq,J=10.5, 7.7 Hz, 4H), 1.31 (t, J=7.6 Hz, 3H), 1.23 (t, J=7.7 Hz, 3H).ESI-MS (m/z): Calcd. for C26H26N6O: 439.2 (M+1). found: 439.2.

Example 12

A. Compound 12a was prepared according to Example 7, Step D,substituting compound 11b for compound 7b.

B. A solution of compound 12a (25 mg, 0.07 mmol, 1 eq), ammonium acetate(22 mg, 0.29 mmol, 4 eq), propionaldehyde (0.021 mL, 0.29 mmol, 1 eq)and glyoxal (0.033 mL of a 40% solution in water, 0.29 mL, 1 eq) inmethanol (1 mL) were heated to 80° C. overnight in a vial. The solutionwas concentrated. Purification by HPLC eluting with 5 to 60% ACN/H₂Ogave compound 134 (16.3 mg, 51%). ¹H NMR (CHLOROFORM-d) δ: 7.54 (d,J=8.3 Hz, 2H), 7.45 (dd, J=7.8, 1.7 Hz, 1H), 7.41 (td, J=7.9, 1.6 Hz,1H), 7.24 (d, J=8.3 Hz, 2H), 7.08 (t, J=7.6 Hz, 1H), 7.01 (s, 1H), 6.98(s, 1H), 6.91 (d, J=8.1 Hz, 1H), 5.32-5.43 (m, 1H), 3.38-3.52 (m, 5H),3.01-3.18 (m, 2H), 2.83 (q, J=7.6 Hz, 2H), 1.93-2.39 (m, 2H), 1.39 (t,J=7.6 Hz, 2H). ESI-MS (m/z): Calcd. for C25H23N5O: 410.2 (M+1). found:410.2.

Following the procedure described above for Example 12 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 39: ¹H NMR (CHLOROFORM-d) δ: 7.63 (s, 1H), 7.50 (dd, J=7.7, 1.6 Hz,1H), 7.32-7.39 (m, 1H), 7.18-7.25 (m, 2H), 7.00-7.12 (m, 5H), 6.82-6.88(m, 1H), 5.35 (quin, J=6.6 Hz, 1H), 3.76 (br. s., 2H), 3.50 (dd, J=16.2,8.1 Hz, 2H), 3.15 (dd, J=15.9, 5.8 Hz, 2H), 1.02 (t, J=7.1 Hz, 3H).ESI-MS (m/z): Calcd. for C23H21ClN4O: 405.1 (M+1). found: 405.1.

Cpd 43: ¹H NMR (CHLOROFORM-d) δ: 7.66 (s, 1H), 7.50 (dd, J=7.8, 1.5 Hz,1H), 7.31-7.40 (m, 1H), 7.18-7.25 (m, 2H), 7.00-7.14 (m, 5H), 6.86 (d,J=8.3 Hz, 1H), 5.28-5.43 (m, 1H), 3.74 (br. s., 2H), 3.37-3.57 (m, 2H),3.00-3.23 (m, 2H), 1.03 (t, J=6.9 Hz, 3H). ESI-MS (m/z): Calcd. forC23H21ClN4O: 405.1 (M+1). found: 405.1.

Cpd 131: ¹H NMR (CHLOROFORM-d) δ: 7.53 (d, J=8.3 Hz, 3H), 7.45 (d, J=7.6Hz, 1H), 7.40 (t, J=8.0 Hz, 1H), 7.23 (d, J=8.3 Hz, 2H), 7.07 (t, J=7.6Hz, 1H), 6.90 (d, J=8.3 Hz, 1H), 5.20 (quin, J=6.8 Hz, 1H), 3.36-3.54(m, 5H), 3.01-3.22 (m, 2H), 2.21 (s, 3H), 2.17 (s, 3H). ESI-MS (m/z):Calcd. for C25H23N5O: 410.2 (M+1). found: 410.2.

Cpd 138: ¹H NMR (CHLOROFORM-d) δ: 7.54 (d, J=8.1 Hz, 2H), 7.46 (d, J=7.8Hz, 1H), 7.41 (t, J=8.0 Hz, 1H), 7.20-7.26 (m, 2H), 7.08 (t, J=7.6 Hz,1H), 6.92 (d, J=8.3 Hz, 1H), 5.39 (m, J=8.3 Hz, 1H), 3.34-3.52 (m, 5H),3.15-3.32 (m, 2H), 2.60 (q, J=7.4 Hz, 2H), 2.51 (q, J=7.4 Hz, 2H), 2.45(s, 3H), 1.22 (t, J=7.6 Hz, 3H), 1.16 (t, J=7.5 Hz, 3H). ESI-MS (m/z):Calcd. for C28H29N5O: 452.2 (M+1). found: 452.2.

Cpd 139: ¹H NMR (CHLOROFORM-d) δ: 7.58 (s, 1H), 7.50-7.56 (m, J=8.3 Hz,2H), 7.45 (dd, J=7.7, 1.6 Hz, 1H), 7.37-7.43 (m, 1H), 7.20-7.26 (m,J=8.3 Hz, 2H), 7.08 (td, J=7.6, 1.1 Hz, 1H), 6.91 (d, J=7.6 Hz, 1H),5.16-5.27 (m, 1H), 3.40-3.55 (m, 5H), 3.03-3.22 (m, 2H), 2.64 (q, J=7.5Hz, 2H), 2.55 (q, J=7.6 Hz, 2H), 1.24 (t, J=7.6 Hz, 3H), 1.19 (t, J=7.6Hz, 3H). ESI-MS (m/z): Calcd. for C27H27N5O: 438.2 (M+1). found: 438.2.

Example 13

A. Compound 13a was prepared according to the procedures described inExample 5, substituting (S)-ethyloxiranyl acetate for (R)-ethyloxiranylacetate (5b) in Step A.

B. To a solution of compound 13a (10 mg, 0.026 mmol, 1 eq) in THF (1 mL)and DMF (0.5 mL) at rt was added NaHMDS (0.13 mL of a 1 M solution inTHF, 0.13 mmol, 5 eq) followed by iodomethane (0.016 mL, 0.26 mmol, 10eq). After 1 hr, water was added, the solution was poured onto a 5 mLextraction tube filled with diatomaceous earth, then DCM was added, andthe organic phases concentrated. Purification by column chromatography(8 g), eluting with 25 to 50% EA/hexanes, gave compound 49 (7.2 mg,73%). ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.18-7.23 (m, 2H),7.04-7.10 (m, 2H), 7.01 (td, J=7.6, 1.0 Hz, 1H), 6.87 (d, J=8.3 Hz, 1H),4.54-4.64 (m, 1H), 3.48 (s, 3H), 3.43 (s, 3H), 3.11-3.23 (m, 2H),2.78-2.94 (m, 2H). ESI-MS (m/z): Calcd. for C20H19ClN2O2: 355.1 (M+1).found: 355.1.

Following the procedure described above for Example 13 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compound was prepared:

Cpd 69: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.42 (m, 2H), 7.18-7.24 (m, 2H),7.05-7.11 (m, 2H), 6.98-7.04 (m, 1H), 6.88 (d, J=8.3 Hz, 1H), 4.98 (t,J=6.4 Hz, 1H), 3.49 (s, 3H), 3.14 (td, J=15.1, 6.9 Hz, 2H), 2.72-2.87(m, 2H), 0.19 (s, 9H). ESI-MS (m/z): Calcd. for C22H25ClN2O2Si: 413.1(M+1). found: 413.1.

Example 14

To a solution of compound 51 (50 mg, 0.15 mmol, 1 eq) in HMPA (2 mL) wasadded sodium hydride (18 mg of a 60% dispersion in oil, 0.44 mmol, 3eq). The solution bubbled and turned purplish and after 30 min,2-iodopropane (0.029 mL, 0.29 mmol, 2 eq) was added and the solutionstirred overnight at rt. Additional sodium hydride (20 mg) and2-iodopropane (0.029 mL) were added, and the reaction was heated againto 50° C. overnight. 15-crown-5 (10 mg) was added, and the reaction washeated to 50° C. for 2 days. A solution of NH₄Cl was added, the reactionmixture was extracted with DCM, the organic phases combined, dried overMgSO₄, filtered, and concentrated. Purification by column chromatography(8 g), eluting with 25 to 50% EA/hexanes, gave compound 67 (3.4 mg, 6%).¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.30-7.36 (m,1H), 7.16-7.23 (m, 2H), 7.04-7.10 (m, 2H), 6.97-7.04 (m, 1H), 6.84-6.90(m, 1H), 4.72-4.82 (m, 1H), 3.77 (dt, J=12.3, 6.1 Hz, 1H), 3.49 (s, 3H),3.10-3.23 (m, 2H), 2.74-2.90 (m, 2H), 1.22 (dd, J=6.1, 1.3 Hz, 6H).ESI-MS (m/z): Calcd. for C22H23ClN2O2: 383.2 (M+1). found: 383.2.

Example 15

To a solution of compound 13a (25 mg, 0.07 mmol, 1 eq) in THF (2 mL) wasadded phenol (9 mg, 0.09 mmol, 1.25 eq), DIAD (0.018 mL, 0.09 mmol, 1.25eq) and triphenylphosphine (24 mg, 0.09 mmol, 1.25 eq) and the solutionwas heated to 50° C. overnight. The solution was concentrated.Purification by column chromatography (8 g), eluting with 20 to 40%EA/hexanes, gave Cpd 58. Further purification by HPLC eluting with 10 to100% ACN/H₂O gave Cpd 58 (12.8 mg, 41%). ¹H NMR (CHLOROFORM-d) δ: 7.40(dd, J=7.8, 1.8 Hz, 1H), 7.28-7.38 (m, 3H), 7.17-7.23 (m, 2H), 7.05-7.11(m, 2H), 7.00-7.05 (m, 1H), 6.92-7.00 (m, 3H), 6.89 (d, J=7.3 Hz, 1H),5.51 (tt, J=6.9, 3.6 Hz, 1H), 3.50 (s, 3H), 3.31-3.44 (m, 2H), 2.98-3.14(m, 2H). ESI-MS (m/z): Calcd. for C25H21ClN2O2: 417.1 (M+1). found:417.1.

Following the procedure described above for Example 15 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compound was prepared:

Cpd 59: ¹H NMR (CHLOROFORM-d) δ: 8.36 (t, J=1.8 Hz, 1H), 8.25 (t, J=3.0Hz, 1H), 7.41 (dd, J=7.7, 1.6 Hz, 1H), 7.32-7.38 (m, 1H), 7.23-7.26 (m,2H), 7.17-7.23 (m, 2H), 7.05-7.11 (m, 2H), 7.03 (td, J=7.6, 1.3 Hz, 1H),6.89 (dd, J=8.3, 1.0 Hz, 1H), 5.54 (tt, J=6.9, 3.5 Hz, 1H), 3.51 (s,3H), 3.34-3.46 (m, 2H), 2.99-3.16 (m, 2H). ESI-MS (m/z): Calcd. forC24H20ClN3O2: 418.1 (M+1). found: 418.1.

Example 16

To a solution of compound 13a (15 mg, 0.044 mmol, 1 eq) in toluene (2mL) was added 2-bromopyridine (16a) (14 mg, 0.09 mmol, 2 eq),3,4,7,8-tetramethyl-1,10-phenanthroline (1 mg, 0.004 mmol, 0.1 eq)cesium carbonate (22 mg, 0.066 mmol, 1.5 eq) and CuI (1 mg, 0.004 mmol,0.1 eq) and the suspension heated to 110° C. for 3 hrs, then to 140° C.overnight. The reaction was filtered through a short silica column withEA and concentrated. Purification by column chromatography (12 g),eluting with 30 to 100% EA/hexanes, gave compound 61 (3 mg, 15%). ¹H NMR(CHLOROFORM-d) δ: 8.19 (dd, J=5.1, 1.3 Hz, 1H), 7.58 (ddd, J=8.5, 6.9,2.0 Hz, 1H), 7.41 (dd, J=7.7, 1.6 Hz, 1H), 7.31-7.38 (m, 1H), 7.16-7.23(m, 2H), 7.06-7.12 (m, 2H), 6.98-7.06 (m, 1H), 6.84-6.93 (m, 2H), 6.75(d, J=8.3 Hz, 1H), 6.13 (dt, J=6.9, 3.3 Hz, 1H), 3.50 (s, 3H), 3.37-3.48(m, 2H), 2.91-3.11 (m, 2H). ESI-MS (m/z): Calcd. for C24H20ClN3O2: 418.1(M+1). found: 418.1.

Example 17

A. To a solution of compound 51(670 mg, 1.97 mmol, 1 eq) in DCM (60 mL)at 0° C. was added Dess-Martin periodinane (917 mg, 2.16 mmol, 1.1 eq)and the reaction was stirred for 1.5 hrs. Saturated NaHCO₃ and sodiumthiosulfate were added and the reaction mixture was stirred 30 min. Atthat time, the aqueous phase was extracted with DCM, the organic phasescombined, dried over MgSO₄, filtered, and concentrated. Purification bycolumn chromatography (40 g), eluting with 25 to 50% EA/hexanes, gavecompound 35 (579 mg, 87%). ¹H NMR (CHLOROFORM-d) δ: 7.35-7.44 (m, 2H),7.21-7.26 (m, 3H), 7.07-7.12 (m, 2H), 7.05 (td, J=7.6, 1.1 Hz, 1H),6.88-6.94 (m, 1H), 3.47-3.58 (m, 7H). ESI-MS (m/z): Calcd. forC19H15ClN2O2: 339.1 (M+1). found: 339.0.

B. To a solution of compound 35 (271 mg, 0.8 mmol, 1 eq) in THF (17 mL)at −78° C. under Ar_((g)) was added KHMDS (1.92 mL of a 0.5 M solutionin toluene, 0.96 mmol, 1.2 eq). After 30 min,N-phenyl-bis(trifluoromethanesulfonimide) (343 mg, 0.96 mmol, 1.2 eq)was added in THF (3 mL), and the reaction mixture was warmed to rt over2 hrs. Methanol was added and the solution concentrated. Purification bycolumn chromatography (24 g), eluting with 15 to 30% EA/hexanes, gavecompound 17a (131 mg, 35%, 60:40 mix of isomers). ESI-MS (m/z): Calcd.for C20H14ClF3N2O4S: 471.1 (M+1). found: 471.1.

C. To a solution of compound 17a (15 mg, 0.032 mmol, 1 eq) in DME (1.6mL) was added Pd(Ph₃P)₄ (4 mg, 0.0032 mmol, 0.1 eq), 2 M sodiumcarbonate (0.25 mL) and2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(17b) (17 mL, 0.064 mmol, 2 eq). The solution was degassed by bubblingAr_((g)), then heated to 80° C. for 30 min. The solution was poured ontoa 5 mL extraction tube filled with diatomaceous earth, DCM was added andthe organic phase concentrated. The residue was dissolved in ethylacetate (5 mL) and methanol (3 mL), PtO₂ (5 mg) was added, and thereaction mixture was placed under a hydrogen gas atmosphere overnight.The catalyst was filtered through diatomaceous earth, and the filtrateconcentrated. Purification by column chromatography (8 g), eluting with20 to 40% EA/hexanes, gave impure compound 60 (—Cl present). Furtherpurification by HPLC, eluting with 10 to 70% ACN/H₂O gave compound 60(2.6 mg, 17%) in the desired purity. ¹H NMR (CHLOROFORM-d) δ: 8.11 (d,J=2.5 Hz, 1H), 7.57 (dd, J=8.5, 2.7 Hz, 1H), 7.42 (dd, J=7.7, 1.6 Hz,1H), 7.32-7.39 (m, 1H), 7.17-7.23 (m, 2H), 7.06-7.12 (m, 2H), 7.00-7.06(m, 1H), 6.86-6.93 (m, 1H), 6.67 (d, J=8.6 Hz, 1H), 5.28 (quin, J=6.2Hz, 1H), 3.99-4.12 (m, 1H), 3.51 (s, 3H), 3.26 (td, J=16.2, 8.5 Hz, 2H),2.83-3.01 (m, 2H), 1.35 (d, J=6.3 Hz, 6H). ESI-MS (m/z): Calcd. forC27H26ClN3O2: 460.2 (M+1). found: 460.2.

Following the procedure described above for Example 17 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 63: ¹H NMR (CHLOROFORM-d) δ: 8.63 (d, J=2.0 Hz, 1H), 8.51 (dd,J=4.8, 1.5 Hz, 1H), 7.69 (d, J=8.1 Hz, 1H), 7.42 (dd, J=7.7, 1.6 Hz,1H), 7.32-7.40 (m, 1H), 7.27-7.31 (m, 1H), 7.17-7.24 (m, J=8.6 Hz, 2H),7.07-7.12 (m, J=8.6 Hz, 2H), 7.00-7.07 (m, 1H), 6.90 (d, J=8.3 Hz, 1H),4.06-4.19 (m, 1H), 3.52 (s, 3H), 3.33 (td, J=15.3, 8.5 Hz, 2H),2.89-3.08 (m, 2H). ESI-MS (m/z): Calcd. for C24H20ClN3O: 402.1 (M+1).found: 402.1.

Cpd 64: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.8, 1.8 Hz, 1H), 7.30-7.36(m, 1H), 7.17-7.22 (m, 2H), 7.05-7.11 (m, 2H), 7.01 (td, J=7.6, 1.3 Hz,1H), 6.88 (d, J=8.3 Hz, 1H), 3.49 (s, 3H), 2.84-2.98 (m, 2H), 2.63-2.75(m, 1H), 2.49-2.62 (m, 2H), 1.62-1.73 (m, 2H), 1.42 (d, J=6.6 Hz, 2H),1.17-1.30 (m, 5H), 0.91 (d, J=4.8 Hz, 6H). ESI-MS (m/z): Calcd. forC27H31ClN2O: 435.2 (M+1). found: 435.2.

Cpd 65: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.18-7.23 (m, 2H),7.06-7.11 (m, 2H), 6.94-7.04 (m, 3H), 6.88 (dd, J=8.3, 1.0 Hz, 1H), 6.64(td, J=7.4, 1.1 Hz, 1H), 6.50 (d, J=8.1 Hz, 1H), 3.40-3.51 (m, 4H),2.61-3.10 (m, 8H), 2.17 (s, 1H). ESI-MS (m/z): Calcd. for C28H26ClN3O:456.2 (M+1). found: 456.2.

Cpd 66: ¹H NMR (CHLOROFORM-d) δ: 9.12 (d, J=2.0 Hz, 1H), 8.78 (d, J=2.3Hz, 1H), 8.30 (t, J=2.0 Hz, 1H), 7.43 (dd, J=7.7, 1.6 Hz, 1H), 7.32-7.40(m, 1H), 7.17-7.24 (m, 2H), 7.07-7.14 (m, 2H), 7.04 (td, J=7.6, 1.3 Hz,1H), 6.90 (dd, J=8.3, 1.0 Hz, 1H), 4.43 (q, J=7.2 Hz, 2H), 4.20 (t,J=8.3 Hz, 1H), 3.53 (s, 3H), 3.28-3.43 (m, 2H), 3.04 (dd, J=15.5, 8.5Hz, 2H), 1.37-1.47 (m, 3H). ESI-MS (m/z): Calcd. for C27H24ClN3O3: 474.2(M+1). found: 474.2.

Cpd 73: ¹H NMR (CHLOROFORM-d) δ: 8.46-8.55 (m, 1H), 7.58 (dd, J=8.0, 2.1Hz, 1H), 7.42 (dd, J=7.7, 1.6 Hz, 1H), 7.32-7.40 (m, 1H), 7.18-7.25 (m,2H), 7.06-7.17 (m, 3H), 6.99-7.06 (m, 1H), 6.90 (d, J=8.1 Hz, 1H), 4.10(quin, J=8.3 Hz, 1H), 3.52 (s, 3H), 3.30 (td, J=15.5, 8.5 Hz, 2H),2.85-3.05 (m, 2H), 2.55 (s, 3H). ESI-MS (m/z): Calcd. for C25H22ClN3O:416.2 (M+1). found: 416.2.

Cpd 74: ¹H NMR (CHLOROFORM-d) δ: 8.12 (d, J=2.5 Hz, 1H), 7.59 (dd,J=8.6, 2.5 Hz, 1H), 7.42 (dd, J=7.7, 1.6 Hz, 1H), 7.36 (td, J=8.0, 1.8Hz, 1H), 7.17-7.24 (m, 2H), 7.06-7.12 (m, 2H), 7.03 (td, J=7.6, 1.1 Hz,1H), 6.85-6.93 (m, 1H), 6.72 (d, J=8.6 Hz, 1H), 4.35 (q, J=7.1 Hz, 2H),4.06 (quin, J=8.3 Hz, 1H), 3.51 (s, 3H), 3.27 (td, J=16.3, 8.3 Hz, 2H),2.83-3.01 (m, 2H), 1.40 (t, J=7.1 Hz, 3H). ESI-MS (m/z): Calcd. forC26H24ClN3O2: 446.2 (M+1). found: 446.2.

Cpd 75: ¹H NMR (CHLOROFORM-d) δ: 7.67 (d, J=7.8 Hz, 1H), 7.42 (dd,J=7.8, 1.5 Hz, 1H), 7.33-7.39 (m, 1H), 7.20 (d, J=8.6 Hz, 2H), 7.06-7.13(m, 3H), 7.00-7.06 (m, 1H), 6.90 (d, J=8.1 Hz, 1H), 4.50 (quin, J=7.8Hz, 1H), 3.52 (s, 3H), 3.34 (dd, J=15.9, 8.6 Hz, 2H), 2.80-3.12 (m, 3H),1.29 (d, J=7.1 Hz, 6H). ESI-MS (m/z): Calcd. for C27H25Cl2N3O: 478.1(M+1). found: 478.1.

Cpd 77: ¹H NMR (CHLOROFORM-d) δ: 8.44 (d, J=2.0 Hz, 1H), 7.54 (dd,J=8.0, 2.1 Hz, 1H), 7.41 (dd, J=7.7, 1.6 Hz, 1H), 7.35 (td, J=8.0, 1.8Hz, 1H), 7.17-7.23 (m, 2H), 7.06-7.13 (m, 3H), 7.03 (td, J=7.6, 1.1 Hz,1H), 6.86-6.92 (m, 1H), 4.07 (quin, J=8.3 Hz, 1H), 3.51 (s, 3H),3.19-3.35 (m, 2H), 2.82-3.03 (m, 2H), 1.98-2.08 (m, 1H), 0.94-1.04 (m,4H). ESI-MS (m/z): Calcd. for C27H24ClN3O: 442.2 (M+1). found: 442.2.

Example 18

To a suspension of compound 5l (25 mg, 0.07 mmol, 1 eq) indichloroethane (2 mL) was added 3,4-dihydro-2H-pyran (18a) (33 mg, 0.37mmol, 5 eq) and p-toluenesulfonic acid (13 mg, 0.07 mmol, 1 eq) and thereaction mixture stirred at rt for 2 hrs. MP-carbonate was added,stirred 20 min, filtered and concentrated. Purification by columnchromatography (8 g), eluting with 20 to 40% EA/hexanes, gave compound76 (16.4 mg, 50%). ¹H NMR (CHLOROFORM-d) δ: 7.30-7.42 (m, 2H), 7.16-7.23(m, 2H), 7.04-7.11 (m, 2H), 7.01 (t, J=7.7 Hz, 1H), 6.84-6.91 (m, 1H),4.96-5.07 (m, 1H), 4.74-4.82 (m, 1H), 3.94 (ddd, J=11.1, 7.6, 3.3 Hz,1H), 3.52-3.61 (m, 1H), 3.49 (d, J=2.8 Hz, 3H), 3.11-3.31 (m, 2H),2.74-3.04 (m, 2H), 1.69-1.95 (m, 2H), 1.46-1.65 (m, 4H). ESI-MS (m/z):Calcd. for C24H25ClN2O3: 425.2 (M+1). found: 425.2.

Example 19

A. To a solution of compound 5l (40 mg, 0.12 mmol, 1 eq) in THF (2 mL)was added sodium hydride (23 mg of 60% dispersion in oil, 0.59 mmol, 5eq). After 30 min, cyclohexanecarbonyl chloride (0.08 mL, 0.59 mmol, 5eq) was added and the solution was stirred overnight at rt. SaturatedNH₄Cl was added and the solution was poured onto a 5 mL extraction tubefilled with diatomaceous earth. The extraction tube filled withdiatomaceous earth was washed with DCM and the filtrate wasconcentrated. Purification by column chromatography (8 g), eluting with20 to 40% EA/hexanes, gave compound 78 (30 mg, 56%) ¹H NMR(CHLOROFORM-d) δ: 7.39 (dd, J=7.8, 1.5 Hz, 1H), 7.32-7.38 (m, 1H),7.17-7.24 (m, 2H), 7.04-7.09 (m, 2H), 7.02 (td, J=7.6, 1.1 Hz, 1H), 6.89(dd, J=8.3, 1.0 Hz, 1H), 5.82 (tt, J=7.3, 3.9 Hz, 1H), 3.50 (s, 3H),3.27-3.39 (m, 2H), 2.75-2.94 (m, 2H), 2.32 (tt, J=11.2, 3.7 Hz, 1H),1.92 (d, J=12.9 Hz, 2H), 1.71-1.80 (m, 2H), 1.61-1.68 (m, 1H), 1.40-1.52(m, 2H), 1.22-1.35 (m, 3H). ESI-MS (m/z): Calcd. for C26H27ClN2O3: 451.2(M+1). found: 451.2.

B. To a solution of compound 78 (21 mg, 0.047 mmol, 1 eq) in chloroform(1 mL) at rt was added triethylsilane (0.3 mL, 1.86 mmol, 40 eq)followed by indium bromide (330 mg, 0.93 mmol, 20 eq). The suspensionwas placed under an Argon atmosphere in a vial and stirred overnight at65° C. Water was added and the mixture was stirred until the orangecolor disappeared. The reaction mixture was poured onto a 5 mLextraction tube filled with diatomaceous earth, the tube was flushedwith DCM, and the filtrate was concentrated. Purification by columnchromatography (8 g), eluting with 10 to 20% EA/hexanes, gave compound82 (4.8 mg, 23%). ¹H NMR (CHLOROFORM-d) δ: 7.29-7.43 (m, 2H), 7.16-7.23(m, J=8.6 Hz, 2H), 7.04-7.10 (m, J=8.6 Hz, 2H), 7.01 (t, J=7.6 Hz, 1H),6.87 (d, J=8.1 Hz, 1H), 4.59-4.70 (m, 1H), 3.49 (s, 3H), 3.27-3.37 (m,2H), 3.10-3.22 (m, 2H), 2.84 (ddd, J=21.6, 15.9, 5.2 Hz, 2H), 1.59-1.84(m, 6H), 1.17-1.33 (m, 3H), 0.89-1.01 (m, 2H). ESI-MS (m/z): Calcd. forC26H29ClN2O2: 437.2 (M+1). found: 437.2.

Following the procedure described above for Example 19 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 55: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.32-7.38(m, 1H), 7.17-7.24 (m, 2H), 7.05-7.10 (m, 2H), 6.98-7.05 (m, 1H), 6.89(dd, J=8.3, 1.0 Hz, 1H), 5.87 (tt, J=7.5, 3.9 Hz, 1H), 3.50 (s, 3H),3.29-3.41 (m, 2H), 2.78-2.96 (m, 2H), 2.23 (tt, J=8.6, 5.5 Hz, 1H),1.46-1.73 (m, 4H), 0.91 (td, J=7.5, 1.0 Hz, 6H). ESI-MS (m/z): Calcd.for C25H27ClN2O3: 439.2 (M+1). found: 439.2.

Cpd 70: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.32-7.38(m, 1H), 7.16-7.24 (m, 2H), 7.05-7.10 (m, 2H), 7.02 (td, J=7.6, 1.1 Hz,1H), 6.86-6.92 (m, 1H), 5.82-5.91 (m, 1H), 3.47-3.53 (m, 3H), 3.30-3.40(m, 2H), 2.78-2.96 (m, 2H), 2.23 (tt, J=8.6, 5.6 Hz, 1H), 1.47-1.72 (m,4H), 0.86-0.96 (m, 6H). ESI-MS (m/z): Calcd. for C25H27ClN2O3: 439.2(M+1). found: 439.2.

Cpd 72: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.16-7.22 (m, 2H),7.04-7.10 (m, 2H), 7.01 (td, J=7.7, 1.3 Hz, 1H), 6.88 (dd, J=8.3, 1.0Hz, 1H), 4.61-4.70 (m, 1H), 3.49 (s, 3H), 3.36-3.45 (m, 2H), 3.11-3.23(m, 2H), 2.77-2.91 (m, 2H), 1.29-1.54 (m, 5H), 0.90 (t, J=7.5 Hz, 6H).ESI-MS (m/z): Calcd. for C25H29ClN2O2: 425.2 (M+1). found: 425.2.

Cpd 79: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.42 (m, 2H), 7.17-7.23 (m, 2H),7.05-7.09 (m, 2H), 6.99-7.05 (m, 1H), 6.89 (dd, J=8.3, 1.0 Hz, 1H), 5.83(tt, J=7.4, 3.9 Hz, 1H), 3.50 (s, 3H), 3.34 (dd, J=16.7, 7.3 Hz, 2H),2.80-2.95 (m, 2H), 2.75 (quin, J=8.0 Hz, 1H), 1.56-1.96 (m, 8H). ESI-MS(m/z): Calcd. for C25H25ClN2O3: 437.2 (M+1). found: 437.2.

Cpd 80: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H), 7.35 (td,J=7.9, 1.6 Hz, 1H), 7.17-7.23 (m, 2H), 7.04-7.09 (m, 2H), 7.02 (td,J=7.6, 1.1 Hz, 1H), 6.86-6.92 (m, 1H), 5.83 (tt, J=7.3, 3.8 Hz, 1H),3.50 (s, 3H), 3.34 (dd, J=16.7, 7.3 Hz, 2H), 3.16 (quin, J=8.3 Hz, 1H),2.78-2.96 (m, 2H), 2.13-2.37 (m, 4H), 1.84-2.04 (m, 2H). ESI-MS (m/z):Calcd. for C24H23ClN2O3: 423.1 (M+1). found: 423.1.

Cpd 81: ¹H NMR (CHLOROFORM-d) δ: 7.31-7.43 (m, 2H), 7.16-7.24 (m, J=8.6Hz, 2H), 7.05-7.10 (m, J=8.3 Hz, 2H), 7.02 (t, J=7.6 Hz, 1H), 6.89 (d,J=8.3 Hz, 1H), 5.83 (tt, J=7.3, 3.8 Hz, 1H), 3.50 (s, 3H), 3.34 (dd,J=16.7, 7.3 Hz, 2H), 2.77-2.96 (m, 2H), 2.57 (dt, J=14.0, 6.9 Hz, 1H),1.19 (dd, J=7.1, 1.0 Hz, 6H). ESI-MS (m/z): Calcd. for C23H23ClN2O3:411.1 (M+1). found: 411.1.

Cpd 83: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.30-7.36(m, 1H), 7.16-7.23 (m, 2H), 7.04-7.10 (m, J=8.6 Hz, 2H), 7.01 (td,J=7.6, 1.0 Hz, 1H), 6.88 (d, J=8.3 Hz, 1H), 4.63-4.72 (m, 1H), 3.46-3.51(m, 3H), 3.35-3.45 (m, 2H), 3.11-3.23 (m, 2H), 2.77-2.93 (m, 2H), 2.18(dt, J=15.0, 7.4 Hz, 1H), 1.70-1.83 (m, 2H), 1.47-1.65 (m, 4H),1.19-1.33 (m, 2H). ESI-MS (m/z): Calcd. for C25H27ClN2O2: 423.2 (M+1).found: 423.2.

Cpd 84: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.30-7.36(m, 1H), 7.16-7.23 (m, 2H), 7.04-7.09 (m, 2H), 7.01 (td, J=7.6, 1.1 Hz,1H), 6.88 (d, J=8.3 Hz, 1H), 4.62-4.72 (m, 1H), 3.43-3.57 (m, 5H),3.11-3.23 (m, 2H), 2.76-2.92 (m, 2H), 2.60 (dt, J=14.8, 7.4 Hz, 1H),2.03-2.15 (m, 2H), 1.83-2.00 (m, 2H), 1.69-1.81 (m, 2H). ESI-MS (m/z):Calcd. for C24H25ClN2O2: 409.2 (M+1). found: 409.2.

Cpd 85: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.45 (m, 2H), 7.20 (d, J=8.6 Hz,2H), 7.05-7.13 (m, 2H), 6.97-7.05 (m, 1H), 6.88 (d, J=8.3 Hz, 1H),4.62-4.74 (m, 1H), 3.49 (s, 3H), 3.25-3.37 (m, 2H), 3.11-3.25 (m, 2H),2.76-2.96 (m, 2H), 1.81-1.98 (m, 1H), 0.94 (d, J=6.6 Hz, 6H). ESI-MS(m/z): Calcd. for C23H25ClN2O2: 397.2 (M+1). found: 397.2.

Cpd 86: ¹H NMR (CHLOROFORM-d) δ: 7.32-7.42 (m, 2H), 7.17-7.23 (m, 2H),7.05-7.09 (m, 2H), 6.99-7.05 (m, 1H), 6.89 (dd, J=8.3, 1.0 Hz, 1H), 5.85(tt, J=7.3, 3.7 Hz, 1H), 3.97 (d, J=11.9 Hz, 2H), 3.50 (s, 3H),3.29-3.48 (m, 4H), 2.78-2.95 (m, 2H), 2.51-2.62 (m, 1H), 1.73-1.90 (m,4H). ESI-MS (m/z): Calcd. for C25H25ClN2O4: 453.2 (M+1). found: 453.2.

Cpd 87: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.42 (m, 2H), 7.16-7.23 (m, J=8.6Hz, 2H), 7.04-7.10 (m, J=8.3 Hz, 2H), 7.01 (t, J=7.6 Hz, 1H), 6.88 (d,J=8.3 Hz, 1H), 4.61-4.71 (m, 1H), 3.98 (dd, J=11.2, 3.9 Hz, 2H), 3.49(s, 3H), 3.33-3.45 (m, 4H), 3.11-3.23 (m, 2H), 2.76-2.91 (m, 2H), 1.87(br. s., 1H), 1.67 (br. s., 2H), 1.29-1.43 (m, 2H). ESI-MS (m/z): Calcd.for C25H27ClN2O3: 439.2 (M+1). found: 439.2.

Example 20

To a solution of compound 35 (24 mg, 0.07 mmol, 1 eq) and2,2-dimethyl-1,3-propanediol (148 mg, 1.42 mmol, 20 eq) in DCM (1 mL)was added BF₃-etherate (0.009 mL, 0.07 mmol, 1 eq) and the solution wasstirred overnight at rt. Water was added, and the aqueous phase wasextracted with EA. The organic phases were combined, washed with brine,dried and over MgSO₄, filtered, and concentrated. Purification by columnchromatography (8 g), eluting with 15 to 30% EA/hexanes, gave compound71 (27.8 mg, 88%). ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz,1H), 7.30-7.36 (m, 1H), 7.16-7.23 (m, 2H), 7.03-7.09 (m, 2H), 7.01 (td,J=7.6, 1.1 Hz, 1H), 6.84-6.89 (m, 1H), 3.61 (q, J=11.1 Hz, 4H), 3.47 (s,3H), 3.26 (s, 2H), 3.20 (s, 2H), 1.08 (s, 3H), 1.00 (s, 3H). ESI-MS(m/z): Calcd. for C24H25ClN2O3: 425.2 (M+1). found: 425.2.

Following the procedure described above for Example 20 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 52: ¹H NMR (CHLOROFORM-d) δ: 7.33 (d, J=8.3 Hz, 1H), 7.19-7.26 (m,2H), 7.03-7.08 (m, 2H), 7.00 (dd, J=8.3, 2.0 Hz, 1H), 6.85 (d, J=2.0 Hz,1H), 3.95-4.09 (m, 4H), 3.47 (s, 3H), 3.27 (s, 2H), 3.18 (s, 2H),1.83-1.97 (m, 1H), 1.69-1.81 (m, 1H). ESI-MS (m/z): Calcd. forC22H2OCl2N2O3: 431.1 (M+1). found: 431.1.

Cpd 54: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.8, 1.8 Hz, 1H), 7.34 (td,J=8.0, 1.8 Hz, 1H), 7.17-7.23 (m, 2H), 7.03-7.08 (m, 2H), 7.01 (td,J=7.6, 1.1 Hz, 1H), 6.87 (dd, J=8.3, 1.0 Hz, 1H), 3.97-4.09 (m, 4H),3.47 (s, 3H), 3.28 (s, 2H), 3.19 (s, 2H), 1.84-1.97 (m, 1H), 1.69-1.80(m, 1H). ESI-MS (m/z): Calcd. for C22H21ClN2O3: 397.1 (M+1). found:397.1.

Cpd 91: ¹H NMR (CHLOROFORM-d) δ: 7.49-7.55 (m, J=8.3 Hz, 2H), 7.42 (dd,J=7.8, 1.5 Hz, 1H), 7.32-7.40 (m, 1H), 7.20-7.25 (m, J=8.3 Hz, 2H), 7.04(t, J=7.7 Hz, 1H), 6.87 (d, J=8.3 Hz, 1H), 3.62 (q, J=11.4 Hz, 4H), 3.45(s, 3H), 3.25 (d, J=15.7 Hz, 4H), 1.09 (s, 3H), 1.00 (s, 3H). ESI-MS(m/z): Calcd. for C25H25N3O3: 416.2 (M+1). found: 416.2.

Cpd 93: ¹H NMR (CHLOROFORM-d) δ: 7.29-7.39 (m, 2H), 6.94-7.05 (m, 3H),6.90 (d, J=8.1 Hz, 1H), 6.56 (d, J=8.8 Hz, 2H), 3.57-3.69 (m, 4H), 3.55(s, 3H), 3.23 (d, J=11.4 Hz, 4H), 2.91 (s, 6H), 1.07 (s, 3H), 1.00 (s,3H). ESI-MS (m/z): Calcd. for C26H31N3O3: 434.2 (M+1). found: 434.2.

Cpd 94: ¹H NMR (CHLOROFORM-d) δ: 8.02 (d, J=2.3 Hz, 1H), 7.30-7.41 (m,2H), 7.22-7.27 (m, 1H), 7.00 (t, J=7.3 Hz, 1H), 6.89 (d, J=8.3 Hz, 1H),6.56 (d, J=8.6 Hz, 1H), 4.31 (q, J=7.0 Hz, 2H), 3.56-3.68 (m, 4H), 3.54(s, 3H), 3.26 (s, 2H), 3.21 (s, 2H), 1.36 (t, J=7.1 Hz, 3H), 1.07 (s,3H), 1.01 (s, 3H). ESI-MS (m/z): Calcd. for C25H29N3O4: 436.2 (M+1).found: 436.2.

Cpd 95: ¹H NMR (CHLOROFORM-d) δ: 8.31-8.41 (m, 1H), 7.31-7.44 (m, 2H),7.25 (d, J=2.3 Hz, 1H), 6.96-7.06 (m, 2H), 6.88 (d, J=8.3 Hz, 1H), 3.62(q, J=11.3 Hz, 4H), 3.51 (s, 3H), 3.27 (s, 2H), 3.23 (s, 2H), 2.50 (s,3H), 1.08 (s, 3H), 1.00 (s, 3H). ESI-MS (m/z): Calcd. for C24H27N3O3:406.2 (M+1). found: 406.2.

Cpd 96: ¹H NMR (CHLOROFORM-d) δ: 8.04 (d, J=2.3 Hz, 1H), 7.30-7.41 (m,2H), 7.22-7.29 (m, 3H), 7.00 (t, J=7.6 Hz, 1H), 6.89 (d, J=8.3 Hz, 1H),6.59 (d, J=8.6 Hz, 1H), 3.90 (s, 3H), 3.56-3.68 (m, 4H), 3.54 (s, 3H),3.26 (s, 2H), 3.21 (s, 2H), 1.07 (s, 3H), 1.01 (s, 3H). ESI-MS (m/z):Calcd. for C24H27N3O4: 422.2 (M+1). found: 422.2.

Cpd 97: ¹H NMR (CHLOROFORM-d) δ: 8.08 (d, J=2.3 Hz, 1H), 7.29-7.39 (m,2H), 7.10 (dd, J=9.0, 2.4 Hz, 1H), 6.98 (t, J=7.6 Hz, 1H), 6.91 (d,J=8.1 Hz, 1H), 6.33 (d, J=9.1 Hz, 1H), 3.53-3.67 (m, 7H), 3.25 (s, 2H),3.21 (s, 2H), 3.05 (s, 6H), 1.05 (s, 3H), 1.01 (s, 3H). ESI-MS (m/z):Calcd. for C25H30N4O3: 435.2 (M+1). found: 435.2.

Cpd 98: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.30-7.36(m, 1H), 7.16-7.22 (m, J=8.6 Hz, 2H), 7.03-7.09 (m, 2H), 7.00 (t, J=7.6Hz, 1H), 6.87 (d, J=8.1 Hz, 1H), 3.69-3.82 (m, 2H), 3.47 (s, 3H),3.06-3.24 (m, 4H), 1.29-1.36 (m, 6H). ESI-MS (m/z): Calcd. forC23H23ClN2O3: 411.1 (M+1). found: 411.1.

Cpd 99: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H), 7.33 (td,J=7.9, 1.6 Hz, 1H), 7.16-7.23 (m, 2H), 7.03-7.09 (m, 2H), 7.01 (td,J=7.7, 1.3 Hz, 1H), 6.83-6.91 (m, 1H), 3.68-3.83 (m, 2H), 3.47 (s, 3H),3.05-3.23 (m, 4H), 1.32 (dd, J=5.6, 1.5 Hz, 6H). ESI-MS (m/z): Calcd.for C23H23ClN2O3: 411.1 (M+1). found: 411.1.

Cpd 100: ¹H NMR (CHLOROFORM-d) δ: 7.31 (dd, J=7.7, 1.6 Hz, 1H),7.22-7.29 (m, 1H), 7.08-7.15 (m, J=8.6 Hz, 2H), 6.96-7.02 (m, J=8.3 Hz,2H), 6.90-6.96 (m, 1H), 6.80 (d, J=8.3 Hz, 1H), 3.93-4.10 (m, 2H), 3.40(s, 3H), 3.03-3.23 (m, 4H), 1.65 (t, J=7.3 Hz, 2H), 1.13-1.27 (m, 8H).ESI-MS (m/z): Calcd. for C24H25ClN2O3: 425.2 (M+1). found: 425.2.

Cpd 101: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H),7.30-7.36 (m, 1H), 7.15-7.21 (m, 2H), 7.03-7.08 (m, 2H), 7.00 (td,J=7.6, 1.1 Hz, 1H), 6.87 (d, J=8.3 Hz, 1H), 4.04-4.17 (m, 2H), 3.47 (s,3H), 3.09-3.30 (m, 4H), 1.72 (t, J=7.2 Hz, 2H), 1.22-1.29 (m, 8H).ESI-MS (m/z): Calcd. for C24H25ClN2O3: 425.2 (M+1). found: 425.2.

Cpd 102: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.15-7.23 (m, J=8.6Hz, 2H), 7.04-7.10 (m, J=8.6 Hz, 2H), 7.00 (t, J=7.6 Hz, 1H), 6.87 (d,J=8.3 Hz, 1H), 4.27-4.37 (m, 2H), 3.48 (s, 3H), 3.20 (br. s., 2H), 3.10(s, 2H), 1.21 (d, J=6.1 Hz, 6H). ESI-MS (m/z): Calcd. for C23H23ClN2O3:411.1 (M+1). found: 411.1.

Cpd 103: ¹H NMR (CHLOROFORM-d) δ: 7.39 (dd, J=7.7, 1.6 Hz, 1H),7.30-7.37 (m, 1H), 7.16-7.23 (m, 2H), 7.04-7.09 (m, 2H), 6.98-7.04 (m,1H), 6.87 (d, J=8.3 Hz, 1H), 4.31 (dt, J=5.9, 4.5 Hz, 2H), 3.48 (s, 3H),3.24 (s, 2H), 3.06 (s, 2H), 1.22 (d, J=6.1 Hz, 6H). ESI-MS (m/z): Calcd.for C23H23ClN2O3: 411.1 (M+1). found: 411.1.

Cpd 107: ¹H NMR (CHLOROFORM-d) δ: 7.28-7.37 (m, 2H), 6.93-7.03 (m, 3H),6.89 (d, J=8.1 Hz, 1H), 6.56 (d, J=8.8 Hz, 2H), 3.53 (s, 3H), 3.11-3.22(m, 4H), 2.91 (s, 6H), 1.26-1.32 (m, 12H). ESI-MS (m/z): Calcd. forC27H33N3O3: 448.3 (M+1). found: 448.3.

Cpd 108: ¹H NMR (CHLOROFORM-d) δ: 8.02 (d, J=2.5 Hz, 1H), 7.29-7.39 (m,2H), 7.23 (dd, J=8.6, 2.5 Hz, 1H), 6.95-7.04 (m, 1H), 6.88 (d, J=7.6 Hz,1H), 6.55 (d, J=8.6 Hz, 1H), 4.30 (q, J=7.1 Hz, 2H), 3.53 (s, 3H),3.09-3.26 (m, 4H), 1.36 (t, J=7.1 Hz, 3H), 1.28 (d, J=6.3 Hz, 12H).ESI-MS (m/z): Calcd. for C26H31N3O4: 450.2 (M+1). found: 450.2.

Cpd 109: ¹H NMR (CHLOROFORM-d) δ: 8.36 (d, J=1.8 Hz, 1H), 7.29-7.41 (m,2H), 7.23 (dd, J=8.1, 2.3 Hz, 1H), 6.95-7.04 (m, 2H), 6.87 (d, J=8.1 Hz,1H), 3.50 (s, 3H), 3.12-3.27 (m, 4H), 2.50 (s, 3H), 1.29 (d, J=6.6 Hz,12H). ESI-MS (m/z): Calcd. for C25H29N3O3: 420.2 (M+1). found: 420.2.

Cpd 110: ¹H NMR (CHLOROFORM-d) δ: 8.09 (d, J=2.0 Hz, 1H), 7.28-7.36 (m,2H), 7.07 (dd, J=9.0, 2.4 Hz, 1H), 6.94-7.01 (m, 1H), 6.91 (d, J=8.6 Hz,1H), 6.32 (d, J=8.8 Hz, 1H), 3.58 (s, 3H), 3.18 (d, J=6.8 Hz, 4H), 3.05(s, 6H), 1.28 (d, J=6.6 Hz, 12H). ESI-MS (m/z): Calcd. for C26H32N4O3:449.3 (M+1). found: 449.3.

Cpd 111: ¹H NMR (CHLOROFORM-d) δ: 7.51 (d, J=8.1 Hz, 2H), 7.32-7.49 (m,2H), 7.21 (d, J=8.3 Hz, 2H), 7.05 (d, J=7.6 Hz, 1H), 6.87 (d, J=8.3 Hz,1H), 3.44 (s, 3H), 3.12-3.33 (m, 4H), 1.21-1.43 (m, 12H). ESI-MS (m/z):Calcd. for C26H27N3O3: 430.2 (M+1). found: 430.2.

Cpd 112: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.16-7.23 (m, 2H),7.04-7.10 (m, J=8.6 Hz, 2H), 6.97-7.04 (m, 1H), 6.87 (d, J=8.3 Hz, 1H),4.14-4.22 (m, 2H), 3.48 (s, 3H), 3.25 (br. s., 2H), 3.11 (s, 2H),1.75-1.85 (m, 4H), 1.50-1.60 (m, 2H), 1.27-1.40 (m, 2H). ESI-MS (m/z):Calcd. for C25H25ClN2O3: 437.2 (M+1). found: 437.2.

Cpd 114: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H),7.30-7.36 (m, 1H), 7.16-7.22 (m, 2H), 7.03-7.08 (m, 2H), 6.97-7.03 (m,1H), 6.84-6.89 (m, 1H), 4.70 (d, J=3.9 Hz, 2H), 3.47 (s, 3H), 3.27 (s,2H), 3.02 (s, 2H), 1.96 (dd, J=13.6, 6.2 Hz, 2H), 1.81 (tt, J=12.3, 6.0Hz, 2H), 1.61 (dt, J=12.3, 6.3 Hz, 1H), 1.38-1.54 (m, 1H). ESI-MS (m/z):Calcd. for C24H23ClN2O3: 423.1 (M+1). found: 423.1.

Cpd 115: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.16-7.22 (m, 2H),7.04-7.09 (m, 2H), 6.98-7.04 (m, 1H), 6.84-6.90 (m, 1H), 4.72 (d, J=4.4Hz, 2H), 3.48 (s, 3H), 3.16-3.28 (m, 2H), 3.06 (s, 2H), 1.95 (dd,J=13.7, 5.9 Hz, 2H), 1.78 (d, J=6.1 Hz, 1H), 1.61 (dt, J=12.2, 6.3 Hz,1H), 1.41-1.54 (m, 2H). ESI-MS (m/z): Calcd. for C24H23ClN2O3: 423.1(M+1). found: 423.1.

Cpd 120: ¹H NMR (CHLOROFORM-d) δ: 7.45 (t, J=8.0 Hz, 1H), 7.36 (d, J=7.4Hz, 1H), 7.05 (t, J=7.6 Hz, 1H), 7.00 (d, J=8.6 Hz, 1H), 6.71 (d, J=3.9Hz, 1H), 6.53 (d, J=3.9 Hz, 1H), 3.69 (s, 3H), 3.56-3.67 (m, 4H), 3.23(d, J=7.4 Hz, 4H), 1.09 (s, 3H), 1.00 (s, 3H). ESI-MS (m/z): Calcd. forC22H23ClN2O3S: 431.1 (M+1). found: 431.1.

Cpd 121: ¹H NMR (CHLOROFORM-d) δ: 7.41-7.51 (m, 1H), 7.35 (dd, J=7.8,1.7 Hz, 1H), 7.02-7.10 (m, 1H), 6.99 (d, J=8.3 Hz, 1H), 6.70 (d, J=3.9Hz, 1H), 6.50 (d, J=3.9 Hz, 1H), 3.68 (s, 3H), 3.18 (s, 4H), 1.30 (s,12H). ESI-MS (m/z): Calcd. for C23H25ClN2O3S: 445.1 (M+1). found: 445.1.

Example 21

To a solution of compound 35 (30 mg, 0.09 mmol, 1 eq) in DCM (2 mL) andacetic acid (0.01 mL) was added morpholine (16 mg, 0.18 mmol, 2 eq).After 30 min, sodium cyanoborohydride (22 mg, 0.35 mmol, 4 eq) was addedand the solution was stirred overnight. DCM was added, and the reactionmixture was washed sequentially with NaHCO₃ and water, dried over MgSO₄,filtered, and concentrated. Purification by column chromatography (8 g),eluting with 50 to 100% EA/hexanes to 2 to 5% MeOH/DCM+1% NH₃ gavecompound 68 (24.8 mg, 67%). ¹H NMR (CHLOROFORM-d) δ: 7.30-7.42 (m, 2H),7.17-7.24 (m, 2H), 7.04-7.10 (m, J=8.6 Hz, 2H), 7.01 (td, J=7.6, 1.1 Hz,1H), 6.88 (d, J=8.1 Hz, 1H), 3.79 (t, J=4.5 Hz, 4H), 3.59-3.71 (m, 1H),3.49 (s, 3H), 2.94-3.10 (m, 2H), 2.77-2.92 (m, 2H), 2.62 (br. s., 4H).ESI-MS (m/z): Calcd. for C23H24ClN3O2: 410.2 (M+1). found: 410.2.

Following the procedure described above for Example 21 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 117: ¹H NMR (CHLOROFORM-d) δ: 7.29-7.42 (m, 2H), 7.21 (d, J=8.3 Hz,2H), 7.07 (d, J=8.1 Hz, 2H), 7.01 (t, J=7.6 Hz, 1H), 6.88 (d, J=8.1 Hz,1H), 3.54-3.92 (m, 2H), 3.49 (s, 3H), 2.80-3.17 (m, 3H), 2.14-2.31 (m,2H), 1.73 (d, J=12.2 Hz, 2H), 1.31-1.54 (m, 3H), 0.97 (d, J=5.6 Hz, 3H).ESI-MS (m/z): Calcd. for C25H28ClN3O: 422.2 (M+1). found: 422.2.

Cpd 118: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.40 (m, 2H), 7.17-7.23 (m, 2H),7.04-7.09 (m, 2H), 7.01 (td, J=7.6, 1.1 Hz, 1H), 6.88 (d, J=7.6 Hz, 1H),3.81 (t, J=7.9 Hz, 1H), 3.49 (s, 3H), 2.92-3.12 (m, 6H), 2.74 (q, J=10.3Hz, 2H), 1.72 (t, J=7.0 Hz, 2H), 1.41-1.57 (m, 4H), 0.80-0.89 (m, 6H).ESI-MS (m/z): Calcd. for C27H32ClN3O: 450.2 (M+1). found: 450.2.

Cpd 119: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.6 Hz, 1H),7.30-7.36 (m, 1H), 7.16-7.23 (m, 2H), 7.04-7.10 (m, 2H), 6.97-7.04 (m,1H), 6.87 (d, J=7.3 Hz, 1H), 3.56 (t, J=7.9 Hz, 1H), 3.49 (s, 3H),2.90-3.05 (m, 2H), 2.79-2.90 (m, 2H), 2.69-2.79 (m, 2H), 2.47 (s, 2H),1.65 (t, J=6.8 Hz, 2H), 1.13 (s, 6H). ESI-MS (m/z): Calcd. forC25H28ClN3O: 422.2 (M+1). found: 422.2.

Cpd 123: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.42 (m, 2H), 7.17-7.25 (m, J=8.6Hz, 2H), 7.04-7.10 (m, J=8.6 Hz, 2H), 7.01 (td, J=7.6, 1.1 Hz, 1H), 6.88(d, J=8.3 Hz, 1H), 3.65 (quin, J=7.7 Hz, 1H), 3.49 (s, 3H), 2.92-3.13(m, 4H), 2.74-2.92 (m, 4H), 2.25-2.42 (m, 2H). ESI-MS (m/z): Calcd. forC23H22ClF2N3O: 430.1 (M+1). found: 430.1.

Example 22

A. To a suspension of compound 51 (50 mg, 0.15 mmol, 1 eq) in DCM (2 mL)was added cyclohexene (0.045 mL, 0.44 mmol, 3 eq),N-(phenylseleno)phthalimide (47 mg, 0.15 mmol, 1 eq) and BF₃-etherate(0.002 mL, 0.015 mmol, 0.1 eq). After 3 hrs, 1 N NaOH was added and thereaction mixture was extracted with DCM. The combined organic phase wasdried over MgSO₄, filtered, and concentrated. Purification by columnchromatography (12 g), eluting with 20 to 40% EA/hexanes, gave compound22a (40 mg, 47%, mix of diastereomers). ESI-MS (m/z): Calcd. forC31H31ClN2O2Se: 579.1 (M+1). found: 579.1.

B. To a solution of compound 22a (40 mg, 0.07 mmol, 1 eq) in benzene (2mL) was added Bu₃SnH (0.072 mL, 0.28 mmol, 4 eq) and AIBN (12 mg, 0.07mmol, 1 eq) and the reaction mixture was heated to 80° C. in a vialovernight. The solution was concentrated, and purification by columnchromatography (8 g), eluting with 7 to 15 to 20% EA/hexanes, gaveimpure compound 88. Further purification by HPLC eluting with 30 to 100%ACN/H₂O gave compound 88 in the desired purity (16 mg, 54%). ¹H NMR(CHLOROFORM-d) δ: 7.37 (dd, J=7.7, 1.6 Hz, 1H), 7.33 (td, J=7.9, 1.6 Hz,1H), 7.16-7.22 (m, 2H), 7.04-7.10 (m, 2H), 7.01 (td, J=7.6, 1.1 Hz, 1H),6.84-6.90 (m, 1H), 4.78-4.87 (m, 1H), 3.49 (s, 3H), 3.35-3.45 (m, 1H),3.10-3.23 (m, 2H), 2.75-2.90 (m, 2H), 1.97 (d, J=9.9 Hz, 2H), 1.74-1.81(m, 2H), 1.55-1.61 (m, 1H), 1.14-1.41 (m, 5H). ESI-MS (m/z): Calcd. forC25H27ClN2O2: 423.2 (M+1). found: 423.2.

Following the procedure described above for Example 22 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 89: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.8, 1.5 Hz, 1H), 7.30-7.37(m, 1H), 7.20 (d, J=8.1 Hz, 2H), 7.07 (dd, J=8.6, 1.8 Hz, 2H), 6.98-7.04(m, 1H), 6.88 (d, J=8.3 Hz, 1H), 4.68-4.78 (m, 1H), 3.54 (d, J=6.6 Hz,1H), 3.49 (s, 3H), 3.10-3.23 (m, 2H), 2.74-2.91 (m, 2H), 2.36 (d, J=4.3Hz, 1H), 2.26 (br. s., 1H), 1.39-1.68 (m, 5H), 0.98-1.16 (m, 3H). ESI-MS(m/z): Calcd. for C26H27ClN2O2: 435.2 (M+1). found: 435.2.

Cpd 90: ¹H NMR (CHLOROFORM-d) δ: 7.30-7.41 (m, 2H), 7.17-7.23 (m, 2H),7.05-7.10 (m, 2H), 6.99-7.04 (m, 1H), 6.88 (d, J=8.3 Hz, 1H), 4.68-4.77(m, 1H), 4.04-4.13 (m, 1H), 3.50 (s, 3H), 3.11-3.24 (m, 2H), 2.84 (ddd,J=21.9, 15.7, 5.7 Hz, 2H), 1.48-1.87 (m, 6H), 0.81-1.03 (m, 2H). ESI-MS(m/z): Calcd. for C24H25ClN2O2: 409.2 (M+1). found: 409.2.

Example 23

A. To a suspension of anhydrous CeCl₃ (36 mg, 0.15 mmol, 0.5 eq) in THF(5 mL) at rt under Argon was added compound 23a (100 mg, 0.3 mmol, 1 eq)followed by cyclohexylmethylmagnesium bromide (23b) (1.82 mL of a 0.5 Msolution in THF, 0.91 mmol, 3 eq). After stirring overnight, water and 1N HCl were added, the reaction mixture was extracted with ether, and theorganic phases were combined, dried over MgSO₄, filtered, andconcentrated. Purification by chromatography (12 g), eluting with 30 to60 to 100% EA/hexanes gave compound 23c (12 mg, 9%). ESI-MS (m/z):Calcd. for C27H29N3O2: 428.2 (M+1). found: 428.2.

B. To a solution of compound 23c (12 mg, 0.028 mmol, 1 eq) in THF (2 mL)at rt under Argon was added Burgess reagent (33 mg, 0.14 mmol, 5 eq).After 1 hr, water was added, extracted with DCM, the organics combined,dried over MgSO₄ and concentrated. Purification by chromatography (4 g),eluting with 15 to 30% EA/hexanes, gave compound 23d (3 mg, 26%, mix ofisomers). ESI-MS (m/z): Calcd. for C27H27N3O: 410.2 (M+1). found: 410.2.

C. A solution of compound 23d (3 mg) and 10% Pd/C (5 mg) in methanol (5mL) were placed under a hydrogen gas atmosphere overnight. The reactionwas filtered through diatomaceous earth and concentrated. Purificationby HPLC gave compound 106 (1.2 mg, 38%). ¹H NMR (CHLOROFORM-d) δ: 7.51(d, J=8.3 Hz, 2H), 7.42 (d, J=7.6 Hz, 1H), 7.33-7.39 (m, 1H), 7.24 (d,J=8.6 Hz, 2H), 7.04 (t, J=7.2 Hz, 1H), 6.88 (d, J=7.6 Hz, 1H), 3.46 (s,3H), 2.91-3.13 (m, 3H), 2.43-2.55 (m, 2H), 1.64-1.83 (m, 4H), 1.48-1.56(m, 3H), 1.13-1.32 (m, 4H), 0.80-1.00 (m, 2H). ESI-MS (m/z): Calcd. forC27H29N3O: 412.2 (M+1). found: 412.2.

Following the procedure described above for Example 23 and substitutingthe appropriate reagents, starting materials and purification methodsknown to those skilled in the art, the following compounds wereprepared:

Cpd 104: ¹H NMR (CHLOROFORM-d) δ: 7.38 (dd, J=7.7, 1.1 Hz, 1H), 7.33 (t,J=8.0 Hz, 1H), 7.16-7.22 (m, J=8.6 Hz, 2H), 7.05-7.11 (m, J=8.3 Hz, 2H),6.97-7.04 (m, 1H), 6.88 (d, J=8.3 Hz, 1H), 3.49 (s, 3H), 2.83-2.97 (m,2H), 2.48-2.73 (m, 3H), 1.74 (br. s., 5H), 1.44 (br. s., 1H), 1.15-1.35(m, 3H), 0.78-1.12 (m, 2H). ESI-MS (m/z): Calcd. for C25H27ClN2O: 407.2(M+1). found: 407.2.

Cpd 105: ¹H NMR (CHLOROFORM-d) δ: 7.51 (d, J=8.6 Hz, 2H), 7.42 (dd,J=7.7, 1.6 Hz, 1H), 7.33-7.39 (m, 1H), 7.24 (d, J=8.6 Hz, 2H), 7.00-7.08(m, 1H), 6.85-6.91 (m, 1H), 3.46 (s, 3H), 2.91-3.10 (m, 3H), 2.42-2.58(m, 2H), 1.66-1.78 (m, 1H), 1.47-1.56 (m, 2H), 0.96 (d, J=6.6 Hz, 6H).ESI-MS (m/z): Calcd. for C24H25N3O: 372.2 (M+1). found: 372.2.

The compounds of Table 1, exemplified hereinbelow, were preparedaccording to the schemes and specific examples described herein.

TABLE 1 Compounds of Formula (I) Formula (I)

Cpd Configuration No. R¹ R² R³ Q G at C-5 1 methoxy H H 4-chloro-hydroxyethyl RS phenyl 2 methoxy H H 4-chloro- 2-(morpholin-4-yl- RSphenyl carbonyloxy) ethyl 3 methoxy H H 4-chloro- 2-(dimethylamino- RSphenyl carbonyloxy)ethyl 4 methoxy H H 4-chloro- prop-2-en-1-yl RSphenyl 5 methoxy H H 4-chloro- ethoxycarbonyl RS phenyl 6 methoxy H H4-chloro- aminocarbonyl RS phenyl 7 methoxy H H phenyl methanesulfonyl-RS amino-methyl 8 methoxy H H 4-chloro- methanesulfonyl- RS phenylamino-methyl 9 methoxy H H phenyl cyano RS 10 methoxy H H 4-chloro-cyano RS phenyl 11 methoxy H H 4-chloro- 2-(methanesulfonyl- RS phenylamino)ethyl 12 methoxy H H 4-chloro- 2-(methylcarbonyl- RS phenylamino)ethyl 13 methoxy H H 4-chloro- 2-(t-butoxycarbonyl- RS phenylamino)ethyl 14 ethyl H H 4- ethoxycarbonyl RS chlorophenyl 15 ethyl H H4-chloro- phenyl

RS 16 ethyl H H 4-chloro- t-butoxycarbonyl- RS phenyl amino-methyl 17ethyl H H 4-chloro- diethylamino- RS phenyl carbonyloxy- methyl 18 ethylH H 4-chloro- methanesulfonyl- RS phenyl amino-methyl 19 ethyl H H4-chloro- trifluoromethyl- RS phenyl carbonylamino- methyl 20 trifluoro-H H 4-chloro- 2- RS methyl phenyl (t-butoxycarbonyl- amino)ethyl 21trifluoro- H H 4-chloro- 2-(methanesulfonyl- RS methyl phenylamino)ethyl 22 trifluoro- H H 4-chloro- 2-(dimethylamino- RS methylphenyl carbonylamino) ethyl 23 trifluoro- H H 4-chloro- dimethylamino-RS methoxy phenyl carbonyloxy 24 trifluoro- H H 4-chloro-morpholin-4-yl- RS methoxy phenyl carbonyloxy 25 trifluoro- H H4-chloro- hydroxy RS methoxy phenyl 26 methoxy H H 4-chloro- hydroxy RSphenyl 27 trifluoro- H H 4-chloro- oxo N/A methoxy phenyl 28 methoxy H H4-chloro- dimethylamino- RS phenyl carbonyloxy 29 methoxy H H 4-chloro-morpholin-4-yl- RS phenyl carbonyloxy 30 ethoxy H H 4-chloro-dimethylamino- RS phenyl carbonyloxy 31 ethoxy H H 4-chloro-morpholin-4-yl- RS phenyl carbonyloxy 32 methoxy H H 4-chloro-methanesulfonyl- RS phenyl amino 33 methoxy H H 4-chloro-isopropylsulfonyl- RS phenyl amino 34 methoxy H H 4-chloro-dimethylamino- RS phenyl carbonylamino 35 methoxy H H 4-chloro- oxo N/Aphenyl 36 ethoxy H H 4-chloro- oxo N/A phenyl 37 methoxy H H 4-chloro-methanesulfonyl-N- RS phenyl methyl-amino 38 ethoxy H H 4-chloro-2,5-dioxo- RS phenyl pyrrolidin-1-yl 39 ethoxy H H 4-chloro-1H-imidazol-1-yl RS phenyl 40 ethoxy H H 4-chloro- 2-oxo- RS phenylpyrrolidin-1-yl 41 ethoxy H H 4-chloro- 4-(trimethylsilyl)- RS phenyl1H-1,2,3-triazol-1- yl 42 ethoxy H H 4-chloro- 1H-1,2,3-triazol-1- RSphenyl yl 43 ethoxy H H 4-chloro- 1H-imidazol-1-yl R phenyl 44 ethoxy HH 4-chloro- isopropylsulfonyl- R phenyl amino 45 ethoxy H H 4-chloro-trifluoromethyl- R phenyl carbonylamino 46 ethoxy H H 4-chloro-dimethylamino- R phenyl sulfonyl-N-methyl- amino 47 ethoxy H H 4-chloro-dimethylamino- RS phenyl sulfonylamino 48 ethoxy H H 4-chloro-dimethylamino- RS phenyl sulfonyl-N-methyl- amino 49 methoxy H H4-chloro- methoxy R phenyl 50 R² taken with R¹ and H 4-chloro-dimethylamino- S the phenyl ring to phenyl sulfonyl-N-methyl- which R¹and R² are amino both attached to form 2,3-dihydro-1- benzofuran-7-yl 51R² taken with R¹ and H 4-chloro- isopropylsulfonyl- S the phenyl ring tophenyl N-methyl-amino which R¹ and R² are both attached to form2,3-dihydro-1- benzofuran-7-yl 52 methoxy H chloro 4-chloro- phenyl

spiro fused 53 methoxy H H 4-chloro- ═N(OH) N/A phenyl 54 methoxy H H4-chloro- phenyl

spiro fused 55 methoxy H H 4-chloro- phenyl

R 56 methoxy H H 6-methoxy- dimethylamino- R pyridin-3-ylsulfonyl-N-methyl- amino 57 methoxy H H 6-isopropyl- dimethylamino- Roxy sulfonyl-N-methyl- pyridin-3-yl amino 58 methoxy H H 4-chloro-phenyloxy S phenyl 59 methoxy H H 4-chloro- pyridin-3-yloxy S phenyl 60methoxy H H 4-chloro- 6-isopropyloxy- RS phenyl pyridin-3-yl 61 methoxyH H 4-chloro- pyridin-2-yloxy R phenyl 62 methoxy H H 4-chloro-6-(morpholin-4-yl) RS phenyl pyridin-3-yl 63 methoxy H H 4-chloro-pyridin-3-yl RS phenyl 64 methoxy H H 4-chloro- 4,4-dimethyl- RS phenylcyclohexyl 65 methoxy H H 4-chloro- (3-RS)-1,2,3,4- RS phenyltetrahydroquinolin- 3-yl 66 methoxy H H 4-chloro- 5-(ethoxycarbonyl) RSphenyl pyridin-3-yl 67 methoxy H H 4-chloro- isopropyloxy S phenyl 68methoxy H H 4-chloro- morpholin-4-yl RS phenyl 69 methoxy H H 4-chloro-trimethylsilyloxy S phenyl 70 methoxy H H 4-chloro- phenyl

S 71 methoxy H H 4-chloro- phenyl

spiro fused 72 methoxy H H 4-chloro- 2-ethylbutoxy S phenyl 73 methoxy HH 4-chloro- 6-methyl- RS phenyl pyridin-3-yl 74 methoxy H H 4-chloro-6-ethoxy- RS phenyl pyridin-3-yl 75 methoxy H H 4-chloro- 2-chloro-6- RSphenyl isopropyl- pyridin-3-yl 76 methoxy H H 4-chloro- tetrahydro-2H- Sphenyl pyran-2-yloxy 77 methoxy H H 4-chloro- 6-(cyclopropyl) RS phenylpyridin-3-yl 78 methoxy H H 4-chloro- cyclohexyl- S phenyl carbonyloxy79 methoxy H H 4-chloro- cyclopentyl- S phenyl carbonyloxy 80 methoxy HH 4-chloro- cyclobutyl- S phenyl carbonyloxy 81 methoxy H H 4-chloro-isopropyl- S phenyl carbonyloxy 82 methoxy H H 4-chloro- cyclohexyl- Sphenyl methyloxy 83 methoxy H H 4-chloro- cyclopentyl- S phenylmethyloxy 84 methoxy H H 4-chloro- cyclobutyl- S phenyl methyloxy 85methoxy H H 4-chloro- 2-methylpropyloxy S phenyl 86 methoxy H H4-chloro- tetrahydro-2H- S phenyl pyran-4- ylcarbonyloxy 87 methoxy H H4-chloro- tetrahydro-2H- S phenyl pyran-4-yl- methyloxy 88 methoxy H H4-chloro- cyclohexyloxy S phenyl 89 methoxy H H 4-chloro- (1S,2S,4R)- Sphenyl bicyclo[2.2.1]hept- 2-yloxy 90 methoxy H H 4-chloro-cyclopentyloxy S phenyl 91 methoxy H H 4-cyano phenyl

spiro fused 92 methoxy H H 4-chloro- isopropyl RS phenyl 93 methoxy H H4-dimethyl- amino- phenyl

spiro fused 94 methoxy H H 6-ethoxy- pyridin-3-yl

spiro fused 95 methoxy H H 6-methyl- pyridin-3-yl

spiro fused 96 methoxy H H 6-methoxy- pyridin-3-yl

spiro fused 97 methoxy H H 6-dimethyl- amino- pyridin-3-yl

spiro fused 98 methoxy H H 4-chloro- phenyl

spiro fused 99 methoxy H H 4-chloro- phenyl

spiro fused 100 methoxy H H 4-chloro- phenyl

spiro fused 101 methoxy H H 4-chloro- phenyl

spiro fused 102 methoxy H H 4-chloro- phenyl

spiro fused 103 methoxy H H 4-chloro- phenyl

spiro fused 104 methoxy H H 4-chloro- cyclohexyl RS phenyl 105 methoxy HH 4-cyano- 2-methylpropyl RS phenyl 106 methoxy H H 4-cyano-cyclohexylmethyl RS phenyl 107 methoxy H H 4-dimethyl- amino- phenyl

spiro fused 108 methoxy H H 6-ethoxy- pyridin-3-yl

spiro fused 109 methoxy H H 6-methyl- pyridin-3-yl

spiro fused 110 methoxy H H 6-dimethyl- amino- pyridin-3-yl

spiro fused 111 methoxy H H 4-cyano- phenyl

spiro fused 112 methoxy H H 4-chloro- phenyl

spiro fused 113 methoxy H H 4-chloro- phenyl

spiro fused 114 methoxy H H 4-chloro- phenyl

spiro fused 115 methoxy H H 4-chloro- phenyl

spiro fused 116 methoxy H H 4-chloro- 2,6-dimethyl- RS phenylmorpholin-4-yl 117 methoxy H H 4-chloro- 4-methyl- RS phenylpiperidin-1-yl 118 methoxy H H 4-chloro- 3,3-diethyl- RS phenylpyrrolidin-1-yl 119 methoxy H H 4-chloro- 3,3-dimethyl- RS phenylpyrrolidin-1-yl 120 methoxy H H 5-chloro- thien-2-yl

spiro fused 121 methoxy H H 5-chloro- thien-2-yl

spiro fused 122 methoxy H H 4-chloro- pyrrolidin-1-yl RS phenyl 123methoxy H H 4-chloro- 3,3-difluoro- RS phenyl pyrrolidin-1-yl 124methoxy H H 4-cyano- 4-cyclopentyl-1H- S phenyl 1,2,3-triazol-1-yl 125methoxy H H 4-cyano- 4- S phenyl methoxycarbonyl- 1H-1,2,3-triazol-1- yl126 methoxy H H 4-cyano- 4-(1-hydroxy-1- S phenyl methylethyl)-1H-1,2,3-triazol-1-yl 127 methoxy H H 4-cyano- 4-(2-methyl- S phenylpropyl)-1H-1,2,3- triazol-1-yl 128 methoxy H H 4-cyano- 4- S phenyl(methylcarbonyloxy- methyl)-1H-1,2,3- triazol-1-yl 129 methoxy H H4-cyano- 4- S phenyl (methoxymethyl)- 1H-1,2,3-triazol-1- yl 130 methoxyH H 4-cyano- 4-t-butyl-1H-1,2,3- S phenyl triazol-1-yl 131 methoxy H H4-cyano- 4,5-dimethyl-1H- S phenyl imidazol-1-yl 132 methoxy H H4-cyano- 2,4,5-trimethyl-1H- S phenyl imidazol-1-yl 133 methoxy H H4-cyano- 2-ethyl-4,5- S phenyl dimethyl-1H- imidazol-1-yl 134 methoxy HH 4-cyano- 2-ethyl-1H- S phenyl imidazol-1-yl 135 methoxy H H 4-cyano-2-methyl-1H- S phenyl imidazol-1-yl 136 methoxy H H 4-cyano-4,5-diethyl-1H- S phenyl 1,2,3-triazol-1-yl 137 methoxy H H 4-cyano-2,4,5-triethyl-1H- S phenyl imidazol-1-yl 138 methoxy H H 4-cyano-2-methyl-4,5- S phenyl diethyl-1H- imidazol-1-yl 139 methoxy H H4-cyano- 4,5-diethyl-1H- S phenyl imidazol-1-yl

BIOLOGICAL EXAMPLES In Vitro Assays Example 1 Functional Assay:Antagonism of N-Type Calcium Channel

A stable cell line (HEK parent) co-expressing the α_(1B) (Cav2.2), β₃and α₂δ subunits of the N-type calcium channel subunits was used. Thesecells were routinely grown as monolayers in low glucose-containingDulbecco's Modified Eagle Medium supplemented with 10% FBS, 2 mML-glutamine, 100 I.U./mL penicillin, 100 μg/mL streptomycin, 400 μg/mLG418 and 200 μg/mL Zeocin (split ratio=1:5). Cells were maintained in 5%CO₂ at 37° C. Compounds of Formula (I) were prepared as 10 mM stocks inDMSO from neat compound, if available. Otherwise, the 5 or 10 mM DMSOstock solutions provided in-house were used.

Calcium mobilization responses to KCl depolarization were evaluated bymeasuring the intensity of calcium-mediated fluorescent signal in thepresence of BD Calcium Assay Dye (BD Biosciences, Franklin Lakes, N.J.,U.S.A.), utilizing a Functional Drug Screening System (FDSS) byHamamatsu Corporation (Bridgewater, N.J. U.S.A.).

Twenty-four hr prior to assay, cells were seeded in clear-basepoly-D-lysine-coated 384-well plates (BD Biosciences) at a density of5,000 cells per well in culture medium and grown overnight in 5% CO₂ at37° C. On the day of assay, growth media were removed, and cells wereloaded with BD calcium assay dye (BD Biosciences) for 35 min at 37° C.under 5% CO₂ and then for 25 min at room temp. Utilizing the FDSS, cellswere exposed to representative compounds of Formula (I) at varyingconcentrations, and intracellular calcium was measured for 5 min priorto the addition of 50 mM KCl for an additional 3 min of measurement.

Calculations and Formulas

IC₅₀ values for representative compounds of Formula (I) were determinedfrom six-point concentration-response experiments and represent theconcentration of said compound required to inhibit 50% of the maximalresponse. Maximal fluorescence intensity (FI) achieved upon addition of50 mM KCl was exported from the FDSS software and further analyzed usingGraphPad Prism 3.02 (Graph Pad Software Inc., San Diego, Calif.,U.S.A.). Data were normalized to the maximum average counts fromquadruplicate wells for each condition in the presence of 50 mM KCl andto the minimum average counts in the presence of buffer. Theoreticalcurves were generated using nonlinear regression curve-fitting analysisof either sigmoidal concentration-response or sigmoidalconcentration-response (variable slope), and the IC₅₀ values with thebest-fit curve determined by GraphPad Prism were reported. Resultantdata are shown in Table 2.

TABLE 2 % Inhibition % Inhibition Compound FDSS IC₅₀ (%) (%) No (μM) at0.33 μM at 1 μM 1 0.20 2 0.033 3 0.026 4 81 5 0.043 6 0.49 75 7 68 80.055 96 9 59 10 0.30 83 11 0.073 99 12 0.070 13 0.038 14 0.090 15 0.3016 0.13 17 0.18 18 0.20 19 0.13 20 0.26 21 65 22 0.22 23 0.14 24 0.15 2561 26 62 27 0.011 28 0.015 29 0.043 30 0.028 31 0.018 32 0.026 33 0.01834 0.014 35 0.059 36 0.029 37 0.0064 38 0.0075 39 0.038 81 40 0.019 410.024 92 42 0.019 91 43 0.042 87 44 0.032 89 45 0.0040 94 46 0.0026 9947 0.0040 92 48 0.0012 97 49 0.052 76 50 0.014 95 51 0.034 94 52 0.13 6453 31 54 0.050 86 55 0.011 95 56 0.013 93 57 0.018 99 58 0.13 65 590.094 76 60 0.28 62 61 0.098 77 62 42 63 0.0086 98 64 0.28 66 65 0.28 5966 0.066 79 67 0.0057 100 68 0.016 95 69 0.0096 93 70 0.015 96 71 0.01389 72 0.061 78 73 0.086 81 74 0.15 61 75 0.23 53 76 0.028 92 77 0.062 8178 0.093 78 79 0.075 82 80 0.031 89 81 0.048 86 82 0.13 76 83 0.049 9284 0.06 80 85 0.023 94 86 0.082 82 87 0.092 82 88 0.043 83 89 0.049 8590 0.022 89 91 0.019 89 92 43 93 0.012 91 94 0.060 81 95 0.11 67 960.034 81 97 0.029 88 98 0.0059 102 99 0.013 93 100 0.0044 101 101 0.02798 102 0.0076 97 103 0.0048 101 104 0.14 61 105 0.046 81 106 0.27 64 1070.0030 92 108 0.010 86 109 0.019 84 110 0.0028 90 111 0.0037 90 1120.018 90 113 0.042 82 114 0.0050 90 115 0.011 85 116 0.048 77 117 0.04475 118 0.046 76 119 0.084 76 120 0.091 78 121 0.030 86 122 33 123 0.01991 124 0.043 88 125 0.081 70 126 33 127 0.017 97 128 0.17 59 129 47 1300.050 92 131 0.1045 67 132 29 133 35 134 0.20 50 135 44 136 0.016 89 13749 138 0.32 63 139 0.037 87

Example 2 Automated Electrophysiology Assay

Cells were grown in T175 flasks to 50%-90% confluence. At the time ofuse, cells were enzymatically treated with Detachin (Genlantis, SanDiego, Calif. USA), centrifuged, rinsed, and resuspended in 293 SFM IImedia (Life Technologies, Grand Island, N.Y. U.S.A.) supplemented with25 mM HEPES (Sigma-Aldrich, St. Louis, Mo. U.S.A.) to a concentration of2-3×10⁶ cells/mL. Cells were added to the automated cell preparationstation on the QPatch-HT (Sophion Biosciences, North Brunswick, N.J.U.S.A.), and following a 10- to 30-min recovery period with gentlestirring, the assay protocol was initiated. During the automated cellpreparation, cells were collected, centrifuged and resuspended in anextracellular (EC) solution containing 132 mM NaCl, 1.8 mM CaCl₂, 5.4 mMKCl, 0.8 mM MgCl₂, 10 mM glucose, and 10 mM HEPES (pH=7.4), adjustedwith sucrose to approximately 315 m0sm. The QPlate was primed with anintracellular solution containing 135 mM CsCl, 10 mM EGTA, 4 MgATP, 0.3NaGTP, and 20 mM HEPES (pH=7.2), adjusted to approximately 290 m0sm withdeionized water and the EC solution. Cells were added to the preparedQPlate wells by robotic pipettes of the QPatch-HT.

For cells determined to be in stable whole-cell patch clamp, the ECsolution was replaced with a barium (Ba)/triethylammonium (TEA) solutioncontaining 140 mM TEA-Cl, 10 mM BaCl₂, 0.8 mM MgCl₂, 10 mM glucose and10 mM HEPES (pH=7.4). High (40 mM) BaCl₂ concentrations were made withadjustments to TEA-Cl (90 mM) to maintain the osmolarity. From a restingpotential of −80 mV, a train of depolarizing pulses (15 pulses at 5 Hz,+20 mV) was delivered to the cell once every 30 sec for eight trains (4min total), and the resulting currents were measured during a controlperiod (no compound). This protocol was repeated for each subsequentaddition of control buffer with or without compound (three periodstotal, each with four trains). The current generated in the 1^(st) and15^(th) pulses of the last train of each period in the presence of eachdrug concentration was normalized to the current generated during thecontrol period at the respective pulses (representing low- andhigh-frequency stimulation, respectively). Data from both the second andthird drug application periods were analyzed for each cell. A finaladdition of Ba/TEA solution containing 60-100 μM CdCl₂ was made to blockall N-type current and to “zero” the currents for each cell. Allbuffer/compound additions were made using a “spitting” feature of theQPatch-HT, which added three repetitions of 5 μL solution at thebeginning of each recording period.

To examine closed-state inactivation, cells were subjected to achannel-activating 50-msec depolarizing step pulse from −80 to +10 mV,followed by a 5-sec nonactivating step to voltages ranging from −130 to−60 mV in 10 mV increments and then a 50-ms step from −80 to +10 mV toassess the remaining current. Currents from the activating voltage pulsewere normalized to the peak value of the test pulse following the −130mV step and fit to a Boltzman equation to obtain the V_(1/2).Roscovitine (Sigma-Aldrich) was prepared as a 100 mM stock in dimethylsulfoxide and diluted to the indicated working concentrations.Tetrandrine (Sigma-Aldrich) was prepared as a 4 mM stock in acidic water(pH=2.0) and then diluted to working concentrations in the externalsolution. ω-Conotoxin MVIIA (Sigma-Aldrich) was prepared as a 0.3 mg/mLstock solution in water, with 0.1% bovine serum albumin V (LifeTechnologies). Compounds of Formula (I) were diluted first into dimethylsulfoxide and then into 10% pluronic F-127 in water (Life Technologies),sonicated for 1 min and diluted into EC buffer. Vehicle controls wererun in parallel in all experiments.

Unless otherwise indicated, statistics for comparing amongelectrophysiological results utilized a one-way analysis of variancewith Fisher's least squares determination test for pair-wise comparison.Resultant data are shown in Tables 3 and 4, below.

TABLE 3 QPatch at Low Frequency % Inhibition at Various Concentrations(μM) Cpd No. 0.01 0.03 0.1 0.25 1 5 2 54 76 90 3 35 69 93 5 82 8 −9 6211 29 12 15 13 42 16 19 27 −16 28 25 29 −8 30 9 31 14 32 18 33 35 34 3436 18 37 44 38 47 39 13 34 51 41 58 42 86 43 −22 44 42 45 60 46 21 47 1548 52 50 33 51 49 54 55 55 15 12 57 56 −1 32 57 75 63 40 67 48 68 33 6915 71 21 76 27 78 15 79 −7 80 7 6 81 −4 85 −5 88 22 89 6 90 10 91 19 2840 93 12 96 −1 97 27 98 −6 99 −4 100 10 46 72 101 3 102 42 103 −21 12 36105 −1 10 107 34 108 3 109 8 110 −9 111 −5 112 7 113 −4 114 44 115 8 1232 124 68 127 13 130 39 139 72

TABLE 4 QPatch at High Frequency % Inhibition at Various Concentrations(μM) Cpd No. 0.01 0.03 0.1 0.25 1 5 2 58 69 97 3 57 76 88 5 85 8 −12 5711 28 12 26 13 67 16 43 27 −14 28 45 29 21 30 25 31 22 32 20 33 42 34 3736 26 37 46 38 53 39 29 47 72 41 60 42 87 43 5 44 48 45 68 46 50 47 1948 63 50 41 51 66 54 67 55 19 29 79 56 2 47 57 83 63 62 67 61 68 31 6926 70 19 71 37 76 42 78 27 79 11 80 22 43 81 12 85 2 88 33 89 26 90 2191 20 39 61 93 30 96 20 97 33 98 28 99 34 100 21 69 83 101 40 102 58 10346 69 105 20 40 107 33 108 13 109 9 110 1 111 21 112 26 113 3 114 65 11537 123 26 124 73 127 26 130 57 139 66

In Vivo Assays Example 3 Complete Freund's Adjuvant (CFA)-InducedHyperalgesia

The intraplantar injection of complete Freund's adjuvant (CFA) inrodents results in a long-lasting inflammatory reaction, characterizedby a pronounced hypersensitivity to both thermal and mechanical stimuli,which peaks between 24-72 hr following injection and can last forseveral weeks. This test predicts the analgesic, anti-allodynic and/orantihyperalgesic effect of numerous efficacious clinical agents,including acetaminophen, NSAIDS, such as aspirin and ibuprofen, opioids,such as morphine, and especially the N-type calcium channel blockerziconotide, which is marketed as Prialt® for the management of severechronic pain, including several types of neuropathic pain.

To assess whether test compounds of Formula (I) reverse establishedhypersensitivity, a 100 μL of CFA (suspended in a 1:1 emulsion of salineand heat-killed Mycobacterium tuberculosis in mineral oil) was injectedinto a single hind paw of Sprague-Dawley rats (typically males rangingfrom 150-350 g).

Each rat was placed in a test chamber on a warm glass surface andallowed to acclimate for approximately 10 min. A radiant thermalstimulus (beam of light) was then focused through the glass onto theplantar surface of each hind paw in turn. The thermal stimulus wasautomatically shut off by a photoelectric relay when the paw was movedor when the cut-off time was reached (20 sec for radiant heat at ˜5Amps). An initial (baseline) response latency to the thermal stimuluswas recorded for each animal prior to the injection of CFA. Twenty-fourhr following intraplantar CFA injection, the response latency of theanimal to the thermal stimulus was then re-evaluated and compared to theanimal's baseline response time. Only rats that exhibited at least a 25%reduction in response latency (i.e., hyperalgesia) were included infurther analysis. Immediately following the post-CFA latency assessment,test compound or vehicle (usually Solutol, hydroxypropylmethylcellulose, hydroxypropyl beta-cyclodextrin or PEG-400) wasadministered i.p. or p.o. to rats. Post-compound treatment withdrawallatencies were assessed at fixed time intervals, typically 30, 60 and120 min. Resultant data for Compound 71 of Formula (I) is shown in FIG.1.

While the foregoing specification teaches the principles of the presentinvention, with examples provided for the purpose of illustration, itwill be understood that the practice of the invention encompasses all ofthe usual variations, adaptations and/or modifications as come withinthe scope of the following claims and their equivalents.

We claim:
 1. A compound of Formula (I)

wherein R¹ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, trifluoromethoxy, and trifluoromethyl; R² is hydrogen; or,R² may be taken with R¹ and the phenyl ring to which R¹ and R² are bothattached to form 2,3-dihydrobenzofuran-7-yl; R³ is hydrogen, chloro, orfluoro; Q is selected from the group consisting of Q1, Q2, and Q3;

wherein R⁴ is selected from the group consisting of hydrogen, C₁₋₄alkyl,C₁₋₄alkoxy, cyano, fluoro, chloro, hydroxy, di(C₁₋₄alkyl)amino,(C₁₋₄alkyl)amino, amino, C₁₋₄alkylcarbonyl, and C₁₋₄alkylsulfonyl; R⁵and R⁶ are each independently selected from the group consisting ofhydrogen, C₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino;G is selected from the group consisting of C₁₋₆alkyl,hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, hydroxy, allyl, 2-methylprop-1-enyl,cyano, oxime, phenoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl,4,4-dimethyl-cyclohexyl, C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy,C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl,pyrrolidin-1-yl, pyridinyloxy, trimethylsilyloxy, oxo,(tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 6-(morpholin-4-yl)-pyrimidin-3-yl,4-methyl-piperidin-1-yl, (1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-ylcarbonyloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl, pyridin-3-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl, morpholin-4-yl, andC₁₋₄alkoxycarbonyl; 1H-1,2,3-triazol-1-yl optionally substituted withone to two substituents each independently selected from the groupconsisting of C₁₋₄alkyl, 2-hydroxypropan-2-yl, methoxymethyl,C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl, C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, andtrimethylsilyl; 1H-imidazol-1-yl optionally independently substitutedwith one to three C₁₋₃alkyl substituents; and a spirofused heterocyclylindependently selected from the group consisting of4,4,5,5-tetramethyl-1,3-dioxolan-2-yl, 4,5-dimethyl-1,3-dioxolan-2-yl,1,3-dioxan-2-yl, 4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl; provided that a compound ofFormula (I) is other thanN-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;or3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];or an enantiomer, diastereomer, or pharmaceutically acceptable saltthereof.
 2. The compound of claim 1 wherein R¹ is selected from thegroup consisting of C₁₋₄alkyl, C₁₋₄alkoxy, and trifluoromethoxy.
 3. Thecompound of claim 2 wherein R¹ is selected from the group consisting ofC₁₋₄alkoxy, and trifluoromethoxy.
 4. The compound of claim 1 wherein R²is hydrogen.
 5. The compound of claim 1 wherein R³ is hydrogen orchloro.
 6. The compound of claim 5 wherein R³ is hydrogen.
 7. Thecompound of claim 1 wherein R⁴ is selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino.
 8. Thecompound of claim 1 wherein R⁶ is chloro.
 9. The compound of claim 1wherein G is selected from the group consisting of C₁₋₆alkyl,hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy, 2-methylprop-1-enyl, cyano, phenoxy,C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl, 4,4-dimethyl-cyclohexyl,C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl, pyridin-3-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl, and C₁₋₄alkoxycarbonyl;1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl,C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl; 1H-imidazol-1-yloptionally independently substituted with one to three C₁₋₃alkylsubstituents; and a spirofused heterocyclyl independently selected fromthe group consisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl.
 10. The compound of claim 9wherein G is selected from the group consisting of C₁₋₆alkyl,C₁₋₆alkoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,trifluoromethylcarbonylamino, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, pyridin-3-yl optionallysubstituted with a substituent independently selected from the groupconsisting of C₁₋₄alkyl, cyclopropyl, and C₁₋₄alkoxycarbonyl;1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl, and trimethylsilyl;1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents; and a spirofused heterocyclyl independentlyselected from the group consisting of4,4,5,5-tetramethyl-1,3-dioxolan-2-yl, 4,5-dimethyl-1,3-dioxolan-2-yl,1,3-dioxan-2-yl, 4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl.
 11. The compound of Formula(I) as in claim 1

wherein R¹ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, and trifluoromethoxy; R² is hydrogen; or, R² may be takenwith R¹ and the phenyl ring to which R¹ and R² are both attached to form2,3-dihydrobenzofuran-7-yl; R³ is hydrogen or chloro; Q is selected fromthe group consisting of Q1, Q2, and Q3;

wherein R⁴ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino; R⁵ and R⁶ are eachindependently selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino; G is selected fromthe group consisting of C₁₋₆alkyl, hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy,2-methylprop-1-enyl, cyano, phenoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl,4,4-dimethyl-cyclohexyl, C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy,C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl, pyridin-3-yl optionally substituted with morpholin-4-ylor one to two substituents each independently selected from the groupconsisting of C₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl, andC₁₋₄alkoxycarbonyl; 1H-1,2,3-triazol-1-yl optionally substituted withone to two substituents each independently selected from the groupconsisting of C₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl,C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl; 1H-imidazol-1-yloptionally independently substituted with one to three C₁₋₃alkylsubstituents; and a spirofused heterocyclyl independently selected fromthe group consisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl; provided that a compound ofFormula (I) is other thanN-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;or3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];or an enantiomer, diastereomer, or pharmaceutically acceptable saltthereof.
 12. The compound of Formula (I) as in claim 1

wherein R¹ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, and trifluoromethoxy; R² is hydrogen; or, R² may be takenwith R¹ and the phenyl ring to which R¹ and R² are both attached to form2,3-dihydrobenzofuran-7-yl; R³ is hydrogen; Q is selected from the groupconsisting of Q1, Q2, and Q3;

wherein R⁴ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino; R⁵ is selected fromthe group consisting of C₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, anddi(C₁₋₄alkyl)amino; R⁶ is chloro; G is selected from the groupconsisting of C₁₋₆alkyl, hydroxy(C₁₋₄)alkyl, C₁₋₆alkoxy,2-methylprop-1-enyl, cyano, phenoxy, C₁₋₄alkoxycarbonyl, C₃₋₆cycloalkyl,4,4-dimethyl-cyclohexyl, C₃₋₆cycloalkyl(C₁₋₄)alkyl, C₃₋₆cycloalkyloxy,C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄-alkylcarbonylamino-C₁₋₄alkyl,di(C₁₋₄alkyl)aminocarbonylamino-C₁₋₄alkyl, trifluoromethylcarbonylamino,trifluoromethylcarbonylamino-C₁₋₄alkyl, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, 1,2,3,4-tetrahydroquinolin-3-yl,aminocarbonyl, pyridin-3-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₁₋₄alkoxy, chloro, cyclopropyl, and C₁₋₄alkoxycarbonyl;1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl,C₁₋₄alkylcarbonyloxy-C₁₋₄alkyl, and trimethylsilyl; 1H-imidazol-1-yloptionally independently substituted with one to three C₁₋₃alkylsubstituents; and a spirofused heterocyclyl independently selected fromthe group consisting of 4,4,5,5-tetramethyl-1,3-dioxolan-2-yl,4,5-dimethyl-1,3-dioxolan-2-yl, 1,3-dioxan-2-yl,4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl; provided that a compound ofFormula (I) is other thanN-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;or3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];or an enantiomer, diastereomer, or pharmaceutically acceptable saltthereof.
 13. The compound of Formula (I) as in claim 1

wherein R¹ is selected from the group consisting of C₁₋₄alkoxy andtrifluoromethoxy; R² is hydrogen; R³ is hydrogen; Q is selected from thegroup consisting of Q1, Q2, and Q3;

wherein R⁴ is selected from the group consisting of C₁₋₄alkyl,C₁₋₄alkoxy, cyano, chloro, and di(C₁₋₄alkyl)amino; R⁵ is selected fromthe group consisting of C₁₋₄alkyl, C₁₋₄alkoxy, cyano, chloro, anddi(C₁₋₄alkyl)amino; R⁶ is chloro; G is selected from the groupconsisting of C₁₋₆alkyl, C₁₋₆alkoxy, C₁₋₄alkoxycarbonyl,C₃₋₆cycloalkyloxy, C₁₋₆alkylcarbonyloxy, di(C₁₋₄alkyl)aminocarbonyloxy,di(C₁₋₄alkyl)aminocarbonyloxy-C₁₋₄alkyl,C₁₋₄alkoxycarbonylamino-C₁₋₄alkyl, C₃₋₆cycloalkyl(C₁₋₄)alkoxy,C₃₋₆cycloalkylcarbonyloxy, di(C₁₋₄alkyl)aminosulfonyl-amino,di(C₁₋₄alkyl)aminosulfonyl-(N-methyl)amino,C₁₋₄alkylsulfonyl-(N-methyl)amino, C₁₋₄alkylsulfonylamino,C₁₋₄alkylsulfonylamino-C₁₋₄alkyl, C₁₋₄alkylcarbonylamino-C₁₋₄alkyl,trifluoromethylcarbonylamino, 2,5-dioxo-pyrrolidin-1-yl,2-oxo-pyrrolidin-1-yl, 3,3-difluoro-pyrrolidin-1-yl,3,3-diethyl-pyrrolidin-1-yl, 3,3-dimethyl-pyrrolidin-1-yl, pyridinyloxy,trimethylsilyloxy, oxo, (tetrahydro-2H-pyran-2-yl)oxy, morpholin-4-yl,2,6-dimethyl-morpholin-4-yl, morpholin-4-ylcarbonyloxy,morpholin-4-ylcarbonyloxy-C₁₋₄alkyl, 4-methyl-piperidin-1-yl,(1,2,4)-bicyclo[2.2.1]heptan-2-yloxy,tetrahydro-2H-pyran-4-yl(C₁₋₄)alkoxy, pyridin-3-yl optionallysubstituted with a substituent independently selected from the groupconsisting of C₁₋₄alkyl, cyclopropyl, and C₁₋₄alkoxycarbonyl;1H-1,2,3-triazol-1-yl optionally substituted with one to twosubstituents each independently selected from the group consisting ofC₁₋₄alkyl, C₃₋₆cycloalkyl, C₁₋₄alkoxycarbonyl, and trimethylsilyl;1H-imidazol-1-yl optionally independently substituted with one to threeC₁₋₃alkyl substituents; and a spirofused heterocyclyl independentlyselected from the group consisting of4,4,5,5-tetramethyl-1,3-dioxolan-2-yl, 4,5-dimethyl-1,3-dioxolan-2-yl,1,3-dioxan-2-yl, 4,6-dimethyl-1,3-dioxan-2-yl,(3a,6a)-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-2-yl,5,5-dimethyl-1,3-dioxan-2-yl, and(3a,7a)-hexahydrobenzo[d][1,3]dioxol-2-yl; provided that a compound ofFormula (I) is other thanN-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;or3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];or an enantiomer, diastereomer, or pharmaceutically acceptable saltthereof.
 14. The compound of Formula (I) as in claim 1

selected from the group consisting of2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethanol;2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethylmorpholine-4-carboxylate;2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyldimethylcarbamate;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-prop-2-en-1-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;ethyl3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxylate;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxamide;N-{[2-(2-methoxyphenyl)-3-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;N-{[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;2-(2-methoxyphenyl)-3-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carbonitrile;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carbonitrile;N-{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}methanesulfonamide;N-{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}acetamide;tert-butyl{2-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]ethyl}carbamate;ethyl3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-5-carboxylate;tert-butyl{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methylidene}carbamate;tert-butyl{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}carbamate;[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyldiethylcarbamate;N-{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}methanesulfonamide;N-{[3-(4-chlorophenyl)-2-(2-ethylphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methyl}-2,2,2-trifluoroacetamide;tert-butyl(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)carbamate;N-(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)methanesulfonamide;3-(2-{3-(4-chlorophenyl)-2-[2-(trifluoromethyl)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}ethyl)-1,1-dimethylurea;3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yldimethylcarbamate;3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylmorpholine-4-carboxylate;3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ol;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ol;3-(4-chlorophenyl)-2-[2-(trifluoromethoxy)phenyl]-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yldimethylcarbamate;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylmorpholine-4-carboxylate;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yldimethylcarbamate;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylmorpholine-4-carboxylate;N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]methanesulfonamide;N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]propane-2-sulfonamide;N′-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N-dimethylsulfamide;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-one;N-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N-methylmethanesulfonamide;1-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyrrolidine-2,5-dione;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;1-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyrrolidin-2-one;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-[4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-1,2,3-triazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-5-(1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]propane-2-sulfonamide;N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-2,2,2-trifluoroacetamide;N-[(5R)-3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;N′-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N-dimethylsulfamide;N-[3-(4-chlorophenyl)-2-(2-ethoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;(5R)-3-(4-chlorophenyl)-5-methoxy-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;N-[(5S)-3-(4-chlorophenyl)-2-(2,3-dihydro-1-benzofuran-7-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;N-[(5S)-3-(4-chlorophenyl)-2-(2,3-dihydro-1-benzofuran-7-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N-methylpropane-2-sulfonamide;2-(4-Chloro-2-methoxyphenyl)-3-(4-chlorophenyl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];(5Z)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydrocyclopenta[c]pyrazol-5(4H)-oneoxime;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];(5R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl2-ethylbutanoate;N-[(5R)-2-(2-Methoxyphenyl)-3-(6-methoxypyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-N,N′,N′-trimethylsulfamide;N-{(5R)-2-(2-Methoxyphenyl)-3-[6-(1-methylethoxy)pyridin-3-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl}-N,N′,N′-trimethylsulfamide;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-phenoxy-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(pyridin-3-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-[6-(1-methylethoxy)pyridin-3-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(pyridin-2-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(6-morpholin-4-ylpyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-pyridin-3-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-5-(4,4-dimethylcyclohexyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1,2,3,4-tetrahydroquinoline;Ethyl5-[3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]pyridine-3-carboxylate;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(1-methylethoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-morpholin-4-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-[(trimethylsilyl)oxy]-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl2-ethylbutanoate;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];(5S)-3-(4-chlorophenyl)-5-(2-ethylbutoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(6-methylpyridin-3-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-5-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;5-[2-Chloro-6-(1-methylethyl)pyridin-3-yl]-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(tetrahydro-2H-pyran-2-yloxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole3-(4-chlorophenyl)-5-(6-cyclopropylpyridin-3-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylcyclohexanecarboxylate;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylcyclopentanecarboxylate;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-ylcyclobutanecarboxylate;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl2-methylpropanoate;(5S)-3-(4-chlorophenyl)-5-(cyclohexylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-5-(cyclopentylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-5-(cyclobutylmethoxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(2-methylpropoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yltetrahydro-2H-pyran-4-carboxylate;(5S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-5-(cyclohexyloxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-5-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;(5S)-3-(4-chlorophenyl)-5-(cyclopentyloxy)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;4-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]benzonitrile;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(1-methylethyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;4-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]-N,N-dimethylaniline;3-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];2-(2-methoxyphenyl)-5′,5′-dimethyl-3-(6-methylpyridin-3-yl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];2-(2-methoxyphenyl)-3-(6-methoxypyridin-3-yl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];5-[2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxan]-3-yl]-N,N-dimethylpyridin-2-amine;(4′R,5′R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];(4′S,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];(4′R,6′R)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,6′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];(4′S,6′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,6′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];(4′R,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];(4′R,5′S)-3-(4-chlorophenyl)-2-(2-methoxyphenyl)-4′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];3-(4-chlorophenyl)-5-cyclohexyl-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;4-[2-(2-methoxyphenyl)-5-(2-methylpropyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[5-(cyclohexylmethyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]-N,N-dimethylaniline;3-(6-ethoxypyridin-3-yl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-3-(6-methylpyridin-3-yl)-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];5-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]-N,N-dimethylpyridin-2-amine;4-[2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolan]-3-yl]benzonitrile;(3aR,7aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,3a,4,5,6,6′,7,7a-octahydro-4′H-spiro[1,3-benzodioxole-2,5′-cyclopenta[c]pyrazole];(3aS,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];(3aR,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];(3aR,6aS)-3′-(4-chlorophenyl)-2′-(2-methoxyphenyl)-2′,4,5,6,6′,6a-hexahydro-3aH,4′H-spiro[cyclopenta[d][1,3]dioxole-2,5′-cyclopenta[c]pyrazole];3-(4-chlorophenyl)-5-(2,6-dimethylmorpholin-4-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-(4-methylpiperidin-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-5-(3,3-diethylpyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-5-(3,3-dimethylpyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(5-chlorothiophen-2-yl)-2-(2-methoxyphenyl)-5′,5′-dimethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxane];3-(5-chlorothiophen-2-yl)-2-(2-methoxyphenyl)-4′,4′,5′,5′-tetramethyl-2,6-dihydro-4H-spiro[cyclopenta[c]pyrazole-5,2′-[1,3]dioxolane];3-(4-chlorophenyl)-2-(2-methoxyphenyl)-5-pyrrolidin-1-yl-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;3-(4-chlorophenyl)-5-(3,3-difluoropyrrolidin-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazole;4-[(5S)-5-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;methyl1-[(5S)-3-(4-cyanophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1H-1,2,3-triazole-4-carboxylate;4-[(5S)-5-[4-(1-hydroxy-1-methylethyl)-1H-1,2,3-triazol-1-yl]-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-{(5S)-2-(2-methoxyphenyl)-5-[4-(2-methylpropyl)-1H-1,2,3-triazol-1-yl]-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl}benzonitrile;{1-[(5S)-3-(4-cyanophenyl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-5-yl]-1H-1,2,3-triazol-4-yl}methylacetate;4-[(5S)-5-[4-(methoxymethyl)-1H-1,2,3-triazol-1-yl]-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(4-tert-butyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(4,5-dimethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-2-(2-methoxyphenyl)-5-(2,4,5-trimethyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(2-ethyl-4,5-dimethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(2-ethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-2-(2-methoxyphenyl)-5-(2-methyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(4,5-diethyl-1H-1,2,3-triazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-2-(2-methoxyphenyl)-5-(2,4,5-triethyl-1H-imidazol-1-yl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(4,5-diethyl-2-methyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;4-[(5S)-5-(4,5-diethyl-1H-imidazol-1-yl)-2-(2-methoxyphenyl)-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl]benzonitrile;or a pharmaceutically acceptable salt form thereof.
 15. A pharmaceuticalcomposition comprising a compound of claim 1 or 14 and at least one of apharmaceutically acceptable carrier, a pharmaceutically acceptableexcipient, and a pharmaceutically acceptable diluent.
 16. Thepharmaceutical composition of claim 15, wherein the composition is asolid oral dosage form.
 17. The pharmaceutical composition of claim 15,wherein the composition is a syrup, an elixir or a suspension.
 18. Amethod for treating inflammatory pain in a subject in need thereofcomprising administering to the subject a therapeutically effectiveamount of a compound of claim 1 or
 14. 19. The method of claim 18wherein the inflammatory pain is due to inflammatory bowel disease,irritable bowel syndrome, visceral pain, migraine, post-operative pain,osteoarthritis, rheumatoid arthritis, back pain, lower back pain, jointpain, abdominal pain, chest pain, labor pain, musculoskeletal diseases,skin diseases, toothache, pyresis, burn, sunburn, snake bite, venomoussnake bite, spider bite, insect sting, neurogenic/overactive bladder,interstitial cystitis, urinary tract infection, rhinitis, contactdermatitis/hypersensitivity, itch, eczema, pharyngitis, mucositis,enteritis, irritable bowel syndrome, cholecystitis, pancreatitis,postmastectomy pain syndrome, menstrual pain, endometriosis, pain, paindue to physical trauma, headache, sinus headache, tension headache orarachnoiditis.
 20. A method for treating neuropathic pain in a subjectin need thereof comprising administering to the subject atherapeutically effective amount of a compound of claim 1 or
 14. 21. Themethod of claim 20, wherein the neuropathic pain is caused by cancerpain, neurological disorders, spine and peripheral nerve surgery, braintumor, traumatic brain injury (TBI), chemotherapy-induced pain, painchronification, radicular pain, HIV pain, spinal cord trauma, chronicpain syndrome, fibromyalgia, chronic fatigue syndrome, lupus,sarcoidosis, peripheral neuropathy, bilateral peripheral neuropathy,diabetic neuropathy, central pain, neuropathies associated with spinalcord injury, stroke, amyotrophic lateral sclerosis (ALS), Parkinson'sdisease, multiple sclerosis, sciatic neuritis, mandibular jointneuralgia, peripheral neuritis, polyneuritis, stump pain, phantom limbpain, bony fractures, oral neuropathic pain, Charcot's pain, complexregional pain syndrome I and II (CRPS I/II), radiculopathy,Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome,optic neuritis, postfebrile neuritis, migrating neuritis, segmentalneuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia,cranial neuralgia, geniculate neuralgia, glossopharyngial neuralgia,migrainous neuralgia, idiopathic neuralgia, intercostals neuralgia,mammary neuralgia, Morton's neuralgia, nasociliary neuralgia, occipitalneuralgia, postherpetic neuralgia, causalgia, red neuralgia, Sluder'sneuralgia, splenopalatine neuralgia, supraorbital neuralgia, trigeminalneuralgia, vulvodynia, or vidian neuralgia.